CRCGN011_HEPG2_24H:D16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description geranyl acetate 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN011_HEPG2_24H:D16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 9.07675
GSTZ1 glutathione S-transferase zeta 1 6.75135
PNKP polynucleotide kinase 3'-phosphatase 5.9723
MSRA methionine sulfoxide reductase A 5.4369
SQOR sulfide quinone oxidoreductase 5.40045
INTS3 integrator complex subunit 3 5.3935
MYLK myosin light chain kinase 5.3646
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.1544
PPARG peroxisome proliferator-activated receptor gamma 4.7044
UBQLN2 ubiquilin 2 4.69185
STK10 serine/threonine kinase 10 4.45337
TLR4 toll-like receptor 4 4.4307
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.27975
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.45285
LOC122526780 uncharacterized LOC122526780 3.1646
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.8799
JADE2 jade family PHD finger 2 2.82505
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.58965
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.5839
ILK integrin-linked kinase 2.5592
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.55125
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.51175
COQ8A coenzyme Q8A 2.46585
EVL Enah/Vasp-like 2.4399
GLRB glycine receptor, beta 2.3328
HAVCR1 hepatitis A virus cellular receptor 1 2.27335
ACP6 acid phosphatase 6, lysophosphatidic 2.21045
NELFE negative elongation factor complex member E 2.2091
FOXA2 forkhead box A2 2.20533
GPATCH8 G patch domain containing 8 2.20125
SEH1L SEH1-like (S. cerevisiae) 2.19605
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.18675
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 2.15845
ABT1 activator of basal transcription 1 2.14505
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.13935
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 2.13785
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.13765
GSTK1 glutathione S-transferase kappa 1 2.12865
MTCH1 mitochondrial carrier 1 2.12135
MRPL9 mitochondrial ribosomal protein L9 2.11705
MMP8 matrix metallopeptidase 8 2.1015
BAG6 BCL2-associated athanogene 6 2.09902
PZP pregnancy-zone protein 2.07385
VLDLR very low density lipoprotein receptor 2.07205
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.041
ADAR adenosine deaminase, RNA-specific 2.0377
OASL 2'-5'-oligoadenylate synthetase-like 2.02992
IFI35 interferon-induced protein 35 2.0246
CMTR1 cap methyltransferase 1 2.0176
HKDC1 hexokinase domain containing 1 2.0154
TMEM101 transmembrane protein 101 2.01535
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.0152
TAC3 tachykinin 3 2.0074
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.0022
BZW2 basic leucine zipper and W2 domains 2 2.00205

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -7.65425
CCNB2 cyclin B2 -7.5556
COG7 component of oligomeric golgi complex 7 -5.66945
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.04745
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
NT5DC2 5'-nucleotidase domain containing 2 -5.0
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -4.8743
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.82435
ACOT9 acyl-CoA thioesterase 9 -4.62515
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6109
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -4.00868
PCNA proliferating cell nuclear antigen -3.0549
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.00505
RNF167 ring finger protein 167 -2.8886
BCL7C B-cell CLL/lymphoma 7C -2.83245
TLCD3A TLC domain containing 3A -2.71455
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.68157
VDAC1 voltage-dependent anion channel 1 -2.47275
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.46035
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.38065
CSNK1E casein kinase 1, epsilon -2.37008
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.34627
DCTPP1 dCTP pyrophosphatase 1 -2.3313
DROSHA drosha, ribonuclease type III -2.32425
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.2756
CLTB clathrin, light chain B -2.24901
PALB2 partner and localizer of BRCA2 -2.2248
PRR11 proline rich 11 -2.1829
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.1806
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.16862
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.1434
UBFD1 ubiquitin family domain containing 1 -2.12295
DENND4C DENN/MADD domain containing 4C -2.0954
MSMO1 methylsterol monooxygenase 1 -2.0683
PRR14 proline rich 14 -2.06768
ERI2 ERI1 exoribonuclease family member 2 -2.06545
LOC127933115 uncharacterized LOC127933115 -2.06285
HAUS2 HAUS augmin-like complex, subunit 2 -2.06075
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.05225
FSCN1 fascin actin-bundling protein 1 -2.04932
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.0419
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.0152
CRYBG3 beta-gamma crystallin domain containing 3 -2.01455