CRCGN011_HEPG2_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

51 genes differentially expressed following the CRCGN011_HEPG2_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.77935
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.59315
CXCL2 chemokine (C-X-C motif) ligand 2 5.05845
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.0528
MYLK myosin light chain kinase 4.92965
LYN LYN proto-oncogene, Src family tyrosine kinase 4.0821
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.00311
CYCS cytochrome c, somatic 3.54015
ATP11B ATPase, class VI, type 11B 3.46505
TAC4 tachykinin 4 (hemokinin) 3.38095
CHN1 chimerin 1 3.11365
TRIM13 tripartite motif containing 13 3.1026
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.9234
MEST mesoderm specific transcript 2.8757
JADE2 jade family PHD finger 2 2.63447
DNM1 dynamin 1 2.5325
CAPN1 calpain 1, (mu/I) large subunit 2.51945
GLRB glycine receptor, beta 2.2985
DHDDS dehydrodolichyl diphosphate synthase 2.27227
CISD1 CDGSH iron sulfur domain 1 2.25355
IFI6 interferon, alpha-inducible protein 6 2.19575
SFTPB surfactant protein B 2.1421
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.12437
MCM3 minichromosome maintenance complex component 3 2.1242
EPHA3 EPH receptor A3 2.10457
OSBPL10 oxysterol binding protein-like 10 2.0829
PXMP2 peroxisomal membrane protein 2, 22kDa 2.0715
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.02172
SMIM40 small integral membrane protein 40 2.0198
VEGFB vascular endothelial growth factor B 2.01645
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.01335

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.4544
LDHD lactate dehydrogenase D -5.04365
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.68595
GRWD1 glutamate-rich WD repeat containing 1 -3.32905
VDAC1 voltage-dependent anion channel 1 -3.27455
CAB39 calcium binding protein 39 -3.21655
CDC25B cell division cycle 25B -3.01545
C5 complement component 5 -2.6344
REEP5 receptor accessory protein 5 -2.62503
OXA1L oxidase (cytochrome c) assembly 1-like -2.29945
ZNF586 zinc finger protein 586 -2.28965
NLRP4 NLR family, pyrin domain containing 4 -2.2873
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1489
TNIP1 TNFAIP3 interacting protein 1 -2.1356
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.1088
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.0686
HADH hydroxyacyl-CoA dehydrogenase -2.06678
INTS12 integrator complex subunit 12 -2.0467
ECI2 enoyl-CoA delta isomerase 2 -2.03375
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.0333