CRCGN011_HEPG2_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description maleic hydrazide 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN011_HEPG2_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.00495
UBQLN2 ubiquilin 2 4.94375
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.93185
CBR3 carbonyl reductase 3 4.88655
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.4659
CARMIL1 capping protein regulator and myosin 1 linker 1 4.1971
PRR15L proline rich 15-like 3.68905
SSBP2 single-stranded DNA binding protein 2 3.529
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.5071
GPER1 G protein-coupled estrogen receptor 1 3.1529
KIF5C kinesin family member 5C 3.05403
MAST2 microtubule associated serine/threonine kinase 2 2.79798
LCN2 lipocalin 2 2.44265
PARP2 poly (ADP-ribose) polymerase 2 2.183
ADGRG1 adhesion G protein-coupled receptor G1 2.1791
TPD52L2 tumor protein D52-like 2 2.16935
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.06775
PLTP phospholipid transfer protein 2.05245
GADD45A growth arrest and DNA-damage-inducible, alpha 2.0518

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -5.73755
RPN1 ribophorin I -5.7057
MAPK13 mitogen-activated protein kinase 13 -5.317
PLK1 polo-like kinase 1 -5.29275
PCNA proliferating cell nuclear antigen -5.04925
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0381
ADI1 acireductone dioxygenase 1 -4.95715
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.42585
FGFR4 fibroblast growth factor receptor 4 -4.26123
EIF5 eukaryotic translation initiation factor 5 -4.15769
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.79395
WASHC4 WASH complex subunit 4 -3.44618
UBE3C ubiquitin protein ligase E3C -2.6891
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.4756
OMG oligodendrocyte myelin glycoprotein -2.42895
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.41132
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.39985
SLC38A12 solute carrier family 38 member 12 -2.3836
GDF15 growth differentiation factor 15 -2.37975
CCNB2 cyclin B2 -2.3675
C5 complement component 5 -2.3481
CDCA3 cell division cycle associated 3 -2.34025
UPK3A uroplakin 3A -2.2409
MATN4 matrilin 4 -2.23825
VDAC1 voltage-dependent anion channel 1 -2.21285
TBX19 T-box 19 -2.20695
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.12535
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.09075
ACAA1 acetyl-CoA acyltransferase 1 -2.085
NT5DC3 5'-nucleotidase domain containing 3 -2.08415
FAIM2 Fas apoptotic inhibitory molecule 2 -2.0742
KDM3B lysine (K)-specific demethylase 3B -2.06947
CYBC1 cytochrome b-245 chaperone 1 -2.0684
MORC4 MORC family CW-type zinc finger 4 -2.0364
IL36RN interleukin 36 receptor antagonist -2.03085
PRPF4 pre-mRNA processing factor 4 -2.02645
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.02375
ELL2 elongation factor, RNA polymerase II, 2 -2.0003