| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-amino-3-oxo-3h-phenoxazine-1,9-dicarboxylic acid 19.98 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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125 genes differentially expressed following the CRCGN011_HEPG2_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 5.13985 |
| MYLK | myosin light chain kinase | 5.06685 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.04065 |
| CTSL | cathepsin L | 4.8832 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.68635 |
| LCN2 | lipocalin 2 | 4.61755 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 4.37715 |
| HOXA10 | homeobox A10 | 4.31378 |
| CBR3 | carbonyl reductase 3 | 4.14985 |
| ATP11B | ATPase, class VI, type 11B | 4.07985 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 4.0131 |
| MAP7 | microtubule-associated protein 7 | 4.01137 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.9272 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.90465 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.84958 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 3.82545 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.8227 |
| SKIC2 | SKI2 subunit of superkiller complex | 3.79205 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.7682 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.72945 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 3.6638 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.2156 |
| JADE2 | jade family PHD finger 2 | 2.90057 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.89755 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | 2.89167 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.88028 |
| PRR15L | proline rich 15-like | 2.83085 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.78465 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.78055 |
| HSPA1A | heat shock 70kDa protein 1A | 2.74385 |
| PMM2 | phosphomannomutase 2 | 2.69605 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.62232 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.6062 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.60455 |
| FASTKD5 | FAST kinase domains 5 | 2.5383 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.5119 |
| MRPL15 | mitochondrial ribosomal protein L15 | 2.4659 |
| RIBC2 | RIB43A domain with coiled-coils 2 | 2.42515 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 2.40445 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 2.37185 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.362 |
| MVP | major vault protein | 2.3376 |
| TXNRD1 | thioredoxin reductase 1 | 2.31525 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.3086 |
| TAF9 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa | 2.28455 |
| MNMIP1 | manchette microtubule inner protein 1 | 2.23235 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | 2.22802 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.21095 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | 2.20372 |
| CCNF | cyclin F | 2.17622 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.17395 |
| CDK2 | cyclin-dependent kinase 2 | 2.1706 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | 2.16095 |
| HOXB7 | homeobox B7 | 2.15082 |
| ABHD10 | abhydrolase domain containing 10 | 2.148 |
| RWDD1 | RWD domain containing 1 | 2.13615 |
| VPS35L | VPS35 endosomal protein sorting factor like | 2.11665 |
| ATG3 | autophagy related 3 | 2.1137 |
| SPX | spexin hormone | 2.1061 |
| NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 2.08745 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 2.05365 |
| STX18 | syntaxin 18 | 2.0525 |
| HMOX1 | heme oxygenase 1 | 2.04245 |
| GJB1 | gap junction protein, beta 1, 32kDa | 2.03185 |
| CTRC | chymotrypsin C (caldecrin) | 2.0264 |
| GOLM1 | golgi membrane protein 1 | 2.0104 |
| NDFIP1 | Nedd4 family interacting protein 1 | 2.00515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -8.5497 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.83095 |
| LDHD | lactate dehydrogenase D | -4.801 |
| THAP11 | THAP domain containing 11 | -4.75165 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.734 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.6256 |
| TLCD3A | TLC domain containing 3A | -4.5548 |
| CCDC86 | coiled-coil domain containing 86 | -4.4617 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.3102 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.84942 |
| CCNB2 | cyclin B2 | -3.7123 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.6354 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.45415 |
| ZNF274 | zinc finger protein 274 | -3.4037 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -3.25635 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -3.0805 |
| ALDOC | aldolase C, fructose-bisphosphate | -3.02275 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.9527 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | -2.9397 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.71347 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.64323 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -2.5177 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.46905 |
| KIF14 | kinesin family member 14 | -2.38065 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -2.36795 |
| CRYAB | crystallin, alpha B | -2.3671 |
| HEATR1 | HEAT repeat containing 1 | -2.3669 |
| NLGN4X | neuroligin 4, X-linked | -2.3524 |
| NMRK1 | nicotinamide riboside kinase 1 | -2.347 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -2.33515 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.29644 |
| GID8 | GID complex subunit 8 | -2.2945 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -2.27795 |
| FAM20B | family with sequence similarity 20, member B | -2.26363 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -2.22945 |
| IL10RA | interleukin 10 receptor, alpha | -2.2287 |
| ACLY | ATP citrate lyase | -2.21923 |
| QSER1 | glutamine and serine rich 1 | -2.20465 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -2.16455 |
| VPS33A | vacuolar protein sorting 33 homolog A (S. cerevisiae) | -2.15725 |
| METTL2A | methyltransferase like 2A | -2.15425 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.14952 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.1396 |
| CA3 | carbonic anhydrase III | -2.1358 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -2.1182 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -2.0934 |
| TPM3 | tropomyosin 3 | -2.0704 |
| CNN2 | calponin 2 | -2.06755 |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase | -2.06145 |
| L2HGDH | L-2-hydroxyglutarate dehydrogenase | -2.05005 |
| ACTA1 | actin, alpha 1, skeletal muscle | -2.04895 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -2.03545 |
| PEX12 | peroxisomal biogenesis factor 12 | -2.02975 |
| CDC42 | cell division cycle 42 | -2.02631 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | -2.02585 |
| PGK1 | phosphoglycerate kinase 1 | -2.02253 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -2.00485 |
| WWC2 | WW and C2 domain containing 2 | -2.00405 |
