| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-vinylpyrrolidone-2 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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100 genes differentially expressed following the CRCGN011_HEPG2_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 6.36815 |
| BZW2 | basic leucine zipper and W2 domains 2 | 5.35525 |
| CHMP6 | charged multivesicular body protein 6 | 5.2653 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 5.0816 |
| CSK | c-src tyrosine kinase | 4.66275 |
| KLHL9 | kelch-like family member 9 | 3.93248 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.89348 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.6566 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.65538 |
| MELK | maternal embryonic leucine zipper kinase | 3.57035 |
| PFKL | phosphofructokinase, liver | 3.55162 |
| TLR4 | toll-like receptor 4 | 3.37235 |
| CHN1 | chimerin 1 | 3.3223 |
| ATP11B | ATPase, class VI, type 11B | 3.32015 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.30155 |
| CRTAP | cartilage associated protein | 3.23825 |
| CCNF | cyclin F | 3.2185 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.06605 |
| RNF167 | ring finger protein 167 | 2.85875 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.8392 |
| TMSB15C | thymosin beta 15C | 2.79705 |
| COQ8A | coenzyme Q8A | 2.7323 |
| MYNN | myoneurin | 2.67145 |
| NOSIP | nitric oxide synthase interacting protein | 2.55305 |
| USP21 | ubiquitin specific peptidase 21 | 2.513 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.5011 |
| HSPA14 | heat shock 70kDa protein 14 | 2.494 |
| SCHIP1 | schwannomin interacting protein 1 | 2.4691 |
| MSRA | methionine sulfoxide reductase A | 2.43615 |
| BAX | BCL2-associated X protein | 2.3922 |
| LCN2 | lipocalin 2 | 2.3334 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 | 2.3177 |
| CREB1 | cAMP responsive element binding protein 1 | 2.27038 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 2.22885 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.1971 |
| PCDHB3 | protocadherin beta 3 | 2.19525 |
| PCDHB13 | protocadherin beta 13 | 2.18365 |
| PFKP | phosphofructokinase, platelet | 2.17875 |
| PSME3IP1 | proteasome activator subunit 3 interacting protein 1 | 2.1719 |
| DEK | DEK proto-oncogene | 2.1445 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 2.08955 |
| GPM6B | glycoprotein M6B | 2.08068 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | 2.06885 |
| ADNP | activity-dependent neuroprotector homeobox | 2.0529 |
| ASPSCR1 | alveolar soft part sarcoma chromosome region, candidate 1 | 2.04775 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 2.0435 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 2.0251 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 2.018 |
| ZSCAN16 | zinc finger and SCAN domain containing 16 | 2.0148 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -8.46415 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -5.81105 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.2862 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.1283 |
| LDHD | lactate dehydrogenase D | -5.07605 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.06675 |
| CDC20 | cell division cycle 20 | -5.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.458 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.25145 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -4.0951 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.77093 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.76815 |
| TCTN1 | tectonic family member 1 | -3.76015 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.59395 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.41 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -3.34803 |
| VDAC1 | voltage-dependent anion channel 1 | -3.3423 |
| PEG10 | paternally expressed 10 | -3.02728 |
| IPO13 | importin 13 | -3.01815 |
| BLCAP | bladder cancer associated protein | -3.0051 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -2.89028 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -2.8448 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.81938 |
| TMEM97 | transmembrane protein 97 | -2.81236 |
| HEATR1 | HEAT repeat containing 1 | -2.75213 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.7326 |
| PRPF4 | pre-mRNA processing factor 4 | -2.66055 |
| OSR2 | odd-skipped related transciption factor 2 | -2.55915 |
| SOAT2 | sterol O-acyltransferase 2 | -2.4649 |
| MRPS15 | mitochondrial ribosomal protein S15 | -2.45185 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -2.4284 |
| LIAS | lipoic acid synthetase | -2.3142 |
| DHCR24 | 24-dehydrocholesterol reductase | -2.25995 |
| EMILIN1 | elastin microfibril interfacer 1 | -2.2574 |
| SSRP1 | structure specific recognition protein 1 | -2.22122 |
| CHMP4B | charged multivesicular body protein 4B | -2.1545 |
| GOLT1A | golgi transport 1A | -2.15075 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -2.1283 |
| AMPD1 | adenosine monophosphate deaminase 1 | -2.12525 |
| PRND | prion protein 2 (dublet) | -2.1229 |
| SCML1 | sex comb on midleg-like 1 (Drosophila) | -2.1214 |
| MYH9 | myosin, heavy chain 9, non-muscle | -2.1173 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -2.1052 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -2.0684 |
| NID2 | nidogen 2 (osteonidogen) | -2.043 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -2.0383 |
| IRS1 | insulin receptor substrate 1 | -2.0375 |
| MRPS17 | mitochondrial ribosomal protein S17 | -2.0366 |
| ERG28 | ergosterol biosynthesis 28 homolog | -2.03457 |
| TSPAN8 | tetraspanin 8 | -2.0138 |
| ALLC | allantoicase | -2.01 |
