CRCGN011_HEPG2_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 5.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN011_HEPG2_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MINDY1 MINDY lysine 48 deubiquitinase 1 10.0
CYCS cytochrome c, somatic 5.5864
CXCL2 chemokine (C-X-C motif) ligand 2 5.33065
PRR15L proline rich 15-like 5.3264
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.0546
LCN2 lipocalin 2 5.0
STIMATE STIM activating enhancer 4.7489
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7112
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.55745
MAP7 microtubule-associated protein 7 3.77557
TIAM1 T-cell lymphoma invasion and metastasis 1 3.31148
WDTC1 WD and tetratricopeptide repeats 1 3.19568
DENND2D DENN/MADD domain containing 2D 3.12085
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.78665
FOXJ3 forkhead box J3 2.67945
ADAT1 adenosine deaminase, tRNA-specific 1 2.6583
JADE2 jade family PHD finger 2 2.60563
PRKCH protein kinase C, eta 2.50582
CALU calumenin 2.30903
ATP5PD ATP synthase peripheral stalk subunit d 2.2903
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.2873
RPL18 ribosomal protein L18 2.26095
TEAD3 TEA domain family member 3 2.16085
DEFA4 defensin, alpha 4, corticostatin 2.1332
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.12245
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.0985
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.08243
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B 2.081
RPL36A ribosomal protein L36a 2.0773
TBCA tubulin folding cofactor A 2.0697
SORBS3 sorbin and SH3 domain containing 3 2.04553
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.03995
CCR8 chemokine (C-C motif) receptor 8 2.02195
CCNF cyclin F 2.01605

decreased expression

Symbol Name Standardized Value
USP6NL USP6 N-terminal like -6.0598
CDC20 cell division cycle 20 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8422
LAP3 leucine aminopeptidase 3 -4.7232
EIF5 eukaryotic translation initiation factor 5 -4.24625
TWF2 twinfilin actin binding protein 2 -3.86525
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.81105
CCNB2 cyclin B2 -3.01745
TMEM187 transmembrane protein 187 -2.8407
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.83275
PRPF4 pre-mRNA processing factor 4 -2.8327
FOS FBJ murine osteosarcoma viral oncogene homolog -2.5491
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.37325
RFC2 replication factor C (activator 1) 2, 40kDa -2.25277
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.20505
LIAS lipoic acid synthetase -2.16855
SETMAR SET domain and mariner transposase fusion gene -2.1201
CCNH cyclin H -2.0312
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.00535
STAP2 signal transducing adaptor family member 2 -2.0027