CRCGN011_HEPG2_24H:B21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description gemfibrozil 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

133 genes differentially expressed following the CRCGN011_HEPG2_24H:B21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 6.51175
STIMATE STIM activating enhancer 5.88955
GPATCH8 G patch domain containing 8 5.04728
SNAP25 synaptosomal-associated protein, 25kDa 4.90042
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.89945
STAP2 signal transducing adaptor family member 2 4.86485
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.64035
CHMP6 charged multivesicular body protein 6 4.521
SMIM40 small integral membrane protein 40 4.1906
NSDHL NAD(P) dependent steroid dehydrogenase-like 4.1613
PEX11A peroxisomal biogenesis factor 11 alpha 3.99937
TIAM1 T-cell lymphoma invasion and metastasis 1 3.66542
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.589
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.54718
MAP7 microtubule-associated protein 7 3.4278
PRKCH protein kinase C, eta 3.3369
GPER1 G protein-coupled estrogen receptor 1 3.2286
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.21435
SPRED2 sprouty-related, EVH1 domain containing 2 3.18068
CDC45 cell division cycle 45 3.0627
ZNF274 zinc finger protein 274 3.0224
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.92515
HYOU1 hypoxia up-regulated 1 2.9241
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.91235
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.86302
GRHL2 grainyhead-like 2 (Drosophila) 2.83765
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.713
EXD3 exonuclease 3'-5' domain containing 3 2.63665
DCTD dCMP deaminase 2.58057
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.5579
KRT13 keratin 13, type I 2.5572
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.52625
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 2.5052
FOXJ2 forkhead box J2 2.4713
PMM2 phosphomannomutase 2 2.46055
SSBP2 single-stranded DNA binding protein 2 2.45858
LDAF1 lipid droplet assembly factor 1 2.45245
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.3755
MAGEA6 melanoma antigen family A6 2.3686
PLXNA2 plexin A2 2.36515
KRT24 keratin 24, type I 2.3569
GRTP1 growth hormone regulated TBC protein 1 2.35545
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 2.34387
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.3279
LOC100652777 group 10 secretory phospholipase A2-like 2.30805
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.30615
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.29675
MUC4 mucin 4, cell surface associated 2.28875
ARMC7 armadillo repeat containing 7 2.28825
RNLS renalase, FAD-dependent amine oxidase 2.25565
ATF7IP2 activating transcription factor 7 interacting protein 2 2.25385
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.2513
RAD54L RAD54-like (S. cerevisiae) 2.2464
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.2358
RARS1 arginyl-tRNA synthetase 1 2.2309
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.2153
H2BC15 H2B clustered histone 15 2.2105
GNL1 guanine nucleotide binding protein-like 1 2.20795
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.20495
COG4 component of oligomeric golgi complex 4 2.19785
CD40 CD40 molecule, TNF receptor superfamily member 5 2.1802
CLCA4 chloride channel accessory 4 2.17825
ZNF324B zinc finger protein 324B 2.17245
MAOB monoamine oxidase B 2.16945
DGCR6L DiGeorge syndrome critical region gene 6-like 2.16365
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.16085
ACVR2A activin A receptor, type IIA 2.15965
NKX3-2 NK3 homeobox 2 2.1574
DUOX2 dual oxidase 2 2.1478
RBM15B RNA binding motif protein 15B 2.14365
ALS2CL ALS2 C-terminal like 2.14085
TNIP1 TNFAIP3 interacting protein 1 2.13245
SPRR3 small proline-rich protein 3 2.1298
CDH22 cadherin 22, type 2 2.12375
S100A14 S100 calcium binding protein A14 2.1183
ERN2 endoplasmic reticulum to nucleus signaling 2 2.11635
GPR32 G protein-coupled receptor 32 2.11195
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.099
FAT2 FAT atypical cadherin 2 2.09195
PEAK1 pseudopodium-enriched atypical kinase 1 2.0834
ELAC2 elaC ribonuclease Z 2 2.07765
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.0759
THAP4 THAP domain containing 4 2.0741
RIBC2 RIB43A domain with coiled-coils 2 2.0714
SPACA9 sperm acrosome associated 9 2.06725
IFT22 intraflagellar transport 22 2.05625
PCDHB11 protocadherin beta 11 2.03906
KNOP1 lysine-rich nucleolar protein 1 2.0389
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.0376
IHH indian hedgehog 2.03665
SH3D19 SH3 domain containing 19 2.02478
NUBP2 nucleotide binding protein 2 2.0193
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.0107
CRYM crystallin, mu 2.01
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.00675
PTK2 protein tyrosine kinase 2 2.00198
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.0011
EMC3 ER membrane protein complex subunit 3 2.0009
PTPRF protein tyrosine phosphatase, receptor type, F 2.0008

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.2372
GOLT1B golgi transport 1B -6.33145
PGAM4 phosphoglycerate mutase family member 4 -5.70195
CD320 CD320 molecule -4.9665
MAPK13 mitogen-activated protein kinase 13 -4.08135
PEG10 paternally expressed 10 -3.97578
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.6536
AURKB aurora kinase B -3.55305
TOMM34 translocase of outer mitochondrial membrane 34 -3.46525
KHDC4 KH domain containing 4, pre-mRNA splicing factor -3.0896
CCNB2 cyclin B2 -2.93655
PROS1 protein S (alpha) -2.89275
TCTN1 tectonic family member 1 -2.7221
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.7073
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.497
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.46575
RNF167 ring finger protein 167 -2.4288
CHMP2B charged multivesicular body protein 2B -2.39483
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.2919
IFT20 intraflagellar transport 20 -2.22475
MBIP MAP3K12 binding inhibitory protein 1 -2.19875
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.19165
ADCY7 adenylate cyclase 7 -2.1661
CTSD cathepsin D -2.1562
ZNF586 zinc finger protein 586 -2.1366
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.1099
SIRT2 sirtuin 2 -2.1054
MT1H metallothionein 1H -2.05885
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.0384
MT1E metallothionein 1E -2.03495
ZNHIT2 zinc finger, HIT-type containing 2 -2.0225
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.0193
DVL2 dishevelled segment polarity protein 2 -2.01157