CRCGN011_HEPG2_24H:B14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 20.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN011_HEPG2_24H:B14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 9.3097
TIAM1 T-cell lymphoma invasion and metastasis 1 6.85927
STIMATE STIM activating enhancer 5.342
RBM15B RNA binding motif protein 15B 5.18905
NOTCH1 notch 1 4.89815
MYLK myosin light chain kinase 4.83585
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.54895
VAV3 vav 3 guanine nucleotide exchange factor 3.88955
HEATR1 HEAT repeat containing 1 3.67292
TLR4 toll-like receptor 4 3.1836
JADE2 jade family PHD finger 2 2.6789
PIH1D1 PIH1 domain containing 1 2.5613
CHEK2 checkpoint kinase 2 2.41755
ANAPC1 anaphase promoting complex subunit 1 2.3841
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.3404
DENND2D DENN/MADD domain containing 2D 2.33965
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.26065
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.2235
EPHA3 EPH receptor A3 2.1673
ADGRE5 adhesion G protein-coupled receptor E5 2.14205
DTYMK deoxythymidylate kinase (thymidylate kinase) 2.12035
TNS2 tensin 2 2.1016
PCDHB11 protocadherin beta 11 2.07076
AAMP angio-associated, migratory cell protein 2.03695
MREG melanoregulin 2.015
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.00095
CHN1 chimerin 1 2.00025

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCDC86 coiled-coil domain containing 86 -5.6474
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -5.31665
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.1585
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.744
NT5DC2 5'-nucleotidase domain containing 2 -4.66275
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.43875
ADI1 acireductone dioxygenase 1 -3.71345
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.6628
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.066
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.82297
ITGB1BP1 integrin beta 1 binding protein 1 -2.55748
OXA1L oxidase (cytochrome c) assembly 1-like -2.547
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.50905
NGRN neugrin, neurite outgrowth associated -2.32005
ITGB7 integrin, beta 7 -2.31795
CIDEA cell death-inducing DFFA-like effector a -2.313
SDCBP syndecan binding protein (syntenin) -2.2476
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -2.1831
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.15775
RGS9BP regulator of G protein signaling 9 binding protein -2.1509
RNF167 ring finger protein 167 -2.10885
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.09845
ZNF586 zinc finger protein 586 -2.08045
KRT9 keratin 9, type I -2.07645
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 -2.0751
BPHL biphenyl hydrolase-like (serine hydrolase) -2.03625
DUSP8 dual specificity phosphatase 8 -2.0324
GDF15 growth differentiation factor 15 -2.0105
TKFC triokinase/FMN cyclase -2.00985