CRCGN011_HEPG2_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethoxane 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

105 genes differentially expressed following the CRCGN011_HEPG2_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.0299
BACE2 beta-site APP-cleaving enzyme 2 4.8349
TBPL1 TBP-like 1 4.0172
SSBP2 single-stranded DNA binding protein 2 3.76135
CYCS cytochrome c, somatic 3.58375
TIAM1 T-cell lymphoma invasion and metastasis 1 3.51108
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.48992
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.3085
PEX2 peroxisomal biogenesis factor 2 2.8434
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.8019
PFKL phosphofructokinase, liver 2.77678
FASTKD5 FAST kinase domains 5 2.7608
PGK1 phosphoglycerate kinase 1 2.62833
USP21 ubiquitin specific peptidase 21 2.45415
SREK1 splicing regulatory glutamine/lysine-rich protein 1 2.38365
RUVBL1 RuvB-like AAA ATPase 1 2.3503
ENOPH1 enolase-phosphatase 1 2.2637
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.19095
NUP54 nucleoporin 54kDa 2.15085
CRYZ crystallin, zeta (quinone reductase) 2.11325
CEMIP2 cell migration inducing hyaluronidase 2 2.099
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.07975
MDN1 MDN1, midasin homolog (yeast) 2.07925
SPC25 SPC25, NDC80 kinetochore complex component 2.0755
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.0742
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.0642
ERCC6L excision repair cross-complementation group 6-like 2.03955
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02095

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.3529
GNAS GNAS complex locus -7.27934
PCCB propionyl CoA carboxylase, beta polypeptide -5.3174
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0854
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.4533
CDC20 cell division cycle 20 -4.2155
ZMIZ1 zinc finger, MIZ-type containing 1 -3.9549
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.9413
GRWD1 glutamate-rich WD repeat containing 1 -3.88555
WASHC4 WASH complex subunit 4 -3.30173
PCNA proliferating cell nuclear antigen -3.29635
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.26123
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.119
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 -3.04915
ZPBP zona pellucida binding protein -2.98535
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.9765
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.93615
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 -2.8432
ACRV1 acrosomal vesicle protein 1 -2.69616
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.65135
SQLE squalene epoxidase -2.6438
TSSK2 testis-specific serine kinase 2 -2.5499
TSBP1 testis expressed basic protein 1 -2.54085
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.5304
MAB21L4 mab-21 like 4 -2.51595
SMCP sperm mitochondria-associated cysteine-rich protein -2.4607
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.45163
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.437
LYZL6 lysozyme-like 6 -2.38275
ANKRD7 ankyrin repeat domain 7 -2.37915
DNAAF8 dynein axonemal assembly factor 8 -2.3593
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.35475
TSSK1B testis-specific serine kinase 1B -2.33355
GRK4 G protein-coupled receptor kinase 4 -2.33315
CDC34 cell division cycle 34 -2.3145
NRIP1 nuclear receptor interacting protein 1 -2.3129
TCP11 t-complex 11, testis-specific -2.31165
SHCBP1L SHC SH2-domain binding protein 1-like -2.3034
PRND prion protein 2 (dublet) -2.2994
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -2.2901
ACTL7A actin-like 7A -2.2765
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.26187
PRAMEF13 PRAME family member 13 -2.25985
ADAM29 ADAM metallopeptidase domain 29 -2.25895
UBQLN3 ubiquilin 3 -2.2343
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -2.2267
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 -2.22585
TULP2 tubby like protein 2 -2.2116
CTSB cathepsin B -2.20755
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 -2.20662
ACTL7B actin-like 7B -2.1876
STON1-GTF2A1L STON1-GTF2A1L readthrough -2.171
FTCD formimidoyltransferase cyclodeaminase -2.1475
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.1304
PGM5 phosphoglucomutase 5 -2.1208
PRM2 protamine 2 -2.11545
HOXD11 homeobox D11 -2.1152
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.1026
ODF1 outer dense fiber of sperm tails 1 -2.0997
TMPRSS6 transmembrane protease, serine 6 -2.09675
MCF2 MCF.2 cell line derived transforming sequence -2.08355
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.0811
ADAM20 ADAM metallopeptidase domain 20 -2.0774
ACVR1 activin A receptor, type I -2.0766
AKR1D1 aldo-keto reductase family 1, member D1 -2.0631
PGK2 phosphoglycerate kinase 2 -2.06235
NR0B1 nuclear receptor subfamily 0, group B, member 1 -2.0603
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -2.05305
RBMXL2 RNA binding motif protein, X-linked-like 2 -2.0517
LDHAL6B lactate dehydrogenase A-like 6B -2.0394
PYCR3 pyrroline-5-carboxylate reductase 3 -2.0309
CD79B CD79b molecule, immunoglobulin-associated beta -2.02485
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.01743
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.01725
PXDNL peroxidasin-like -2.01025
HOOK1 hook microtubule-tethering protein 1 -2.0017
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -2.00065