CRCGN011_HEPG2_24H:B18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN011_HEPG2_24H:B18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 4.91515
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.76805
MAMLD1 mastermind-like domain containing 1 4.7344
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.49164
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.974
BIRC2 baculoviral IAP repeat containing 2 3.8421
TLR4 toll-like receptor 4 3.61245
PRR15L proline rich 15-like 3.6074
ABHD6 abhydrolase domain containing 6 3.6043
GATA3 GATA binding protein 3 3.08405
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.96415
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.8508
GPATCH8 G patch domain containing 8 2.68092
BAD BCL2-associated agonist of cell death 2.6561
ADAT1 adenosine deaminase, tRNA-specific 1 2.65135
TIAM1 T-cell lymphoma invasion and metastasis 1 2.61028
GPER1 G protein-coupled estrogen receptor 1 2.59627
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.55875
ST20-MTHFS ST20-MTHFS readthrough 2.5177
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.50295
LBHD1 LBH domain containing 1 2.4283
PLSCR3 phospholipid scramblase 3 2.42343
CFI complement factor I 2.383
HOOK2 hook microtubule-tethering protein 2 2.34255
BMP4 bone morphogenetic protein 4 2.27575
CCNF cyclin F 2.21778
IFI6 interferon, alpha-inducible protein 6 2.20385
KAT2A K(lysine) acetyltransferase 2A 2.20145
ZNF443 zinc finger protein 443 2.15595
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.12943
ZNF783 zinc finger family member 783 2.10658
CYCS cytochrome c, somatic 2.097
TCTN2 tectonic family member 2 2.0837
IGFBP6 insulin-like growth factor binding protein 6 2.06745
PTH2R parathyroid hormone 2 receptor 2.0513
CREB5 cAMP responsive element binding protein 5 2.02085
MUS81 MUS81 structure-specific endonuclease subunit 2.01205

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.221
TRIB3 tribbles pseudokinase 3 -5.38535
ADI1 acireductone dioxygenase 1 -4.9496
MRPS2 mitochondrial ribosomal protein S2 -4.87075
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.7565
MAP7 microtubule-associated protein 7 -4.62203
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.5478
COG7 component of oligomeric golgi complex 7 -4.29895
CDC20 cell division cycle 20 -4.2155
PEG10 paternally expressed 10 -4.17982
FGFR4 fibroblast growth factor receptor 4 -3.9437
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.26674
GNAS GNAS complex locus -3.23889
CCNB2 cyclin B2 -3.22895
WASHC4 WASH complex subunit 4 -3.14785
SLC35F2 solute carrier family 35, member F2 -3.0436
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.7931
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.72385
MPO myeloperoxidase -2.5796
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.54375
CCDC28A coiled-coil domain containing 28A -2.49705
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.46305
H1-10 H1.10 linker histone -2.43465
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.33135
VPREB1 pre-B lymphocyte 1 -2.24765
DNAI1 dynein, axonemal, intermediate chain 1 -2.22995
PPP4C protein phosphatase 4, catalytic subunit -2.224
TSC1 tuberous sclerosis 1 -2.17905
SPEF1 sperm flagellar 1 -2.17875
UBAC1 UBA domain containing 1 -2.161
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.1416
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.14015
ZMYND10 zinc finger, MYND-type containing 10 -2.12678
PIERCE1 piercer of microtubule wall 1 -2.12068
CFAP45 cilia and flagella associated protein 45 -2.1006
SESN1 sestrin 1 -2.0998
ZDHHC11B zinc finger, DHHC-type containing 11B -2.0984
RAB36 RAB36, member RAS oncogene family -2.09055
MYLIP myosin regulatory light chain interacting protein -2.0892
GPR27 G protein-coupled receptor 27 -2.0823
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.0822
TBXT T-box transcription factor T -2.06845
CFAP44 cilia and flagella associated protein 44 -2.0575
SH3GL1 SH3-domain GRB2-like 1 -2.056
PHF7 PHD finger protein 7 -2.04885
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.04505
ZBBX zinc finger, B-box domain containing -2.02365
ZSCAN5A zinc finger and SCAN domain containing 5A -2.0226
RAB30 RAB30, member RAS oncogene family -2.01975
IFT88 intraflagellar transport 88 -2.01015
TENM3 teneurin transmembrane protein 3 -2.00465
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.00415