CRCGN011_HEPG2_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description gemfibrozil 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN011_HEPG2_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SYNE2 spectrin repeat containing, nuclear envelope 2 5.4899
CSK c-src tyrosine kinase 5.08485
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.85555
PPARG peroxisome proliferator-activated receptor gamma 4.8277
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.5705
PIH1D1 PIH1 domain containing 1 3.56865
LOC122526780 uncharacterized LOC122526780 3.27625
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.20595
HLA-DRA major histocompatibility complex, class II, DR alpha 2.97403
COL11A1 collagen, type XI, alpha 1 2.61258
KIF5C kinesin family member 5C 2.60845
WDTC1 WD and tetratricopeptide repeats 1 2.59727
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.5758
TRIM13 tripartite motif containing 13 2.5527
ABHD4 abhydrolase domain containing 4 2.5016
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.4484
PTK2 protein tyrosine kinase 2 2.33905
CHN1 chimerin 1 2.32245
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.14685
RNF11 ring finger protein 11 2.0849
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.07645
MCM9 minichromosome maintenance complex component 9 2.067
NUP133 nucleoporin 133kDa 2.05185
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.04775
TRIP12 thyroid hormone receptor interactor 12 2.0052

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.2083
TLCD3A TLC domain containing 3A -6.57885
TRIB3 tribbles pseudokinase 3 -5.431
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.1382
PCNA proliferating cell nuclear antigen -5.0
TWF2 twinfilin actin binding protein 2 -4.6616
ZNF586 zinc finger protein 586 -4.6331
KDM3A lysine (K)-specific demethylase 3A -4.5283
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.37285
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.3183
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.7092
VDAC1 voltage-dependent anion channel 1 -3.63745
GNAS GNAS complex locus -3.52461
MAPK13 mitogen-activated protein kinase 13 -3.2824
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.25253
CSNK1E casein kinase 1, epsilon -2.62657
HMG20B high mobility group 20B -2.58975
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.54945
SNX11 sorting nexin 11 -2.5431
GRN granulin -2.44135
LIMA1 LIM domain and actin binding 1 -2.4099
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.3619
ITGB1BP1 integrin beta 1 binding protein 1 -2.3122
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.25971
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.25925
CNTFR ciliary neurotrophic factor receptor -2.2105
RRAS related RAS viral (r-ras) oncogene homolog -2.1976
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -2.18875
MARCO macrophage receptor with collagenous structure -2.1469
DERA deoxyribose-phosphate aldolase (putative) -2.1431
TYR tyrosinase -2.1271
TMEM74B transmembrane protein 74B -2.12095
CCL27 chemokine (C-C motif) ligand 27 -2.08525
YEATS2 YEATS domain containing 2 -2.02045