CRCGN011_HEPG2_24H:B23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description gemfibrozil 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

174 genes differentially expressed following the CRCGN011_HEPG2_24H:B23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
ADRB2 adrenoceptor beta 2, surface 6.07725
CBR3 carbonyl reductase 3 5.709
PLS1 plastin 1 5.62235
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.48585
TLR4 toll-like receptor 4 5.19125
PPARG peroxisome proliferator-activated receptor gamma 5.03425
CXCL2 chemokine (C-X-C motif) ligand 2 5.0281
CIAO3 cytosolic iron-sulfur assembly component 3 5.02085
PEX11A peroxisomal biogenesis factor 11 alpha 5.0009
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8084
MELK maternal embryonic leucine zipper kinase 4.5047
CCL2 chemokine (C-C motif) ligand 2 4.37775
TAC4 tachykinin 4 (hemokinin) 4.3512
SKIC2 SKI2 subunit of superkiller complex 4.27385
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.22475
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.9937
E2F2 E2F transcription factor 2 3.8733
EPN2 epsin 2 3.62305
CYCS cytochrome c, somatic 3.59435
SSBP2 single-stranded DNA binding protein 2 3.51305
JADE2 jade family PHD finger 2 3.40068
KLHL9 kelch-like family member 9 3.26728
KIF5C kinesin family member 5C 3.18375
JUN jun proto-oncogene 3.06117
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 3.0034
GALE UDP-galactose-4-epimerase 2.9783
TYW2 tRNA wybutosine-synthesizing protein 2 2.947
EIF6 eukaryotic translation initiation factor 6 2.93475
TCL1B T-cell leukemia/lymphoma 1B 2.85125
ZNF589 zinc finger protein 589 2.8469
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.83155
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.75588
CHRM3 cholinergic receptor, muscarinic 3 2.74945
GPATCH8 G patch domain containing 8 2.74405
SDC4 syndecan 4 2.735
CREB1 cAMP responsive element binding protein 1 2.7223
RNF14 ring finger protein 14 2.70878
ACBD4 acyl-CoA binding domain containing 4 2.6923
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.67455
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.6614
UBL5 ubiquitin-like 5 2.6604
MAPK7 mitogen-activated protein kinase 7 2.65828
ZNF184 zinc finger protein 184 2.6103
MRNIP MRN complex interacting protein 2.5743
IRF2 interferon regulatory factor 2 2.52595
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.49055
MTCL1 microtubule crosslinking factor 1 2.48685
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.46715
N4BP2L1 NEDD4 binding protein 2-like 1 2.45917
ZNF7 zinc finger protein 7 2.40175
RUNDC3B RUN domain containing 3B 2.38225
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.37815
GPER1 G protein-coupled estrogen receptor 1 2.35655
COQ8A coenzyme Q8A 2.3504
SNX7 sorting nexin 7 2.34155
CAPN10 calpain 10 2.3213
TRPC1 transient receptor potential cation channel, subfamily C, member 1 2.31155
UBXN2B UBX domain protein 2B 2.27155
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.25615
NBPF19 neuroblastoma breakpoint family, member 19 2.2411
CHN1 chimerin 1 2.2395
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.2394
RAD54L RAD54-like (S. cerevisiae) 2.2353
TCN2 transcobalamin II 2.22915
GPATCH1 G patch domain containing 1 2.2281
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 2.2263
MRM2 mitochondrial rRNA methyltransferase 2 2.2161
UIMC1 ubiquitin interaction motif containing 1 2.21185
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.2082
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.20708
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.19872
GOLGA6L9 golgin A6 family-like 9 2.19695
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.19285
ZNF426 zinc finger protein 426 2.18905
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.1868
ZSCAN32 zinc finger and SCAN domain containing 32 2.18517
RWDD3 RWD domain containing 3 2.17945
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.1645
PRDM13 PR domain containing 13 2.1601
ZSCAN16 zinc finger and SCAN domain containing 16 2.14235
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.13245
PCCA propionyl CoA carboxylase, alpha polypeptide 2.1271
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.1245
METTL13 methyltransferase like 13 2.12195
MANSC1 MANSC domain containing 1 2.0958
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.0894
SPAG16 sperm associated antigen 16 2.08705
DPPA4 developmental pluripotency associated 4 2.08325
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.0653
ZNF180 zinc finger protein 180 2.06255
LARS1 leucyl-tRNA synthetase 1 2.0611
PRDM14 PR domain containing 14 2.0547
CAPRIN2 caprin family member 2 2.0491
MAST2 microtubule associated serine/threonine kinase 2 2.04823
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.04685
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.04445
SAXO6 stabilizer of axonemal microtubules 6 2.0422
ACE2 angiotensin I converting enzyme 2 2.03915
SLC25A46 solute carrier family 25, member 46 2.0348
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.03332
ALPL alkaline phosphatase, liver/bone/kidney 2.0327
FLRT3 fibronectin leucine rich transmembrane protein 3 2.0318
METTL4 methyltransferase like 4 2.0275
RNF25 ring finger protein 25 2.02245
CYB561 cytochrome b561 2.0086

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -8.96745
TLCD3A TLC domain containing 3A -7.8803
CCDC86 coiled-coil domain containing 86 -6.0697
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.8086
ERBB2 erb-b2 receptor tyrosine kinase 2 -5.79583
CCNB1 cyclin B1 -5.56915
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.55285
PLK1 polo-like kinase 1 -5.5373
UGDH UDP-glucose 6-dehydrogenase -5.4105
PCCB propionyl CoA carboxylase, beta polypeptide -5.15355
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.12745
CDC20 cell division cycle 20 -5.0
LDHD lactate dehydrogenase D -4.8694
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.7939
YME1L1 YME1-like 1 ATPase -4.6335
KDM3A lysine (K)-specific demethylase 3A -4.45875
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.0418
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.02133
CTNND1 catenin (cadherin-associated protein), delta 1 -3.79072
PSRC1 proline/serine-rich coiled-coil 1 -3.6903
OXA1L oxidase (cytochrome c) assembly 1-like -3.53615
GNAS GNAS complex locus -3.38801
DERA deoxyribose-phosphate aldolase (putative) -3.38665
ARID5B AT rich interactive domain 5B (MRF1-like) -3.32825
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.1791
NRIP1 nuclear receptor interacting protein 1 -3.13662
CCNB2 cyclin B2 -3.0669
PCNA proliferating cell nuclear antigen -3.0425
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.0313
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.8131
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.69365
LOXL1 lysyl oxidase-like 1 -2.68855
ARCN1 archain 1 -2.6784
SH2B3 SH2B adaptor protein 3 -2.65025
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.5473
MTPAP mitochondrial poly(A) polymerase -2.51025
HSPA14 heat shock 70kDa protein 14 -2.5101
ACAA1 acetyl-CoA acyltransferase 1 -2.4863
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.4858
RDX radixin -2.48457
LYPLA1 lysophospholipase I -2.42112
PIMREG PICALM interacting mitotic regulator -2.3944
ATP5F1C ATP synthase F1 subunit gamma -2.37153
CDC123 cell division cycle 123 -2.35435
MMP7 matrix metallopeptidase 7 -2.3512
FCGBP Fc fragment of IgG binding protein -2.33125
OLFML2A olfactomedin-like 2A -2.32885
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.32265
DEAF1 DEAF1 transcription factor -2.2785
SCAMP4 secretory carrier membrane protein 4 -2.23205
PDCD6IP programmed cell death 6 interacting protein -2.2301
CREB3L2 cAMP responsive element binding protein 3-like 2 -2.2181
NPDC1 neural proliferation, differentiation and control, 1 -2.20775
UBE4A ubiquitination factor E4A -2.2071
RGCC regulator of cell cycle -2.19415
WDR37 WD repeat domain 37 -2.1877
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.15005
LIMA1 LIM domain and actin binding 1 -2.1394
PBK PDZ binding kinase -2.1367
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.13457
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) -2.1056
SLC16A6 solute carrier family 16, member 6 -2.0987
CDC25B cell division cycle 25B -2.0906
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.06875
JAK1 Janus kinase 1 -2.0205
PEX13 peroxisomal biogenesis factor 13 -2.01835
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -2.00485
PYCARD PYD and CARD domain containing -2.0016