CRCGN011_HEPG2_24H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

165 genes differentially expressed following the CRCGN011_HEPG2_24H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
STIMATE STIM activating enhancer 9.24555
CSK c-src tyrosine kinase 5.81625
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.1726
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.01635
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.9031
TLR4 toll-like receptor 4 4.88665
CIAO3 cytosolic iron-sulfur assembly component 3 4.83625
RPP38 ribonuclease P/MRP 38kDa subunit 4.83115
MAMLD1 mastermind-like domain containing 1 4.71615
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.64315
CCNF cyclin F 4.29897
STAP2 signal transducing adaptor family member 2 4.0059
NMU neuromedin U 4.0059
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.92086
MAP7 microtubule-associated protein 7 3.50023
EPHB2 EPH receptor B2 3.36562
PLSCR1 phospholipid scramblase 1 3.28393
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 3.21605
LCN2 lipocalin 2 3.0069
OASL 2'-5'-oligoadenylate synthetase-like 2.93257
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.91405
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.90202
CASP5 caspase 5, apoptosis-related cysteine peptidase 2.88605
SLC75A1 solute carrier family 75 member 1 2.8303
GPATCH8 G patch domain containing 8 2.79478
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.78805
EVL Enah/Vasp-like 2.7839
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.7821
TIAM1 T-cell lymphoma invasion and metastasis 1 2.71505
RTP4 receptor (chemosensory) transporter protein 4 2.7091
PDYN prodynorphin 2.6744
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.6331
APLNR apelin receptor 2.6058
PLSCR3 phospholipid scramblase 3 2.59485
MX2 MX dynamin-like GTPase 2 2.5669
RSAD2 radical S-adenosyl methionine domain containing 2 2.5645
NENF neudesin neurotrophic factor 2.5623
GMPR guanosine monophosphate reductase 2.5573
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.55465
IFI44 interferon-induced protein 44 2.5319
FASTKD5 FAST kinase domains 5 2.52375
BIRC2 baculoviral IAP repeat containing 2 2.4954
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.4612
ARID4B AT rich interactive domain 4B (RBP1-like) 2.4529
NANOS2 nanos homolog 2 (Drosophila) 2.45
IFI44L interferon-induced protein 44-like 2.44985
ATF7IP2 activating transcription factor 7 interacting protein 2 2.4432
SPON1 spondin 1, extracellular matrix protein 2.43165
TPSG1 tryptase gamma 1 2.4187
GJC2 gap junction protein, gamma 2, 47kDa 2.41275
GATA2 GATA binding protein 2 2.40175
RIGI RNA sensor RIG-I 2.4008
FAM3A family with sequence similarity 3, member A 2.38203
DUOX2 dual oxidase 2 2.38105
GARRE1 granule associated Rac and RHOG effector 1 2.3714
CDX1 caudal type homeobox 1 2.3584
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.3496
RBMX2 RNA binding motif protein, X-linked 2 2.34675
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.33135
PCSK7 proprotein convertase subtilisin/kexin type 7 2.32675
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.32
CEP57 centrosomal protein 57kDa 2.31139
RASL10A RAS-like, family 10, member A 2.2768
TPSD1 tryptase delta 1 2.2708
SOX17 SRY (sex determining region Y)-box 17 2.2696
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.26155
NPPA natriuretic peptide A 2.25675
RAD54L RAD54-like (S. cerevisiae) 2.2493
TRIM25 tripartite motif containing 25 2.24375
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.22575
WNT11 wingless-type MMTV integration site family, member 11 2.2193
S100A5 S100 calcium binding protein A5 2.215
INPPL1 inositol polyphosphate phosphatase-like 1 2.21245
E4F1 E4F transcription factor 1 2.21145
CCNT1 cyclin T1 2.2076
NECAB2 N-terminal EF-hand calcium binding protein 2 2.1877
HSPA1L heat shock 70kDa protein 1-like 2.18365
HLA-DRA major histocompatibility complex, class II, DR alpha 2.18318
GTPBP2 GTP binding protein 2 2.17725
DLEC1 deleted in lung and esophageal cancer 1 2.16105
RHOT2 ras homolog family member T2 2.15582
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.14315
AQP1 aquaporin 1 (Colton blood group) 2.14302
RPGR retinitis pigmentosa GTPase regulator 2.1395
MIIP migration and invasion inhibitory protein 2.1228
CAPN5 calpain 5 2.1201
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.10967
NEK11 NIMA-related kinase 11 2.10755
MTM1 myotubularin 1 2.10687
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.10675
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.105
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.0989
ZNF562 zinc finger protein 562 2.09805
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2.09675
IL25 interleukin 25 2.0789
RBM22 RNA binding motif protein 22 2.07745
MX1 MX dynamin-like GTPase 1 2.0757
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.0695
CHAD chondroadherin 2.0625
TSNAX translin-associated factor X 2.0618
NAAA N-acylethanolamine acid amidase 2.05925
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 2.04398
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.04335
MORN1 MORN repeat containing 1 2.04265
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.0364
ECEL1 endothelin converting enzyme-like 1 2.02775
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.0258
OLIG2 oligodendrocyte lineage transcription factor 2 2.025
EXTL1 exostosin-like glycosyltransferase 1 2.01285
TMSB4Y thymosin beta 4, Y-linked 2.01205
IFI35 interferon-induced protein 35 2.0115
IFI6 interferon, alpha-inducible protein 6 2.0077
CCR2 chemokine (C-C motif) receptor 2 2.00563
DACH1 dachshund family transcription factor 1 2.0012

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -6.37747
NT5DC2 5'-nucleotidase domain containing 2 -5.55955
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.5392
MRPS2 mitochondrial ribosomal protein S2 -5.27115
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.12365
TRIB3 tribbles pseudokinase 3 -5.0
LDHD lactate dehydrogenase D -4.97195
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86965
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.83665
PCNA proliferating cell nuclear antigen -4.7455
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.73615
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.5463
TLCD3A TLC domain containing 3A -4.3958
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.29117
VAT1 vesicle amine transport 1 -4.2698
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.20025
ITGB1BP1 integrin beta 1 binding protein 1 -4.12703
TMEM147 transmembrane protein 147 -3.96085
PEG10 paternally expressed 10 -3.9188
CCNB2 cyclin B2 -3.5576
TBCB tubulin folding cofactor B -3.30078
SESN1 sestrin 1 -3.1232
OXA1L oxidase (cytochrome c) assembly 1-like -2.8474
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.78305
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.73322
SCAND1 SCAN domain containing 1 -2.5527
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.4824
HLA-DMA major histocompatibility complex, class II, DM alpha -2.479
SGCE sarcoglycan, epsilon -2.45555
TPCN1 two pore segment channel 1 -2.3389
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.25315
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.2475
GOLGA8F golgin A8 family, member F -2.2261
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.1951
REEP5 receptor accessory protein 5 -2.19105
S100A14 S100 calcium binding protein A14 -2.18765
PSENEN presenilin enhancer gamma secretase subunit -2.18515
PLK2 polo-like kinase 2 -2.18395
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.1794
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.12295
CRISP3 cysteine-rich secretory protein 3 -2.07965
RETN resistin -2.0764
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.0718
LGALSL lectin, galactoside-binding-like -2.0675
RAB38 RAB38, member RAS oncogene family -2.058
CYB5A cytochrome b5 type A (microsomal) -2.04882
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.04185
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.02055
CAPNS1 calpain, small subunit 1 -2.01835
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.00505