CRCGN011_HEPG2_24H:D15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geranyl acetate 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN011_HEPG2_24H:D15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
CCL2 chemokine (C-C motif) ligand 2 7.59785
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.86625
CXCL2 chemokine (C-X-C motif) ligand 2 5.0762
SYNE2 spectrin repeat containing, nuclear envelope 2 4.98515
CSK c-src tyrosine kinase 4.91515
TREM1 triggering receptor expressed on myeloid cells 1 4.7947
LOC122526780 uncharacterized LOC122526780 4.58375
MCOLN1 mucolipin 1 4.5631
PPARG peroxisome proliferator-activated receptor gamma 4.45675
SSBP2 single-stranded DNA binding protein 2 3.64255
CYCS cytochrome c, somatic 3.50615
CHN1 chimerin 1 3.27145
TIAM1 T-cell lymphoma invasion and metastasis 1 2.71285
GPATCH8 G patch domain containing 8 2.38085
ABHD4 abhydrolase domain containing 4 2.2864
WHR1 winged helix repair factor 1 2.25078
LOXL1 lysyl oxidase-like 1 2.2347
SKIC2 SKI2 subunit of superkiller complex 2.2138
JADE2 jade family PHD finger 2 2.17295
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.15845
HLA-DRA major histocompatibility complex, class II, DR alpha 2.1165
CHEK2 checkpoint kinase 2 2.08172
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.0659
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.0448
RBKS ribokinase 2.0374

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.17475
CDC20 cell division cycle 20 -4.66275
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.21305
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.88
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.83915
DERA deoxyribose-phosphate aldolase (putative) -3.4328
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.15307
CCNB2 cyclin B2 -2.88965
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.65908
SLC35F2 solute carrier family 35, member F2 -2.64295
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.61964
LOC124907782 dual specificity protein phosphatase 22 -2.54825
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 -2.48135
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.4161
GPR68 G protein-coupled receptor 68 -2.39855
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.26373
ARID5B AT rich interactive domain 5B (MRF1-like) -2.2425
CXCL11 chemokine (C-X-C motif) ligand 11 -2.21425
NGRN neugrin, neurite outgrowth associated -2.18345
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -2.17725
ANKRD40CL ANKRD40 C-terminal like -2.17365
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.15278
POU3F3 POU class 3 homeobox 3 -2.12155
FOXB1 forkhead box B1 -2.1093
CLEC2D C-type lectin domain family 2, member D -2.10205
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.08305
GSC2 goosecoid homeobox 2 -2.03465
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.02915
NEUROG2 neurogenin 2 -2.0274
SCRT1 scratch family zinc finger 1 -2.02255
H1-1 H1.1 linker histone, cluster member -2.0023