CRCGN011_HEPG2_24H:C07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

124 genes differentially expressed following the CRCGN011_HEPG2_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 8.70335
LCN2 lipocalin 2 7.732
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.40025
CIAO3 cytosolic iron-sulfur assembly component 3 5.29245
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.95325
CSK c-src tyrosine kinase 4.91515
ABHD4 abhydrolase domain containing 4 4.61085
E2F2 E2F transcription factor 2 4.5396
MYLK myosin light chain kinase 4.38025
SNAP25 synaptosomal-associated protein, 25kDa 4.37875
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.33936
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.27485
WDTC1 WD and tetratricopeptide repeats 1 3.96935
GPER1 G protein-coupled estrogen receptor 1 3.67545
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.51445
CHN1 chimerin 1 3.47105
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.31648
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.169
JADE2 jade family PHD finger 2 2.9884
RIC8A RIC8 guanine nucleotide exchange factor A 2.9782
TBX21 T-box 21 2.9284
TCEA2 transcription elongation factor A (SII), 2 2.83315
ACAD10 acyl-CoA dehydrogenase family, member 10 2.77655
S1PR4 sphingosine-1-phosphate receptor 4 2.6968
SIRT3 sirtuin 3 2.6351
ETHE1 ethylmalonic encephalopathy 1 2.63065
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.61205
HLA-DRA major histocompatibility complex, class II, DR alpha 2.52203
DIPK1A divergent protein kinase domain 1A 2.4484
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.4257
UGP2 UDP-glucose pyrophosphorylase 2 2.3896
RIDA reactive intermediate imine deaminase A homolog 2.38725
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.35027
SOCS2 suppressor of cytokine signaling 2 2.34742
EMC2 ER membrane protein complex subunit 2 2.34485
SDK2 sidekick cell adhesion molecule 2 2.33
CCL17 chemokine (C-C motif) ligand 17 2.2985
EIF1B eukaryotic translation initiation factor 1B 2.2525
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.2441
PRX periaxin 2.23735
YPEL5 yippee-like 5 (Drosophila) 2.2121
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.1957
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.18305
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 2.17993
CYCS cytochrome c, somatic 2.17115
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.16355
GATA2 GATA binding protein 2 2.15373
BIRC2 baculoviral IAP repeat containing 2 2.15125
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.13975
BORCS8 BLOC-1 related complex subunit 8 2.1379
E2F4 E2F transcription factor 4, p107/p130-binding 2.12808
GPATCH8 G patch domain containing 8 2.1277
ZNF747 zinc finger protein 747 2.11965
LAX1 lymphocyte transmembrane adaptor 1 2.09195
SFXN1 sideroflexin 1 2.0914
HTRA2 HtrA serine peptidase 2 2.08737
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.08705
PSG5 pregnancy specific beta-1-glycoprotein 5 2.07955
RGCC regulator of cell cycle 2.07735
CCL1 chemokine (C-C motif) ligand 1 2.07605
TREML2 triggering receptor expressed on myeloid cells-like 2 2.076
ZBTB32 zinc finger and BTB domain containing 32 2.04265
TERF2 telomeric repeat binding factor 2 2.028
HMOX1 heme oxygenase 1 2.0204
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A 2.01525
LRRC8D leucine rich repeat containing 8 family, member D 2.01505
PSG2 pregnancy specific beta-1-glycoprotein 2 2.01305
REEP2 receptor accessory protein 2 2.0083
CRIPT cysteine-rich PDZ-binding protein 2.00815
TCAP titin-cap 2.0066
OXLD1 oxidoreductase-like domain containing 1 2.0034

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -7.71465
RPN1 ribophorin I -5.5583
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.3981
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.20545
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.0249
DNM1L dynamin 1-like -5.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.92615
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.92515
KDM3A lysine (K)-specific demethylase 3A -4.7958
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.699
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.6413
CHMP4B charged multivesicular body protein 4B -4.4083
ADI1 acireductone dioxygenase 1 -4.3944
MAPK13 mitogen-activated protein kinase 13 -4.28085
MAP7 microtubule-associated protein 7 -4.14703
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.878
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.84046
ZNF274 zinc finger protein 274 -3.8338
COPG1 coatomer protein complex, subunit gamma 1 -3.79465
YME1L1 YME1-like 1 ATPase -3.7896
GNAS GNAS complex locus -3.7323
LOC124907782 dual specificity protein phosphatase 22 -3.4629
CTNND1 catenin (cadherin-associated protein), delta 1 -3.41053
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.39228
GDF15 growth differentiation factor 15 -3.1895
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.17602
SLC35F2 solute carrier family 35, member F2 -3.0816
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.9874
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.9346
NGRN neugrin, neurite outgrowth associated -2.8429
HEATR1 HEAT repeat containing 1 -2.7247
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.64895
SAE1 SUMO1 activating enzyme subunit 1 -2.5858
BAG4 BCL2-associated athanogene 4 -2.4905
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.43892
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.38095
FAM50A family with sequence similarity 50, member A -2.29655
CCNJ cyclin J -2.29075
SNRPG small nuclear ribonucleoprotein polypeptide G -2.27735
COL9A3 collagen, type IX, alpha 3 -2.2336
CAVIN1 caveolae associated protein 1 -2.22092
POGK pogo transposable element with KRAB domain -2.21205
XPO4 exportin 4 -2.2066
SOCS6 suppressor of cytokine signaling 6 -2.20622
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.20103
CCL23 chemokine (C-C motif) ligand 23 -2.1369
RTN3 reticulon 3 -2.13645
NUTF2 nuclear transport factor 2 -2.13565
MEX3D mex-3 RNA binding family member D -2.06615
HOXA5 homeobox A5 -2.0457
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.04565
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02332
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.0097