| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | phenylephrine 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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60 genes differentially expressed following the CRCGN011_HEPG2_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BZW2 | basic leucine zipper and W2 domains 2 | 5.2873 |
| MYLK | myosin light chain kinase | 5.2458 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 5.0795 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.07005 |
| NOTCH1 | notch 1 | 4.96155 |
| CHEK2 | checkpoint kinase 2 | 4.93355 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.90175 |
| CSK | c-src tyrosine kinase | 4.66275 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 4.43945 |
| GATA3 | GATA binding protein 3 | 3.82937 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.80045 |
| BIRC2 | baculoviral IAP repeat containing 2 | 3.24425 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.0513 |
| SLC75A1 | solute carrier family 75 member 1 | 3.01135 |
| TEX10 | testis expressed 10 | 2.8316 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.8253 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 2.59635 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.40595 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.3864 |
| PHF2 | PHD finger protein 2 | 2.37385 |
| STC1 | stanniocalcin 1 | 2.2805 |
| SMAD3 | SMAD family member 3 | 2.26544 |
| PLTP | phospholipid transfer protein | 2.2551 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 2.11165 |
| MSMB | microseminoprotein, beta- | 2.11123 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 2.09665 |
| GPN3 | GPN-loop GTPase 3 | 2.03955 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2.03105 |
| EPHA3 | EPH receptor A3 | 2.01862 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 2.018 |
| TRH | thyrotropin-releasing hormone | 2.0156 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | 2.01345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -5.0284 |
| ENOPH1 | enolase-phosphatase 1 | -4.78045 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.71785 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.34715 |
| CD320 | CD320 molecule | -4.26575 |
| HMG20B | high mobility group 20B | -4.18192 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -4.00853 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.94965 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.93605 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -3.37308 |
| LYPLA1 | lysophospholipase I | -3.3649 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -3.33762 |
| PCNA | proliferating cell nuclear antigen | -3.2651 |
| GNAS | GNAS complex locus | -3.15718 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -3.00135 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.9592 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -2.83323 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.6643 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.61285 |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | -2.3884 |
| POU2AF1 | POU class 2 associating factor 1 | -2.3631 |
| HOPX | HOP homeobox | -2.2945 |
| MZB1 | marginal zone B and B1 cell-specific protein | -2.2222 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.13998 |
| CCL3L3 | chemokine (C-C motif) ligand 3-like 3 | -2.1152 |
| MAT2B | methionine adenosyltransferase II, beta | -2.07045 |
| GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | -2.03 |
| DCK | deoxycytidine kinase | -2.01465 |
