CRCGN011_HEPG2_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geranyl acetate 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN011_HEPG2_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.19675
TREM1 triggering receptor expressed on myeloid cells 1 4.92445
E2F2 E2F transcription factor 2 4.9236
DHDDS dehydrodolichyl diphosphate synthase 4.7565
TLR4 toll-like receptor 4 4.6374
UBQLN2 ubiquilin 2 4.5428
NMU neuromedin U 4.42405
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.34685
PEX11A peroxisomal biogenesis factor 11 alpha 4.2768
MOK MOK protein kinase 3.8103
SSBP2 single-stranded DNA binding protein 2 3.73395
CCNA1 cyclin A1 3.7137
IDE insulin-degrading enzyme 3.29603
PRR15L proline rich 15-like 3.2903
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2105
GPC1 glypican 1 3.018
CYCS cytochrome c, somatic 3.0059
LEP leptin 2.9008
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.8906
ITGA7 integrin, alpha 7 2.88745
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.6939
HLA-DRA major histocompatibility complex, class II, DR alpha 2.62867
PLIN1 perilipin 1 2.62585
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.60648
CNN3 calponin 3, acidic 2.54885
NSUN5 NOP2/Sun domain family, member 5 2.45057
ADIPOQ adiponectin, C1Q and collagen domain containing 2.4232
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.39965
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.38825
DIPK1A divergent protein kinase domain 1A 2.3802
CCL27 chemokine (C-C motif) ligand 27 2.35705
LCN2 lipocalin 2 2.3378
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 2.31673
ADAT1 adenosine deaminase, tRNA-specific 1 2.3069
ATP5MF ATP synthase membrane subunit f 2.2923
LHFPL6 LHFPL tetraspan subfamily member 6 2.27885
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.2536
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.25135
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.2499
FBXL8 F-box and leucine-rich repeat protein 8 2.2436
HOXA3 homeobox A3 2.2333
CD28 CD28 molecule 2.22942
CKMT1A creatine kinase, mitochondrial 1A 2.2291
SPINK1 serine peptidase inhibitor, Kazal type 1 2.22905
CIDEA cell death-inducing DFFA-like effector a 2.22475
CROT carnitine O-octanoyltransferase 2.22095
AQP7 aquaporin 7 2.19965
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.1991
EPHA3 EPH receptor A3 2.18823
TLX1 T-cell leukemia homeobox 1 2.1602
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.1429
CDO1 cysteine dioxygenase type 1 2.13525
PGAP3 post-GPI attachment to proteins 3 2.12812
SPAG8 sperm associated antigen 8 2.1264
POLI polymerase (DNA directed) iota 2.1263
LIN7A lin-7 homolog A (C. elegans) 2.1237
GPR15 G protein-coupled receptor 15 2.1183
CA4 carbonic anhydrase IV 2.11162
CIDEC cell death-inducing DFFA-like effector c 2.104
NOL10 nucleolar protein 10 2.10375
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.09825
TBL1Y transducin (beta)-like 1, Y-linked 2.09605
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.09185
BIRC2 baculoviral IAP repeat containing 2 2.07875
DEFA3 defensin, alpha 3, neutrophil-specific 2.07785
UBASH3A ubiquitin associated and SH3 domain containing A 2.0676
PADI2 peptidyl arginine deiminase, type II 2.0607
ARHGAP15 Rho GTPase activating protein 15 2.05145
ACACB acetyl-CoA carboxylase beta 2.04665
CD226 CD226 molecule 2.0444
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.04145
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.03912
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.02445
IFT54 intraflagellar transport 54 2.0209
CNTNAP2 contactin associated protein-like 2 2.00885
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 2.0067
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.0038

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.919
KDM3A lysine (K)-specific demethylase 3A -5.54725
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.1095
DNM1L dynamin 1-like -5.0
C2CD5 C2 calcium-dependent domain containing 5 -4.93665
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.76335
FBXL12 F-box and leucine-rich repeat protein 12 -4.6324
MAP7 microtubule-associated protein 7 -4.39063
HAT1 histone acetyltransferase 1 -4.215
MAPK13 mitogen-activated protein kinase 13 -3.99285
EIF5 eukaryotic translation initiation factor 5 -3.7377
BMP4 bone morphogenetic protein 4 -3.72085
HMG20B high mobility group 20B -3.70778
SLC35F2 solute carrier family 35, member F2 -3.3042
NRIP1 nuclear receptor interacting protein 1 -3.23545
SNX11 sorting nexin 11 -2.60295
PRPF4 pre-mRNA processing factor 4 -2.39885
RNF167 ring finger protein 167 -2.31315
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.3096
OXA1L oxidase (cytochrome c) assembly 1-like -2.30165
HEXIM1 hexamethylene bis-acetamide inducible 1 -2.26542
CCDC51 coiled-coil domain containing 51 -2.2618
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.20995
ACAA1 acetyl-CoA acyltransferase 1 -2.18635
FOXL2 forkhead box L2 -2.02225