| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-phenyl-p-phenylenediamine.hcl 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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97 genes differentially expressed following the CRCGN011_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 7.8052 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 6.68305 |
| CBR3 | carbonyl reductase 3 | 5.6861 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.4445 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.0548 |
| MYLK | myosin light chain kinase | 4.68305 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.66275 |
| CHMP6 | charged multivesicular body protein 6 | 4.63635 |
| MOK | MOK protein kinase | 4.5474 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 4.2424 |
| NOSIP | nitric oxide synthase interacting protein | 4.10775 |
| UBQLN2 | ubiquilin 2 | 4.0295 |
| SATB1 | SATB homeobox 1 | 3.72215 |
| CHN1 | chimerin 1 | 3.6925 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.6651 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 3.42033 |
| BIRC2 | baculoviral IAP repeat containing 2 | 3.112 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 3.03074 |
| ATP11B | ATPase, class VI, type 11B | 3.02805 |
| DENND2D | DENN/MADD domain containing 2D | 2.8244 |
| FASTKD5 | FAST kinase domains 5 | 2.82085 |
| LY86 | lymphocyte antigen 86 | 2.7416 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.67638 |
| EVI2B | ecotropic viral integration site 2B | 2.63985 |
| TAC4 | tachykinin 4 (hemokinin) | 2.6255 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.53275 |
| VRK1 | vaccinia related kinase 1 | 2.48265 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 2.47855 |
| NCF4 | neutrophil cytosolic factor 4, 40kDa | 2.47248 |
| CD37 | CD37 molecule | 2.4616 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.4315 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.4204 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 2.3579 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.3385 |
| MX2 | MX dynamin-like GTPase 2 | 2.2996 |
| ICOS | inducible T-cell co-stimulator | 2.2865 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.25137 |
| EVI2A | ecotropic viral integration site 2A | 2.2416 |
| JADE2 | jade family PHD finger 2 | 2.22445 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 2.2158 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 2.17445 |
| DIPK1A | divergent protein kinase domain 1A | 2.15295 |
| MRPL48 | mitochondrial ribosomal protein L48 | 2.1525 |
| ILKAP | integrin-linked kinase-associated serine/threonine phosphatase | 2.12045 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.1165 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.1098 |
| LTC4S | leukotriene C4 synthase | 2.108 |
| EMP3 | epithelial membrane protein 3 | 2.0867 |
| PKN1 | protein kinase N1 | 2.07168 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| COG2 | component of oligomeric golgi complex 2 | -5.27125 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.0271 |
| LDHD | lactate dehydrogenase D | -4.88985 |
| MAP7 | microtubule-associated protein 7 | -4.36078 |
| NRIP1 | nuclear receptor interacting protein 1 | -3.93125 |
| GNAS | GNAS complex locus | -3.69929 |
| LOC102725023 | killer cell immunoglobulin-like receptor 2DS3 allele 0020101 | -2.63025 |
| KIR2DL4 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | -2.61858 |
| KIR3DL3 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | -2.6177 |
| SLC25A20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | -2.6053 |
| SLC35F2 | solute carrier family 35, member F2 | -2.54945 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.5284 |
| KIR2DS4 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 | -2.49335 |
| ZNF282 | zinc finger protein 282 | -2.4645 |
| WDR7 | WD repeat domain 7 | -2.44335 |
| MANSC1 | MANSC domain containing 1 | -2.4256 |
| HMBOX1 | homeobox containing 1 | -2.4252 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | -2.3908 |
| GUK1 | guanylate kinase 1 | -2.36345 |
| PIGT | phosphatidylinositol glycan anchor biosynthesis, class T | -2.32755 |
| S1PR5 | sphingosine-1-phosphate receptor 5 | -2.295 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | -2.28375 |
| HHIPL2 | HHIP-like 2 | -2.24645 |
| SPAG4 | sperm associated antigen 4 | -2.233 |
| FCHO1 | FCH domain only 1 | -2.22755 |
| SHPK | sedoheptulokinase | -2.16825 |
| KLHL35 | kelch-like family member 35 | -2.12835 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | -2.1219 |
| PROZ | protein Z, vitamin K-dependent plasma glycoprotein | -2.1171 |
| CCDC25 | coiled-coil domain containing 25 | -2.1089 |
| FTCD | formimidoyltransferase cyclodeaminase | -2.1086 |
| ZNF467 | zinc finger protein 467 | -2.0945 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.08308 |
| ETFDH | electron-transferring-flavoprotein dehydrogenase | -2.08278 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -2.07925 |
| CUL7 | cullin 7 | -2.0786 |
| KIR2DS2 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | -2.06182 |
| MARK1 | MAP/microtubule affinity-regulating kinase 1 | -2.0553 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | -2.05448 |
| SLC8A2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | -2.0534 |
| ECEL1 | endothelin converting enzyme-like 1 | -2.04645 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -2.0391 |
| OXR1 | oxidation resistance 1 | -2.03245 |
| CAPN15 | calpain 15 | -2.0296 |
| AGRP | agouti related neuropeptide | -2.02455 |
| MECP2 | methyl CpG binding protein 2 | -2.0169 |
| DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | -2.012 |
