CRCGN011_HEPG2_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-3-oxo-3h-phenoxazine-1,9-dicarboxylic acid 9.99 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 8.6766
CSK c-src tyrosine kinase 5.66055
GPATCH8 G patch domain containing 8 5.4458
PPARG peroxisome proliferator-activated receptor gamma 5.1175
LCN2 lipocalin 2 5.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.90545
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8712
NMU neuromedin U 4.8472
UBQLN2 ubiquilin 2 4.3737
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.33195
E2F2 E2F transcription factor 2 4.31855
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.3097
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.10155
ADGRE5 adhesion G protein-coupled receptor E5 3.7591
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.7394
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.69355
LOC122526780 uncharacterized LOC122526780 3.3914
DMTF1 cyclin D binding myb-like transcription factor 1 3.31455
CEMIP2 cell migration inducing hyaluronidase 2 2.8645
SSBP2 single-stranded DNA binding protein 2 2.84777
CHEK2 checkpoint kinase 2 2.81067
ANKRD17 ankyrin repeat domain 17 2.68715
GPER1 G protein-coupled estrogen receptor 1 2.64952
RBM4B RNA binding motif protein 4B 2.6196
MX2 MX dynamin-like GTPase 2 2.6142
HMGA2 high mobility group AT-hook 2 2.51865
FASTKD5 FAST kinase domains 5 2.44635
GSTZ1 glutathione S-transferase zeta 1 2.40495
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.37815
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.31925
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.27865
SNX7 sorting nexin 7 2.2521
TREM1 triggering receptor expressed on myeloid cells 1 2.24585
HROB homologous recombination factor with OB-fold 2.2402
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.23325
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 2.22355
TP53BP1 tumor protein p53 binding protein 1 2.22137
CTSH cathepsin H 2.22005
NINL ninein-like 2.2034
HPD 4-hydroxyphenylpyruvate dioxygenase 2.1954
MACROH2A2 macroH2A.2 histone 2.18475
USPL1 ubiquitin specific peptidase like 1 2.16885
SOBP sine oculis binding protein homolog (Drosophila) 2.1685
DIPK1A divergent protein kinase domain 1A 2.15138
IFI44 interferon-induced protein 44 2.1239
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.11855
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.11265
CNKSR3 CNKSR family member 3 2.1013
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.0998
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.09175
VAT1 vesicle amine transport 1 2.0857
ZBTB25 zinc finger and BTB domain containing 25 2.07865
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.07685
IFI44L interferon-induced protein 44-like 2.0751
SLC25A46 solute carrier family 25, member 46 2.07495
TAC1 tachykinin, precursor 1 2.07255
ASCC3 activating signal cointegrator 1 complex subunit 3 2.07235
KCTD14 potassium channel tetramerization domain containing 14 2.06703
HBA1 hemoglobin, alpha 1 2.06037
UNC93B1 unc-93 homolog B1 (C. elegans) 2.0405
GAGE1 G antigen 1 2.0387
RNF38 ring finger protein 38 2.02415
PTPRS protein tyrosine phosphatase, receptor type, S 2.0225
MAB21L2 mab-21-like 2 (C. elegans) 2.0187

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
KDM3A lysine (K)-specific demethylase 3A -6.1022
MRPS2 mitochondrial ribosomal protein S2 -5.01945
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.9593
MAP7 microtubule-associated protein 7 -4.79525
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.652
RGS2 regulator of G-protein signaling 2 -4.4591
WASHC4 WASH complex subunit 4 -3.55967
GRWD1 glutamate-rich WD repeat containing 1 -3.3645
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.07951
CCNB2 cyclin B2 -2.88855
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.73487
ZNF274 zinc finger protein 274 -2.6395
BAALC brain and acute leukemia, cytoplasmic -2.57255
TCEAL4 transcription elongation factor A (SII)-like 4 -2.43635
TRAPPC6A trafficking protein particle complex 6A -2.3346
COMMD8 COMM domain containing 8 -2.32035
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.2966
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.26925
TSNAX translin-associated factor X -2.2508
CTSD cathepsin D -2.22915
CHPF chondroitin polymerizing factor -2.22455
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.19765
H2AC25 H2A clustered histone 25 -2.18545
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.16765
HLA-DMA major histocompatibility complex, class II, DM alpha -2.13235
DDIT4 DNA-damage-inducible transcript 4 -2.12985
ZNF768 zinc finger protein 768 -2.08305
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.05805
CPNE3 copine III -2.05457
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.05415
HEATR1 HEAT repeat containing 1 -2.0451
GLIPR1 GLI pathogenesis-related 1 -2.0388
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.0357
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.02987
REXO5 RNA exonuclease 5 -2.0257
ITGB1BP1 integrin beta 1 binding protein 1 -2.01335
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.01275
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.01095