CRCGN011_HEPG2_24H:C10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN011_HEPG2_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5.59625
E2F2 E2F transcription factor 2 5.33725
CXCL2 chemokine (C-X-C motif) ligand 2 5.3145
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.216
CIAO3 cytosolic iron-sulfur assembly component 3 5.2156
CCDC85B coiled-coil domain containing 85B 4.6473
PPARG peroxisome proliferator-activated receptor gamma 4.51885
CHMP6 charged multivesicular body protein 6 4.51085
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.47085
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.36975
MAP7 microtubule-associated protein 7 3.76797
SSBP2 single-stranded DNA binding protein 2 3.45857
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.36925
PRKCH protein kinase C, eta 3.31918
LOC122526780 uncharacterized LOC122526780 3.1985
MAST2 microtubule associated serine/threonine kinase 2 3.16227
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.11225
ARPP19 cAMP-regulated phosphoprotein, 19kDa 3.10057
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.10005
FGF6 fibroblast growth factor 6 2.673
DIPK1A divergent protein kinase domain 1A 2.55597
MEST mesoderm specific transcript 2.52585
HRAS Harvey rat sarcoma viral oncogene homolog 2.50355
HLA-DRA major histocompatibility complex, class II, DR alpha 2.48387
ARID5B AT rich interactive domain 5B (MRF1-like) 2.42925
CKS2 CDC28 protein kinase regulatory subunit 2 2.4015
LCN2 lipocalin 2 2.39915
P3H3 prolyl 3-hydroxylase 3 2.3891
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 2.36295
PRKCG protein kinase C, gamma 2.3398
ATP11B ATPase, class VI, type 11B 2.3112
MRPL30 mitochondrial ribosomal protein L30 2.2916
SPEF1 sperm flagellar 1 2.29135
UBXN6 UBX domain protein 6 2.24305
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.2216
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.21415
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.2095
EXOSC5 exosome component 5 2.19405
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.19185
RAB40C RAB40C, member RAS oncogene family 2.1402
RASL10A RAS-like, family 10, member A 2.1372
CHN1 chimerin 1 2.13595
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.09915
DNAL4 dynein, axonemal, light chain 4 2.08985
POLR1B polymerase (RNA) I polypeptide B, 128kDa 2.05415
MTERF3 mitochondrial transcription termination factor 3 2.04905
HMGB3 high mobility group box 3 2.0434
ADGRG1 adhesion G protein-coupled receptor G1 2.03743
DNAH6 dynein, axonemal, heavy chain 6 2.03465
SCT secretin 2.0276
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.02285
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 2.0207
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.01885
WDTC1 WD and tetratricopeptide repeats 1 2.01282

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
GNAS GNAS complex locus -7.32289
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.3675
TRIB3 tribbles pseudokinase 3 -5.22595
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.17295
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.90965
NT5DC2 5'-nucleotidase domain containing 2 -4.90605
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.73905
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.56655
ANKRD10 ankyrin repeat domain 10 -4.353
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.6116
NRIP1 nuclear receptor interacting protein 1 -3.32382
TLCD3A TLC domain containing 3A -2.9754
CHIC2 cysteine-rich hydrophobic domain 2 -2.85275
IPO13 importin 13 -2.806
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.768
GDF15 growth differentiation factor 15 -2.7538
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.5547
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.5337
LARP7 La ribonucleoprotein domain family, member 7 -2.5136
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.4318
ARHGAP15 Rho GTPase activating protein 15 -2.3818
PRAME preferentially expressed antigen in melanoma -2.28575
SPAG4 sperm associated antigen 4 -2.22885
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.20195
CADM1 cell adhesion molecule 1 -2.18212
SNX10 sorting nexin 10 -2.1821
RALYL RALY RNA binding protein-like -2.17245
RBM34 RNA binding motif protein 34 -2.17228
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1653
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.12655
KRABD4 KRAB domain containing 4 -2.0927
LHX2 LIM homeobox 2 -2.0554
SV2B synaptic vesicle glycoprotein 2B -2.03835
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.0371
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.0256
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.02489
PRPF8 pre-mRNA processing factor 8 -2.02415
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.02295
SEPTIN6 septin 6 -2.01694