| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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104 genes differentially expressed following the CRCGN011_HEPG2_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.2765 |
| TAC4 | tachykinin 4 (hemokinin) | 5.25635 |
| E2F2 | E2F transcription factor 2 | 5.07845 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.89245 |
| UBQLN2 | ubiquilin 2 | 4.84535 |
| MELK | maternal embryonic leucine zipper kinase | 4.75995 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.69575 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.6489 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.5811 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.54515 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 4.4656 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.44865 |
| GRB10 | growth factor receptor-bound protein 10 | 4.04875 |
| COL11A1 | collagen, type XI, alpha 1 | 3.84812 |
| MAP7 | microtubule-associated protein 7 | 3.62863 |
| CCDC92 | coiled-coil domain containing 92 | 3.5688 |
| ABHD4 | abhydrolase domain containing 4 | 3.4739 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.42385 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.37535 |
| TLR4 | toll-like receptor 4 | 3.35335 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.13605 |
| LSR | lipolysis stimulated lipoprotein receptor | 3.02295 |
| FASTKD5 | FAST kinase domains 5 | 2.92525 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.705 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.70428 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.56417 |
| GPATCH8 | G patch domain containing 8 | 2.5543 |
| CHN1 | chimerin 1 | 2.52285 |
| NINJ2 | ninjurin 2 | 2.46565 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | 2.42375 |
| MFAP5 | microfibrillar associated protein 5 | 2.4051 |
| ADRA2A | adrenoceptor alpha 2A | 2.38495 |
| EVL | Enah/Vasp-like | 2.3663 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.32997 |
| DIPK1A | divergent protein kinase domain 1A | 2.30885 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 2.29975 |
| CIDEB | cell death-inducing DFFA-like effector b | 2.2956 |
| XPO6 | exportin 6 | 2.23815 |
| EPYC | epiphycan | 2.1793 |
| LRRC15 | leucine rich repeat containing 15 | 2.1539 |
| EPS8L3 | EPS8-like 3 | 2.1412 |
| TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | 2.1316 |
| EEIG1 | estrogen-induced osteoclastogenesis regulator 1 | 2.12055 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.11705 |
| SCRG1 | stimulator of chondrogenesis 1 | 2.10625 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 2.0803 |
| SNX2 | sorting nexin 2 | 2.0767 |
| GLRX | glutaredoxin (thioltransferase) | 2.07538 |
| MAPK6 | mitogen-activated protein kinase 6 | 2.0677 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.06545 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 2.0595 |
| MEMO1 | mediator of cell motility 1 | 2.0064 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -5.85805 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -5.45255 |
| VAT1 | vesicle amine transport 1 | -4.9126 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.7598 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.3357 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.82715 |
| GNAS | GNAS complex locus | -3.69796 |
| RGS2 | regulator of G-protein signaling 2 | -3.5728 |
| CCNB2 | cyclin B2 | -3.4485 |
| TOR1A | torsin family 1, member A (torsin A) | -3.35427 |
| LBR | lamin B receptor | -3.16915 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -3.16515 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -3.14105 |
| NGRN | neugrin, neurite outgrowth associated | -3.07745 |
| MYL9 | myosin, light chain 9, regulatory | -3.0312 |
| PRPF4 | pre-mRNA processing factor 4 | -2.9441 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.77128 |
| ZW10 | zw10 kinetochore protein | -2.67025 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.63495 |
| GDF15 | growth differentiation factor 15 | -2.6081 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.5534 |
| S100A2 | S100 calcium binding protein A2 | -2.49625 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | -2.48605 |
| EXT1 | exostosin glycosyltransferase 1 | -2.48018 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.41195 |
| USP6NL | USP6 N-terminal like | -2.36465 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -2.35406 |
| DNM2 | dynamin 2 | -2.3472 |
| TRMT2A | tRNA methyltransferase 2 homolog A (S. cerevisiae) | -2.32275 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.32023 |
| KIF14 | kinesin family member 14 | -2.2804 |
| IFT46 | intraflagellar transport 46 | -2.2523 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.23675 |
| JADE3 | jade family PHD finger 3 | -2.2236 |
| BDNF | brain-derived neurotrophic factor | -2.1893 |
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | -2.1826 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -2.1793 |
| LMAN1L | lectin, mannose-binding, 1 like | -2.14625 |
| OXR1 | oxidation resistance 1 | -2.1187 |
| CAB39 | calcium binding protein 39 | -2.114 |
| RFPL2 | ret finger protein-like 2 | -2.08455 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.06315 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -2.04515 |
| PCDHGA3 | protocadherin gamma subfamily A, 3 | -2.04125 |
| PPT2 | palmitoyl-protein thioesterase 2 | -2.02475 |
| CENPE | centromere protein E, 312kDa | -2.01855 |
| KIF18A | kinesin family member 18A | -2.0082 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.00527 |
| ATG7 | autophagy related 7 | -2.0051 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.0047 |
| UBTD1 | ubiquitin domain containing 1 | -2.00235 |
