CRCGN011_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-phenyl-p-phenylenediamine.hcl 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

105 genes differentially expressed following the CRCGN011_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 7.55333
GPER1 G protein-coupled estrogen receptor 1 6.86322
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.54105
TBPL1 TBP-like 1 5.27265
E2F2 E2F transcription factor 2 5.2356
MINDY1 MINDY lysine 48 deubiquitinase 1 5.1161
CCL2 chemokine (C-C motif) ligand 2 4.83195
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.52565
CIAO3 cytosolic iron-sulfur assembly component 3 4.5151
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.47665
STIMATE STIM activating enhancer 4.44515
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.19695
TIAM1 T-cell lymphoma invasion and metastasis 1 4.18937
EPN2 epsin 2 4.15683
CNPY3 canopy FGF signaling regulator 3 4.0271
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.7988
MAP7 microtubule-associated protein 7 3.67575
CYCS cytochrome c, somatic 3.65125
GLRX glutaredoxin (thioltransferase) 3.43183
CDC25B cell division cycle 25B 3.1296
FCHO1 FCH domain only 1 2.99725
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.89415
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.84378
TSKU tsukushi, small leucine rich proteoglycan 2.81095
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.6883
ZFYVE21 zinc finger, FYVE domain containing 21 2.55105
IL4 interleukin 4 2.5192
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.48655
PGR progesterone receptor 2.47555
TMX2 thioredoxin-related transmembrane protein 2 2.46385
TEX10 testis expressed 10 2.45235
NOSIP nitric oxide synthase interacting protein 2.4518
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.45065
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.42595
INPP1 inositol polyphosphate-1-phosphatase 2.39025
GPR22 G protein-coupled receptor 22 2.38155
CIDEB cell death-inducing DFFA-like effector b 2.3182
TPPP3 tubulin polymerization-promoting protein family member 3 2.2911
LMX1B LIM homeobox transcription factor 1, beta 2.2305
NTNG2 netrin G2 2.2187
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.21277
CHN1 chimerin 1 2.1845
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.1744
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.17275
GRM3 glutamate receptor, metabotropic 3 2.1662
VGLL4 vestigial-like family member 4 2.15295
ZNF682 zinc finger protein 682 2.15235
CCP110 centriolar coiled coil protein 110kDa 2.1498
SHH sonic hedgehog 2.1454
CGRRF1 cell growth regulator with ring finger domain 1 2.1014
JPT2 Jupiter microtubule associated homolog 2 2.10103
PLA2G1B phospholipase A2, group IB (pancreas) 2.101
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.09785
RPL39L ribosomal protein L39-like 2.0966
FAM163A family with sequence similarity 163, member A 2.08308
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.0806
SCN11A sodium channel, voltage gated, type XI alpha subunit 2.076
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.06734
SNTG2 syntrophin, gamma 2 2.056
RAB3D RAB3D, member RAS oncogene family 2.05085
FZD8 frizzled class receptor 8 2.0502
LPAR1 lysophosphatidic acid receptor 1 2.03577
PEAK1 pseudopodium-enriched atypical kinase 1 2.01635
GOLGA7 golgin A7 2.01035
GLP2R glucagon-like peptide 2 receptor 2.00585
SPRYD7 SPRY domain containing 7 2.00145
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.00105

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.50615
DHRS7 dehydrogenase/reductase (SDR family) member 7 -7.3945
KDM3A lysine (K)-specific demethylase 3A -6.0146
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.2041
CD320 CD320 molecule -5.0
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.7337
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.01535
CAB39 calcium binding protein 39 -3.66055
TRAP1 TNF receptor-associated protein 1 -3.38935
MYL9 myosin, light chain 9, regulatory -3.3879
RGS2 regulator of G-protein signaling 2 -3.36185
ZMIZ1 zinc finger, MIZ-type containing 1 -3.22995
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.1318
ARID5B AT rich interactive domain 5B (MRF1-like) -2.9388
PCNA proliferating cell nuclear antigen -2.9102
GRWD1 glutamate-rich WD repeat containing 1 -2.8203
SYNGR3 synaptogyrin 3 -2.75715
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.73312
FHL2 four and a half LIM domains 2 -2.7139
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.54995
SPAG4 sperm associated antigen 4 -2.49755
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.48585
BZW2 basic leucine zipper and W2 domains 2 -2.48245
RFC2 replication factor C (activator 1) 2, 40kDa -2.47487
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.46598
CD58 CD58 molecule -2.42828
LBR lamin B receptor -2.39895
TMEM184B transmembrane protein 184B -2.3362
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -2.2984
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.25588
NGRN neugrin, neurite outgrowth associated -2.25005
PIM2 Pim-2 proto-oncogene, serine/threonine kinase -2.1224
TCEAL4 transcription elongation factor A (SII)-like 4 -2.1098
CIRBP cold inducible RNA binding protein -2.09562
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.0843
PRKX protein kinase, X-linked -2.07812
PLVAP plasmalemma vesicle associated protein -2.01405
NLRP4 NLR family, pyrin domain containing 4 -2.0075