| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | maleic hydrazide 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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259 genes differentially expressed following the CRCGN011_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 5.8924 |
| GSTZ1 | glutathione S-transferase zeta 1 | 5.85365 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.6253 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 5.5609 |
| STIMATE | STIM activating enhancer | 5.53875 |
| NOTCH1 | notch 1 | 5.4488 |
| STK10 | serine/threonine kinase 10 | 5.4389 |
| UBQLN2 | ubiquilin 2 | 5.38055 |
| ADRB2 | adrenoceptor beta 2, surface | 5.32445 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 5.1381 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.1324 |
| E2F2 | E2F transcription factor 2 | 4.97705 |
| CHMP6 | charged multivesicular body protein 6 | 4.8857 |
| LCN2 | lipocalin 2 | 4.8651 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8015 |
| HDGFL3 | HDGF like 3 | 4.72647 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.6746 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 4.4434 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.87295 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.71265 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 3.7085 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.6774 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.6656 |
| RXYLT1 | ribitol xylosyltransferase 1 | 3.55422 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.55065 |
| CSK | c-src tyrosine kinase | 3.52215 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 3.4446 |
| CYCS | cytochrome c, somatic | 3.42555 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 3.42215 |
| CAPN1 | calpain 1, (mu/I) large subunit | 3.40075 |
| KIF5C | kinesin family member 5C | 3.34928 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 3.32485 |
| GATA3 | GATA binding protein 3 | 3.16085 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.1282 |
| PLSCR3 | phospholipid scramblase 3 | 3.09435 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.06967 |
| CCNF | cyclin F | 2.98972 |
| CHN1 | chimerin 1 | 2.98775 |
| SRBD1 | S1 RNA binding domain 1 | 2.9591 |
| PARP1 | poly (ADP-ribose) polymerase 1 | 2.89485 |
| TRAPPC13 | trafficking protein particle complex 13 | 2.8588 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.84795 |
| MEST | mesoderm specific transcript | 2.8222 |
| GALE | UDP-galactose-4-epimerase | 2.7897 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 2.77735 |
| CRCT1 | cysteine-rich C-terminal 1 | 2.74575 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 2.71085 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.7106 |
| PIH1D1 | PIH1 domain containing 1 | 2.7075 |
| NAP1L2 | nucleosome assembly protein 1-like 2 | 2.66655 |
| PYGM | phosphorylase, glycogen, muscle | 2.666 |
| RAB31 | RAB31, member RAS oncogene family | 2.58918 |
| THAP11 | THAP domain containing 11 | 2.52885 |
| IFT70A | intraflagellar transport 70A | 2.4936 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | 2.48465 |
| LRRC42 | leucine rich repeat containing 42 | 2.4805 |
| JADE2 | jade family PHD finger 2 | 2.46555 |
| S100A2 | S100 calcium binding protein A2 | 2.4326 |
| COQ3 | coenzyme Q3 methyltransferase | 2.4301 |
| NME7 | NME/NM23 family member 7 | 2.4199 |
| ZNF415 | zinc finger protein 415 | 2.418 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 2.38985 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | 2.3528 |
| SPOUT1 | SPOUT domain containing methyltransferase 1 | 2.3519 |
| MCM9 | minichromosome maintenance complex component 9 | 2.34145 |
| NECTIN4 | nectin cell adhesion molecule 4 | 2.3307 |
| ABHD4 | abhydrolase domain containing 4 | 2.2961 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.29595 |
| NFE2 | nuclear factor, erythroid 2 | 2.29445 |
| ZNF165 | zinc finger protein 165 | 2.2934 |
| RIPPLY2-CYB5R4 | RIPPLY2-CYB5R4 readthrough | 2.29015 |
| SIRT3 | sirtuin 3 | 2.28813 |
| TTI2 | TELO2 interacting protein 2 | 2.28805 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | 2.2795 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 2.2793 |
| METTL4 | methyltransferase like 4 | 2.27345 |
| DVL2 | dishevelled segment polarity protein 2 | 2.26965 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.24985 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 2.2456 |
| PEX2 | peroxisomal biogenesis factor 2 | 2.2113 |
| IL1A | interleukin 1, alpha | 2.2053 |
| JADE3 | jade family PHD finger 3 | 2.20375 |
| NEK4 | NIMA-related kinase 4 | 2.20365 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | 2.20095 |
| FASTKD5 | FAST kinase domains 5 | 2.19405 |
| MYOT | myotilin | 2.1931 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 2.1916 |
| EHD3 | EH-domain containing 3 | 2.18825 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 2.1874 |
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | 2.1754 |
| LCN1 | lipocalin 1 | 2.17535 |
| P2RX7 | purinergic receptor P2X, ligand gated ion channel, 7 | 2.16705 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 2.16442 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.16285 |
| WDR19 | WD repeat domain 19 | 2.1567 |
| TNFSF12-TNFSF13 | TNFSF12-TNFSF13 readthrough | 2.1546 |
| KRT14 | keratin 14, type I | 2.14275 |
| RAD51B | RAD51 paralog B | 2.13837 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 2.1373 |
| CYB561 | cytochrome b561 | 2.13616 |
| ZBED2 | zinc finger, BED-type containing 2 | 2.1349 |
| S100A8 | S100 calcium binding protein A8 | 2.13315 |
| FIRRM | FIGNL1 interacting regulator of recombination and mitosis | 2.13295 |
| DNM3 | dynamin 3 | 2.13225 |
| INSIG1 | insulin induced gene 1 | 2.12717 |
| ILF2 | interleukin enhancer binding factor 2 | 2.1261 |
| KISS1 | KiSS-1 metastasis-suppressor | 2.11075 |
| TMEM74B | transmembrane protein 74B | 2.10905 |
| ODF2 | outer dense fiber of sperm tails 2 | 2.1081 |
| RAB26 | RAB26, member RAS oncogene family | 2.10545 |
| CDA | cytidine deaminase | 2.09845 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | 2.09625 |
| EDC4 | enhancer of mRNA decapping 4 | 2.09595 |
| ANKRD10 | ankyrin repeat domain 10 | 2.07885 |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 2.07875 |
| CHAD | chondroadherin | 2.07835 |
| KRT5 | keratin 5, type II | 2.0777 |
| FBXO3 | F-box protein 3 | 2.0762 |
| DEPDC5 | DEP domain containing 5 | 2.07565 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | 2.06592 |
| MANEA | mannosidase, endo-alpha | 2.04635 |
| RHOH | ras homolog family member H | 2.04435 |
| MYBBP1A | MYB binding protein (P160) 1a | 2.03925 |
| MED21 | mediator complex subunit 21 | 2.03758 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 2.0362 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 2.02935 |
| PTH2R | parathyroid hormone 2 receptor | 2.0252 |
| NKX2-2 | NK2 homeobox 2 | 2.02345 |
| EDNRA | endothelin receptor type A | 2.02067 |
| GMFB | glia maturation factor, beta | 2.0172 |
| SERF1A | small EDRK-rich factor 1A (telomeric) | 2.005 |
| WRN | Werner syndrome, RecQ helicase-like | 2.00225 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| CCNB2 | cyclin B2 | -7.72995 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.452 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -5.39905 |
| TRIB3 | tribbles pseudokinase 3 | -5.17515 |
| CCDC86 | coiled-coil domain containing 86 | -5.07525 |
| GDF15 | growth differentiation factor 15 | -4.93405 |
| ADI1 | acireductone dioxygenase 1 | -4.8661 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -4.86325 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.8488 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.8415 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -4.7828 |
| PCNA | proliferating cell nuclear antigen | -4.7455 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -4.7045 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.66275 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -4.6324 |
| DERA | deoxyribose-phosphate aldolase (putative) | -4.5747 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -4.52805 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -4.52773 |
| RGS2 | regulator of G-protein signaling 2 | -4.46475 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.4408 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -4.36005 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -4.28792 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -4.26627 |
| CHMP4B | charged multivesicular body protein 4B | -4.10955 |
| TCTN1 | tectonic family member 1 | -4.0322 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.8549 |
| RPS5 | ribosomal protein S5 | -3.81945 |
| TLCD3A | TLC domain containing 3A | -3.54485 |
| ZW10 | zw10 kinetochore protein | -3.4392 |
| GNAS | GNAS complex locus | -3.36554 |
| FCHO1 | FCH domain only 1 | -3.2688 |
| RPS27 | ribosomal protein S27 | -3.24895 |
| RPLP1 | ribosomal protein, large, P1 | -3.18795 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -3.1304 |
| SYNGR3 | synaptogyrin 3 | -2.9984 |
| ADAM9 | ADAM metallopeptidase domain 9 | -2.9952 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.97077 |
| SLC35F2 | solute carrier family 35, member F2 | -2.87795 |
| RPL4 | ribosomal protein L4 | -2.83132 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.8261 |
| MZT2B | mitotic spindle organizing protein 2B | -2.798 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.77915 |
| RNF167 | ring finger protein 167 | -2.7708 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -2.76255 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.71182 |
| SHPK | sedoheptulokinase | -2.66635 |
| RPL37 | ribosomal protein L37 | -2.62075 |
| LOC107986346 | mitochondrial import receptor subunit TOM7 homolog | -2.58345 |
| EXT1 | exostosin glycosyltransferase 1 | -2.55235 |
| CCNL2 | cyclin L2 | -2.5319 |
| RPL36 | ribosomal protein L36 | -2.5195 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | -2.503 |
| NPIPB5 | nuclear pore complex interacting protein family, member B5 | -2.4934 |
| ZNF512B | zinc finger protein 512B | -2.47685 |
| FLCN | folliculin | -2.4437 |
| RPS12 | ribosomal protein S12 | -2.4209 |
| RPL12 | ribosomal protein L12 | -2.40107 |
| MRPL46 | mitochondrial ribosomal protein L46 | -2.37925 |
| RPL29 | ribosomal protein L29 | -2.35975 |
| RPS8 | ribosomal protein S8 | -2.35645 |
| VDAC1 | voltage-dependent anion channel 1 | -2.3552 |
| RPS13 | ribosomal protein S13 | -2.354 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -2.34335 |
| TBCA | tubulin folding cofactor A | -2.33445 |
| RPL7A | ribosomal protein L7a | -2.31105 |
| TMCC2 | transmembrane and coiled-coil domain family 2 | -2.30945 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | -2.30805 |
| RPL27 | ribosomal protein L27 | -2.3007 |
| WDR12 | WD repeat domain 12 | -2.3003 |
| RPS17 | ribosomal protein S17 | -2.29992 |
| MZT2A | mitotic spindle organizing protein 2A | -2.2959 |
| RPL32 | ribosomal protein L32 | -2.29 |
| RPS7 | ribosomal protein S7 | -2.28282 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.2788 |
| MAP1LC3C | microtubule-associated protein 1 light chain 3 gamma | -2.2701 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -2.2698 |
| ATG4B | autophagy related 4B, cysteine peptidase | -2.24235 |
| BFAR | bifunctional apoptosis regulator | -2.24065 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -2.22565 |
| RPS19 | ribosomal protein S19 | -2.22302 |
| RPS11 | ribosomal protein S11 | -2.22075 |
| BCL7B | B-cell CLL/lymphoma 7B | -2.21975 |
| RPL23A | ribosomal protein L23a | -2.21435 |
| NDUFC1 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | -2.20695 |
| RPS18 | ribosomal protein S18 | -2.20365 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | -2.20252 |
| RPS15 | ribosomal protein S15 | -2.2019 |
| RPL3 | ribosomal protein L3 | -2.18843 |
| ACTG1 | actin gamma 1 | -2.15893 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | -2.1458 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.14365 |
| TENM1 | teneurin transmembrane protein 1 | -2.13695 |
| RPL27A | ribosomal protein L27a | -2.13075 |
| RHEB | Ras homolog enriched in brain | -2.12342 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -2.1226 |
| UBC | ubiquitin C | -2.11993 |
| SALL1 | spalt-like transcription factor 1 | -2.11435 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | -2.11417 |
| EIF2D | eukaryotic translation initiation factor 2D | -2.11095 |
| ROM1 | retinal outer segment membrane protein 1 | -2.10985 |
| E2F6 | E2F transcription factor 6 | -2.10875 |
| RPLP0 | ribosomal protein, large, P0 | -2.10177 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | -2.1004 |
| RPL13A | ribosomal protein L13a | -2.09661 |
| RPS2 | ribosomal protein S2 | -2.09601 |
| SNRPE | small nuclear ribonucleoprotein polypeptide E | -2.0924 |
| RPL41 | ribosomal protein L41 | -2.0924 |
| RPL11 | ribosomal protein L11 | -2.08775 |
| RPL7 | ribosomal protein L7 | -2.07048 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -2.06815 |
| RTF2 | replication termination factor 2 | -2.0676 |
| URGCP | upregulator of cell proliferation | -2.0659 |
| RPS29 | ribosomal protein S29 | -2.06535 |
| CPLX3 | complexin 3 | -2.06395 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | -2.0508 |
| RPL18A | ribosomal protein L18a | -2.0497 |
| KCTD7 | potassium channel tetramerization domain containing 7 | -2.04255 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | -2.0375 |
| RPS16 | ribosomal protein S16 | -2.03555 |
| RPL38 | ribosomal protein L38 | -2.0334 |
| RPS15A | ribosomal protein S15a | -2.02785 |
| CD1C | CD1c molecule | -2.0158 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -2.01435 |
| TPT1 | tumor protein, translationally-controlled 1 | -2.01429 |
| UGT2A3 | UDP glucuronosyltransferase 2 family, polypeptide A3 | -2.00855 |
| CA5A | carbonic anhydrase VA, mitochondrial | -2.00785 |
