| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-amino-3-oxo-3h-phenoxazine-1,9-dicarboxylic acid 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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80 genes differentially expressed following the CRCGN011_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.8684 |
| RPL39L | ribosomal protein L39-like | 5.41695 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.3925 |
| MYLK | myosin light chain kinase | 5.25155 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.1203 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.94925 |
| CSK | c-src tyrosine kinase | 4.66275 |
| E2F2 | E2F transcription factor 2 | 4.648 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.52185 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 4.23325 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.8845 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.7101 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.66715 |
| ABHD6 | abhydrolase domain containing 6 | 3.55317 |
| CCNA1 | cyclin A1 | 3.3365 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.29825 |
| FZD7 | frizzled class receptor 7 | 3.25068 |
| TXNL4B | thioredoxin-like 4B | 3.05115 |
| CHN1 | chimerin 1 | 2.8793 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.8163 |
| CHEK2 | checkpoint kinase 2 | 2.81362 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.51258 |
| GPATCH8 | G patch domain containing 8 | 2.4093 |
| EDN1 | endothelin 1 | 2.36355 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.3436 |
| VEGFC | vascular endothelial growth factor C | 2.3082 |
| FASTKD5 | FAST kinase domains 5 | 2.28265 |
| RIPPLY2-CYB5R4 | RIPPLY2-CYB5R4 readthrough | 2.27845 |
| DIPK1A | divergent protein kinase domain 1A | 2.2674 |
| GALE | UDP-galactose-4-epimerase | 2.16685 |
| HSPA1A | heat shock 70kDa protein 1A | 2.1034 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 2.10033 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 2.088 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 2.0561 |
| GPR183 | G protein-coupled receptor 183 | 2.0344 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.02665 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | -7.52752 |
| PIK3R4 | phosphoinositide-3-kinase, regulatory subunit 4 | -5.4296 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -5.41305 |
| TUBB6 | tubulin, beta 6 class V | -5.21945 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.6578 |
| CCNB2 | cyclin B2 | -4.5775 |
| CCNB1 | cyclin B1 | -4.4151 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.8402 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -3.59938 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.38045 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.27885 |
| RBM34 | RNA binding motif protein 34 | -3.24138 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -3.11075 |
| WASHC4 | WASH complex subunit 4 | -3.0772 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -3.05157 |
| RNF167 | ring finger protein 167 | -2.9051 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.7318 |
| SNX11 | sorting nexin 11 | -2.64425 |
| LMTK2 | lemur tyrosine kinase 2 | -2.63525 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.58625 |
| ATP9A | ATPase, class II, type 9A | -2.53925 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | -2.5312 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | -2.48235 |
| LIMD1 | LIM domains containing 1 | -2.3377 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.3301 |
| OSBP2 | oxysterol binding protein 2 | -2.27665 |
| KCNC3 | potassium channel, voltage gated Shaw related subfamily C, member 3 | -2.24915 |
| PGBD5 | piggyBac transposable element derived 5 | -2.23712 |
| RCAN3 | RCAN family member 3 | -2.17205 |
| ZNF10 | zinc finger protein 10 | -2.1523 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -2.13025 |
| RSPH6A | radial spoke head 6 homolog A (Chlamydomonas) | -2.12105 |
| ZNF556 | zinc finger protein 556 | -2.12025 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -2.1071 |
| RAB6B | RAB6B, member RAS oncogene family | -2.10455 |
| RMDN3 | regulator of microtubule dynamics 3 | -2.0945 |
| GID4 | GID complex subunit 4 | -2.07045 |
| ATG9A | autophagy related 9A | -2.07005 |
| SPRYD7 | SPRY domain containing 7 | -2.06345 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | -2.05868 |
| NPPB | natriuretic peptide B | -2.04395 |
| CRB1 | crumbs family member 1, photoreceptor morphogenesis associated | -2.0269 |
| MATN4 | matrilin 4 | -2.01155 |
| KHSRP | KH-type splicing regulatory protein | -2.00367 |
