CRCGN011_HEPG2_24H:C09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN011_HEPG2_24H:C09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.73125
STIMATE STIM activating enhancer 5.57515
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.4818
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8466
CDPF1 cysteine-rich, DPF motif domain containing 1 4.52695
EPHB2 EPH receptor B2 4.47595
ABHD6 abhydrolase domain containing 6 4.22207
CYCS cytochrome c, somatic 4.13595
CHN1 chimerin 1 3.11565
RAB31 RAB31, member RAS oncogene family 2.60813
ZNF589 zinc finger protein 589 2.5107
HOOK2 hook microtubule-tethering protein 2 2.25055
NVL nuclear VCP-like 2.18425
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.033
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.0241
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.0179
MRPL4 mitochondrial ribosomal protein L4 2.01295

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.8122
GNAS GNAS complex locus -7.151
ZW10 zw10 kinetochore protein -5.32795
PCNA proliferating cell nuclear antigen -4.7455
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.62725
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.50635
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.7885
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.68287
OXA1L oxidase (cytochrome c) assembly 1-like -2.6801
HEATR1 HEAT repeat containing 1 -2.50995
ITPKC inositol-trisphosphate 3-kinase C -2.42035
CRIP2 cysteine-rich protein 2 -2.3816
EIF5 eukaryotic translation initiation factor 5 -2.33581
FAT1 FAT atypical cadherin 1 -2.16055
PCBP3 poly(rC) binding protein 3 -2.06345
BTK Bruton agammaglobulinemia tyrosine kinase -2.01535