CRCGN011_HEPG2_24H:D21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trans-cinnamaldehyde 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN011_HEPG2_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.8626
AMDHD2 amidohydrolase domain containing 2 5.53775
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.4559
RPL39L ribosomal protein L39-like 5.29435
CIAO3 cytosolic iron-sulfur assembly component 3 4.9894
KDM5A lysine (K)-specific demethylase 5A 4.82005
STK10 serine/threonine kinase 10 4.78947
SNAP25 synaptosomal-associated protein, 25kDa 4.59262
ABHD6 abhydrolase domain containing 6 3.99687
CCL2 chemokine (C-C motif) ligand 2 3.94445
COL11A1 collagen, type XI, alpha 1 3.8503
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.77855
CHN1 chimerin 1 3.7348
FZD7 frizzled class receptor 7 3.64682
JADE2 jade family PHD finger 2 3.3806
GATA3 GATA binding protein 3 3.34792
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.28195
NMU neuromedin U 3.216
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.18853
PECR peroxisomal trans-2-enoyl-CoA reductase 3.08205
CYCS cytochrome c, somatic 2.8697
PRR15L proline rich 15-like 2.86945
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.6736
FSHB follicle stimulating hormone, beta polypeptide 2.5705
MXRA8 matrix-remodelling associated 8 2.41775
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.40692
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.39322
NENF neudesin neurotrophic factor 2.36215
OLFML3 olfactomedin-like 3 2.29335
INKA2 inka box actin regulator 2 2.2681
DRD4 dopamine receptor D4 2.25725
CSHL1 chorionic somatomammotropin hormone-like 1 2.19181
RPS26 ribosomal protein S26 2.1857
GRAMD1B GRAM domain containing 1B 2.1522
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.1502
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.13975
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa 2.1339
LMOD1 leiomodin 1 (smooth muscle) 2.1179
TXLNA taxilin alpha 2.1098
ATP5F1C ATP synthase F1 subunit gamma 2.10142
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.10135
POMC proopiomelanocortin 2.1013
NBEAL2 neurobeachin-like 2 2.07635
ZNF268 zinc finger protein 268 2.0531
ZBTB35 zinc finger and BTB domain containing 35 2.03395
MEGF6 multiple EGF-like-domains 6 2.0323
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.0293
LHB luteinizing hormone beta polypeptide 2.0203
DAO D-amino-acid oxidase 2.00505

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.17985
CCNB2 cyclin B2 -8.30835
GDF15 growth differentiation factor 15 -6.1117
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.58055
TRIB3 tribbles pseudokinase 3 -5.14015
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.109
CCDC86 coiled-coil domain containing 86 -5.0039
GOLT1B golgi transport 1B -4.9818
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.78075
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6109
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.56665
MAP7 microtubule-associated protein 7 -4.4724
HMG20B high mobility group 20B -3.90462
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.6998
ARID5B AT rich interactive domain 5B (MRF1-like) -3.09485
OXA1L oxidase (cytochrome c) assembly 1-like -2.7625
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.65065
EXT1 exostosin glycosyltransferase 1 -2.47512
NGRN neugrin, neurite outgrowth associated -2.4467
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.33495
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.2698
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.1284