| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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287 genes differentially expressed following the CRCGN011_HEPG2_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD4 | abhydrolase domain containing 4 | 6.32835 |
| INPP1 | inositol polyphosphate-1-phosphatase | 5.5341 |
| LCN2 | lipocalin 2 | 5.51025 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 5.4669 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 5.3686 |
| CSK | c-src tyrosine kinase | 5.21075 |
| CAPN1 | calpain 1, (mu/I) large subunit | 4.84105 |
| UBQLN2 | ubiquilin 2 | 4.7418 |
| MSRA | methionine sulfoxide reductase A | 4.6498 |
| RPL39L | ribosomal protein L39-like | 4.6355 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.61945 |
| NANOS3 | nanos homolog 3 (Drosophila) | 4.54255 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.42495 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 4.24129 |
| TXNRD1 | thioredoxin reductase 1 | 4.2088 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 4.04682 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.9871 |
| CDC25B | cell division cycle 25B | 3.98525 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 3.95785 |
| CYCS | cytochrome c, somatic | 3.9572 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.89615 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 3.74065 |
| KIFBP | kinesin family binding protein | 3.73015 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 3.47943 |
| NINL | ninein-like | 3.4626 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 3.4265 |
| RRAGA | Ras-related GTP binding A | 3.2818 |
| GLRX | glutaredoxin (thioltransferase) | 3.27535 |
| GPATCH8 | G patch domain containing 8 | 3.2573 |
| SLC25A46 | solute carrier family 25, member 46 | 3.201 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 3.1728 |
| CRTAP | cartilage associated protein | 3.1484 |
| PTK2 | protein tyrosine kinase 2 | 3.05158 |
| CCP110 | centriolar coiled coil protein 110kDa | 3.00385 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 2.9793 |
| RFWD3 | ring finger and WD repeat domain 3 | 2.95405 |
| F8A2 | coagulation factor VIII-associated 2 | 2.899 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 2.88617 |
| ATP5MC3 | ATP synthase membrane subunit c locus 3 | 2.87733 |
| DHX16 | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 2.86375 |
| IMPDH1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | 2.8543 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | 2.8374 |
| RAP1GAP | RAP1 GTPase activating protein | 2.8023 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.79995 |
| EI24 | etoposide induced 2.4 | 2.79905 |
| VAT1 | vesicle amine transport 1 | 2.7751 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | 2.75882 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.71945 |
| MAFG | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G | 2.7015 |
| ST20-MTHFS | ST20-MTHFS readthrough | 2.6803 |
| FBLN2 | fibulin 2 | 2.67015 |
| TEX10 | testis expressed 10 | 2.6531 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 2.63057 |
| GAA | glucosidase, alpha; acid | 2.6284 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.6245 |
| WFDC2 | WAP four-disulfide core domain 2 | 2.594 |
| SQSTM1 | sequestosome 1 | 2.58558 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | 2.5659 |
| ORC6 | origin recognition complex, subunit 6 | 2.55885 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.55318 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.55188 |
| STIP1 | stress-induced phosphoprotein 1 | 2.53618 |
| NPTN | neuroplastin | 2.4862 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.4743 |
| HPS5 | Hermansky-Pudlak syndrome 5 | 2.46735 |
| PRB4 | proline-rich protein BstNI subfamily 4 | 2.465 |
| CLTA | clathrin, light chain A | 2.4586 |
| HSPA1A | heat shock 70kDa protein 1A | 2.45555 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 2.4515 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 2.44775 |
| NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 2.44655 |
| STMN2 | stathmin 2 | 2.42575 |
| TUBB6 | tubulin, beta 6 class V | 2.4233 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.3995 |
| DSG2 | desmoglein 2 | 2.39075 |
| EMC8 | ER membrane protein complex subunit 8 | 2.3792 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.37235 |
| CBR1 | carbonyl reductase 1 | 2.3707 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 2.36055 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 2.3574 |
| NUP43 | nucleoporin 43kDa | 2.3555 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 2.3552 |
| BCL2L2 | BCL2-like 2 | 2.3154 |
| CH25H | cholesterol 25-hydroxylase | 2.3046 |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 2.29755 |
| AIMP2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | 2.2946 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.28555 |
| RLIM | ring finger protein, LIM domain interacting | 2.28255 |
| SLC9B2 | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 | 2.2773 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 2.2758 |
| BAD | BCL2-associated agonist of cell death | 2.27245 |
| ISCU | iron-sulfur cluster assembly enzyme | 2.2677 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 2.2493 |
| MFAP4 | microfibrillar-associated protein 4 | 2.24485 |
| OGDHL | oxoglutarate dehydrogenase-like | 2.2422 |
| BRCA1 | breast cancer 1, early onset | 2.23703 |
| RABGGTA | Rab geranylgeranyltransferase, alpha subunit | 2.23675 |
| ELAVL4 | ELAV like neuron-specific RNA binding protein 4 | 2.22725 |
| PRB3 | proline-rich protein BstNI subfamily 3 | 2.2207 |
| NNT | nicotinamide nucleotide transhydrogenase | 2.2202 |
| KCTD14 | potassium channel tetramerization domain containing 14 | 2.1993 |
| COX5A | cytochrome c oxidase subunit Va | 2.1966 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 2.19575 |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 | 2.19425 |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 2.17607 |
| CLCNKA | chloride channel, voltage-sensitive Ka | 2.16725 |
| CAPN3 | calpain 3, (p94) | 2.1621 |
| USP6 | ubiquitin specific peptidase 6 | 2.15345 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.14737 |
| LSG1 | large 60S subunit nuclear export GTPase 1 | 2.1461 |
| MVP | major vault protein | 2.1456 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 2.14555 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 2.1454 |
| PRB2 | proline-rich protein BstNI subfamily 2 | 2.14452 |
| RTN4 | reticulon 4 | 2.14167 |
| NCAPH | non-SMC condensin I complex, subunit H | 2.1412 |
| DDX19B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B | 2.1384 |
| FANCI | Fanconi anemia, complementation group I | 2.1299 |
| CD1C | CD1c molecule | 2.12735 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 2.12157 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 2.11155 |
| TJP2 | tight junction protein 2 | 2.10965 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 2.1057 |
| WDR77 | WD repeat domain 77 | 2.10035 |
| ZNF646 | zinc finger protein 646 | 2.09985 |
| TRAM2 | translocation associated membrane protein 2 | 2.09785 |
| BPIFA1 | BPI fold containing family A, member 1 | 2.09455 |
| PPIF | peptidylprolyl isomerase F | 2.086 |
| KIF3C | kinesin family member 3C | 2.06595 |
| GRIP2 | glutamate receptor interacting protein 2 | 2.0649 |
| WASF3 | WAS protein family, member 3 | 2.0643 |
| NLRX1 | NLR family member X1 | 2.0585 |
| CHD9NB | CHD9 neighbor | 2.0577 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 2.05745 |
| NSF | N-ethylmaleimide-sensitive factor | 2.05325 |
| CTSV | cathepsin V | 2.036 |
| NSG2 | neuronal vesicle trafficking associated 2 | 2.0348 |
| OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | 2.03412 |
| AGTPBP1 | ATP/GTP binding protein 1 | 2.0325 |
| NPIPB5 | nuclear pore complex interacting protein family, member B5 | 2.0315 |
| UNC119 | unc-119 homolog (C. elegans) | 2.0266 |
| CST2 | cystatin SA | 2.0257 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 2.02405 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 | 2.0217 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 2.01885 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.00385 |
| METTL17 | methyltransferase like 17 | 2.00305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -6.31485 |
| TRIB3 | tribbles pseudokinase 3 | -6.028 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.65655 |
| LDHD | lactate dehydrogenase D | -5.11295 |
| ZNF274 | zinc finger protein 274 | -5.04835 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.96605 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.86917 |
| HMG20B | high mobility group 20B | -4.59245 |
| MAP7 | microtubule-associated protein 7 | -4.57508 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -4.574 |
| RPIA | ribose 5-phosphate isomerase A | -4.36725 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.25925 |
| GTPBP8 | GTP-binding protein 8 (putative) | -4.1156 |
| MYL9 | myosin, light chain 9, regulatory | -3.9544 |
| CIRBP | cold inducible RNA binding protein | -3.87235 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.76922 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.7578 |
| HDAC2 | histone deacetylase 2 | -3.5201 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -3.44085 |
| LBR | lamin B receptor | -3.43135 |
| KLHDC2 | kelch domain containing 2 | -3.2684 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.22767 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.15655 |
| RGS2 | regulator of G-protein signaling 2 | -3.12645 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -3.02645 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -3.01472 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.98925 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -2.9863 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.8965 |
| C1QA | complement component 1, q subcomponent, A chain | -2.88465 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -2.86545 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.86055 |
| MMRN1 | multimerin 1 | -2.84655 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -2.83635 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -2.72 |
| YME1L1 | YME1-like 1 ATPase | -2.7047 |
| HIRA | histone cell cycle regulator | -2.68745 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -2.6764 |
| ANO3 | anoctamin 3 | -2.6543 |
| NLGN1 | neuroligin 1 | -2.6472 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | -2.64045 |
| PITX2 | paired-like homeodomain 2 | -2.6294 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.6118 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.60602 |
| GID8 | GID complex subunit 8 | -2.6058 |
| KIF14 | kinesin family member 14 | -2.6037 |
| ARB2A | ARB2 cotranscriptional regulator A | -2.55795 |
| CCDC106 | coiled-coil domain containing 106 | -2.5517 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.54425 |
| RAPGEF4 | Rap guanine nucleotide exchange factor (GEF) 4 | -2.5373 |
| P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 | -2.5333 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -2.53092 |
| SREK1IP1 | SREK1-interacting protein 1 | -2.5269 |
| RBM8A | RNA binding motif protein 8A | -2.52224 |
| TYW2 | tRNA wybutosine-synthesizing protein 2 | -2.5221 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | -2.51495 |
| METTL2A | methyltransferase like 2A | -2.48507 |
| C5 | complement component 5 | -2.4743 |
| ANGPT2 | angiopoietin 2 | -2.47047 |
| GATAD2A | GATA zinc finger domain containing 2A | -2.45 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | -2.44412 |
| TLCD3A | TLC domain containing 3A | -2.44265 |
| PEX26 | peroxisomal biogenesis factor 26 | -2.43905 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) | -2.4323 |
| C1QB | complement component 1, q subcomponent, B chain | -2.4221 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.40737 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.39442 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.35955 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -2.34632 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -2.3414 |
| TIPRL | TOR signaling pathway regulator | -2.3372 |
| RAD21 | RAD21 homolog (S. pombe) | -2.3351 |
| ZBTB22 | zinc finger and BTB domain containing 22 | -2.33445 |
| NR1H4 | nuclear receptor subfamily 1, group H, member 4 | -2.3016 |
| NR2E1 | nuclear receptor subfamily 2, group E, member 1 | -2.2946 |
| SMC3 | structural maintenance of chromosomes 3 | -2.28772 |
| ESM1 | endothelial cell-specific molecule 1 | -2.28645 |
| SLC9A3R2 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 | -2.28535 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -2.27422 |
| EHD4 | EH-domain containing 4 | -2.27175 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | -2.26488 |
| ZNF571 | zinc finger protein 571 | -2.2648 |
| CHRM3 | cholinergic receptor, muscarinic 3 | -2.2604 |
| SRI | sorcin | -2.25857 |
| VEGFA | vascular endothelial growth factor A | -2.25691 |
| GRIA3 | glutamate receptor, ionotropic, AMPA 3 | -2.25245 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -2.25 |
| TSPAN12 | tetraspanin 12 | -2.23915 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -2.2319 |
| CDH9 | cadherin 9, type 2 (T1-cadherin) | -2.226 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -2.19745 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -2.19715 |
| NOP53 | NOP53 ribosome biogenesis factor | -2.1934 |
| TENM3 | teneurin transmembrane protein 3 | -2.17515 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.1724 |
| MYOT | myotilin | -2.16755 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.1657 |
| TUFT1 | tuftelin 1 | -2.16065 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -2.15485 |
| TRIM13 | tripartite motif containing 13 | -2.1511 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -2.1492 |
| SKI | SKI proto-oncogene | -2.14535 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -2.13932 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -2.1182 |
| UEVLD | UEV and lactate/malate dehyrogenase domains | -2.11275 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -2.1096 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -2.10605 |
| ZBTB16 | zinc finger and BTB domain containing 16 | -2.10295 |
| PDZRN4 | PDZ domain containing ring finger 4 | -2.1026 |
| CTSD | cathepsin D | -2.0939 |
| NOL11 | nucleolar protein 11 | -2.0911 |
| ZW10 | zw10 kinetochore protein | -2.08875 |
| SLC17A2 | solute carrier family 17, member 2 | -2.08585 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -2.07875 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -2.0787 |
| FPGT | fucose-1-phosphate guanylyltransferase | -2.07845 |
| BCAP29 | B-cell receptor-associated protein 29 | -2.072 |
| MSTN | myostatin | -2.07155 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.06695 |
| ARC | activity-regulated cytoskeleton-associated protein | -2.06625 |
| PRUNE2 | prune homolog 2 (Drosophila) | -2.0662 |
| CD163 | CD163 molecule | -2.06608 |
| TES | testin LIM domain protein | -2.06025 |
| FAT1 | FAT atypical cadherin 1 | -2.06025 |
| CLDN7 | claudin 7 | -2.05845 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -2.0563 |
| RNF139 | ring finger protein 139 | -2.0514 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | -2.039 |
| MYL5 | myosin, light chain 5, regulatory | -2.03545 |
| CD2AP | CD2-associated protein | -2.027 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -2.0246 |
| CYB561 | cytochrome b561 | -2.02396 |
| CCDC47 | coiled-coil domain containing 47 | -2.02065 |
| THAP7 | THAP domain containing 7 | -2.02045 |
| NRCAM | neuronal cell adhesion molecule | -2.01667 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -2.01665 |
| SOAT2 | sterol O-acyltransferase 2 | -2.00977 |
| IFT74 | intraflagellar transport 74 | -2.0094 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -2.0064 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | -2.0057 |
