CRCGN011_HEPG2_24H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethoxane 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN011_HEPG2_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.74165
AMDHD2 amidohydrolase domain containing 2 5.18875
MINDY1 MINDY lysine 48 deubiquitinase 1 5.1618
SQOR sulfide quinone oxidoreductase 5.06705
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.99442
CAPN1 calpain 1, (mu/I) large subunit 4.7645
NMU neuromedin U 4.4281
MAP7 microtubule-associated protein 7 4.12668
CXCL2 chemokine (C-X-C motif) ligand 2 4.0713
PEX11A peroxisomal biogenesis factor 11 alpha 4.0451
GHR growth hormone receptor 3.72875
CCL2 chemokine (C-C motif) ligand 2 3.57795
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.5105
CNPY3 canopy FGF signaling regulator 3 3.1981
SSBP2 single-stranded DNA binding protein 2 3.18057
CDC45 cell division cycle 45 3.1551
CYB561 cytochrome b561 3.1501
FASTKD5 FAST kinase domains 5 3.0569
EPHB2 EPH receptor B2 2.9778
HSPA1A heat shock 70kDa protein 1A 2.87885
GARRE1 granule associated Rac and RHOG effector 1 2.58045
RIBC2 RIB43A domain with coiled-coils 2 2.534
SSX1 synovial sarcoma, X breakpoint 1 2.5275
INSL6 insulin-like 6 2.4188
ALOX15 arachidonate 15-lipoxygenase 2.39155
PTTG1 pituitary tumor-transforming 1 2.376
H2AP H2A.P histone 2.37065
CCNO cyclin O 2.36895
EPHA3 EPH receptor A3 2.28528
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.25675
SOX1 SRY (sex determining region Y)-box 1 2.25405
AIG1 androgen-induced 1 2.2257
DIPK1A divergent protein kinase domain 1A 2.21305
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.20475
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.1989
ATP11B ATPase, class VI, type 11B 2.1853
DNAI4 dynein axonemal intermediate chain 4 2.1517
TEF thyrotrophic embryonic factor 2.1295
ADGB androglobin 2.1231
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.1099
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.09955
CENPU centromere protein U 2.09395
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.08235
DMTF1 cyclin D binding myb-like transcription factor 1 2.08137
ADRA1B adrenoceptor alpha 1B 2.0753
ZNF589 zinc finger protein 589 2.07387
PARP2 poly (ADP-ribose) polymerase 2 2.07018
AANAT aralkylamine N-acetyltransferase 2.05125
KIF3A kinesin family member 3A 2.03545
NME5 NME/NM23 family member 5 2.0334
ANKRD37 ankyrin repeat domain 37 2.0202
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.01425
PITPNM3 PITPNM family member 3 2.0131
NEUROG2 neurogenin 2 2.01105
PLAAT3 phospholipase A and acyltransferase 3 2.0094

decreased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -5.52035
USP6NL USP6 N-terminal like -4.8923
ADI1 acireductone dioxygenase 1 -4.84615
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.834
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.7484
CCNB2 cyclin B2 -4.45005
LDHD lactate dehydrogenase D -4.3922
EIF5 eukaryotic translation initiation factor 5 -3.83504
TCEAL4 transcription elongation factor A (SII)-like 4 -3.22595
FHL2 four and a half LIM domains 2 -3.1809
SESN1 sestrin 1 -3.091
ITGB1BP1 integrin beta 1 binding protein 1 -3.07492
IFRD2 interferon-related developmental regulator 2 -2.7022
NRBP1 nuclear receptor binding protein 1 -2.67675
C5 complement component 5 -2.6162
HLA-DMA major histocompatibility complex, class II, DM alpha -2.5483
RFC2 replication factor C (activator 1) 2, 40kDa -2.47407
GRN granulin -2.4443
UBE3C ubiquitin protein ligase E3C -2.4429
WDR43 WD repeat domain 43 -2.3084
RIC8A RIC8 guanine nucleotide exchange factor A -2.1414
MOK MOK protein kinase -2.1153
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.1133
CD58 CD58 molecule -2.09958
FBXO7 F-box protein 7 -2.07695
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.0683
ACOD1 aconitate decarboxylase 1 -2.0616
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.0585
BZW2 basic leucine zipper and W2 domains 2 -2.0576
CDC42SE1 CDC42 small effector 1 -2.0175
TLCD3A TLC domain containing 3A -2.0122
E2F6 E2F transcription factor 6 -2.0108