CRCGN011_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trans-cinnamaldehyde 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN011_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.08755
CXCL2 chemokine (C-X-C motif) ligand 2 5.32315
PHKG2 phosphorylase kinase, gamma 2 (testis) 5.0875
UBQLN2 ubiquilin 2 5.0082
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9838
E2F2 E2F transcription factor 2 4.86675
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4798
INTS3 integrator complex subunit 3 4.347
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 4.27325
FZD7 frizzled class receptor 7 4.20835
SOCS2 suppressor of cytokine signaling 2 4.12325
HDGFL3 HDGF like 3 4.09825
PEX11A peroxisomal biogenesis factor 11 alpha 4.09078
MAP7 microtubule-associated protein 7 3.88137
SSBP2 single-stranded DNA binding protein 2 3.6038
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.50402
RXYLT1 ribitol xylosyltransferase 1 3.42838
TIAM1 T-cell lymphoma invasion and metastasis 1 3.37302
PCDHB11 protocadherin beta 11 3.11252
KLHL9 kelch-like family member 9 2.94855
SIRT3 sirtuin 3 2.84538
COL11A1 collagen, type XI, alpha 1 2.62675
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 2.5786
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.55295
BTK Bruton agammaglobulinemia tyrosine kinase 2.53805
HIRIP3 HIRA interacting protein 3 2.5215
CEP57 centrosomal protein 57kDa 2.47918
PER3 period circadian clock 3 2.44685
RHAG Rh-associated glycoprotein 2.42597
RIC8A RIC8 guanine nucleotide exchange factor A 2.3845
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.35543
DSE dermatan sulfate epimerase 2.3214
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.18945
NUP133 nucleoporin 133kDa 2.1731
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.1699
GPER1 G protein-coupled estrogen receptor 1 2.15402
RETREG1 reticulophagy regulator 1 2.15048
GOLPH3L golgi phosphoprotein 3-like 2.1453
IL10 interleukin 10 2.14165
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.1188
KLHL12 kelch-like family member 12 2.11705
TRA2B transformer 2 beta homolog (Drosophila) 2.10998
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.10205
MED27 mediator complex subunit 27 2.07728
CREB3L4 cAMP responsive element binding protein 3-like 4 2.07495
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.0597
PAQR5 progestin and adipoQ receptor family member V 2.0583
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.05675
FAM110B family with sequence similarity 110, member B 2.05015
RBM22 RNA binding motif protein 22 2.0492
BLNK B-cell linker 2.03975
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.02935
LOC128966622 putative protein N-methyltransferase FAM86B2 2.0068
CDKN2AIP CDKN2A interacting protein 2.0013

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -6.2321
KDM3A lysine (K)-specific demethylase 3A -6.1265
PCCB propionyl CoA carboxylase, beta polypeptide -5.3892
DNM1L dynamin 1-like -5.0449
ACAA1 acetyl-CoA acyltransferase 1 -5.03425
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.0228
GDF15 growth differentiation factor 15 -5.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.9824
NUP85 nucleoporin 85kDa -4.9337
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.75255
LDHD lactate dehydrogenase D -4.691
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.66275
CD320 CD320 molecule -4.6528
THAP11 THAP domain containing 11 -4.61065
CTSD cathepsin D -4.14595
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.81505
SAP30BP SAP30 binding protein -3.78055
OXA1L oxidase (cytochrome c) assembly 1-like -3.74045
MACF1 microtubule-actin crosslinking factor 1 -3.55652
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -3.5527
HMG20B high mobility group 20B -3.53837
DERA deoxyribose-phosphate aldolase (putative) -3.37085
GNAS GNAS complex locus -3.35802
NRIP1 nuclear receptor interacting protein 1 -3.30578
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.2832
WASHC4 WASH complex subunit 4 -3.17577
FASTKD5 FAST kinase domains 5 -2.83495
MRPS7 mitochondrial ribosomal protein S7 -2.81575
CCNB2 cyclin B2 -2.7491
KCTD2 potassium channel tetramerization domain containing 2 -2.64988
GRN granulin -2.64865
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.64115
ATP5PD ATP synthase peripheral stalk subunit d -2.607
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.55125
SYNGR2 synaptogyrin 2 -2.5454
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.5204
RBM28 RNA binding motif protein 28 -2.4623
MRPL58 mitochondrial ribosomal protein L58 -2.38055
GSTK1 glutathione S-transferase kappa 1 -2.3517
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.34845
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.3169
HEATR1 HEAT repeat containing 1 -2.29015
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.2874
PTCD3 pentatricopeptide repeat domain 3 -2.2801
UBE2O ubiquitin-conjugating enzyme E2O -2.2495
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.2131
TEAD4 TEA domain family member 4 -2.2069
SLC38A12 solute carrier family 38 member 12 -2.17995
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -2.163
ABHD17A abhydrolase domain containing 17A -2.1514
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.14505
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.14185
IPO13 importin 13 -2.1339
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.11455
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.08168
TRADD TNFRSF1A-associated via death domain -2.04688
SDAD1 SDA1 domain containing 1 -2.04405
MGA MGA, MAX dimerization protein -2.02655
PEBP1 phosphatidylethanolamine binding protein 1 -2.016
AMDHD2 amidohydrolase domain containing 2 -2.01505
CHIC2 cysteine-rich hydrophobic domain 2 -2.01435