CRCGN011_HEPG2_24H:E08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibutyltin diacetate 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

151 genes differentially expressed following the CRCGN011_HEPG2_24H:E08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.4105
CARMIL1 capping protein regulator and myosin 1 linker 1 5.23955
GFOD1 glucose-fructose oxidoreductase domain containing 1 5.15885
DENND2D DENN/MADD domain containing 2D 5.1045
ABHD4 abhydrolase domain containing 4 5.0734
RPP38 ribonuclease P/MRP 38kDa subunit 5.0702
CDPF1 cysteine-rich, DPF motif domain containing 1 5.02175
CBR3 carbonyl reductase 3 5.01275
CHMP6 charged multivesicular body protein 6 4.9182
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.80455
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.53815
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 4.51335
PPARG peroxisome proliferator-activated receptor gamma 4.367
LSR lipolysis stimulated lipoprotein receptor 4.13985
PRR15L proline rich 15-like 4.1151
HSPA1A heat shock 70kDa protein 1A 4.05745
KIF14 kinesin family member 14 4.00295
HMOX1 heme oxygenase 1 3.98155
ALAS1 5'-aminolevulinate synthase 1 3.9757
TXNRD1 thioredoxin reductase 1 3.6919
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.62435
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.4374
ASCC3 activating signal cointegrator 1 complex subunit 3 3.32855
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.1883
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.09995
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.9736
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.92665
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.79615
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.6106
BIRC2 baculoviral IAP repeat containing 2 2.6007
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.5767
MCM3 minichromosome maintenance complex component 3 2.4887
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.4557
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.45075
PARP2 poly (ADP-ribose) polymerase 2 2.4224
APOE apolipoprotein E 2.41153
TSKU tsukushi, small leucine rich proteoglycan 2.37815
ADAMTSL2 ADAMTS-like 2 2.3495
PYGL phosphorylase, glycogen, liver 2.32555
ZNF318 zinc finger protein 318 2.31317
UGDH UDP-glucose 6-dehydrogenase 2.29945
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.28275
ZNF219 zinc finger protein 219 2.25195
NR2F6 nuclear receptor subfamily 2, group F, member 6 2.2346
TATDN2 TatD DNase domain containing 2 2.21065
MAN1C1 mannosidase, alpha, class 1C, member 1 2.15903
CHEK2 checkpoint kinase 2 2.15543
STIP1 stress-induced phosphoprotein 1 2.1496
IMMT inner membrane protein, mitochondrial 2.1481
HSPB1 heat shock 27kDa protein 1 2.14415
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.14295
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.13115
MRPL34 mitochondrial ribosomal protein L34 2.1249
JADE2 jade family PHD finger 2 2.09865
MTERF3 mitochondrial transcription termination factor 3 2.0877
MFAP4 microfibrillar-associated protein 4 2.0731
ECSIT ECSIT signalling integrator 2.0554
UPK3B uroplakin 3B 2.04545
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.0377
ANKRD10 ankyrin repeat domain 10 2.0326
TALDO1 transaldolase 1 2.02465
CCP110 centriolar coiled coil protein 110kDa 2.01415
COQ9 coenzyme Q9 2.0083
GPKOW G patch domain and KOW motifs 2.0029
TKT transketolase 2.00203

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -7.2198
CD320 CD320 molecule -6.71615
IER3 immediate early response 3 -6.0539
SPAG4 sperm associated antigen 4 -5.2531
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.22115
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0572
GDF15 growth differentiation factor 15 -4.43325
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.37052
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.1674
TLCD3A TLC domain containing 3A -4.0598
DUSP6 dual specificity phosphatase 6 -4.0544
CDC25B cell division cycle 25B -3.90685
INPP1 inositol polyphosphate-1-phosphatase -3.8582
CDC20 cell division cycle 20 -3.84315
FGFR4 fibroblast growth factor receptor 4 -3.81815
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.77045
ALDOC aldolase C, fructose-bisphosphate -3.6076
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.56775
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.5109
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.4594
ZW10 zw10 kinetochore protein -3.37705
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.25602
MTFR1 mitochondrial fission regulator 1 -3.14592
TSPAN4 tetraspanin 4 -3.12918
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.05815
DDIT4 DNA-damage-inducible transcript 4 -3.01015
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.99065
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.98698
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.9316
RPIA ribose 5-phosphate isomerase A -2.79665
TSPAN5 tetraspanin 5 -2.79155
PLEK2 pleckstrin 2 -2.7754
TRIB1 tribbles pseudokinase 1 -2.76945
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.6644
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.5893
CAB39 calcium binding protein 39 -2.57605
DPY19L1 dpy-19-like 1 (C. elegans) -2.57005
LAS1L LAS1-like (S. cerevisiae) -2.4927
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -2.47323
TOMM34 translocase of outer mitochondrial membrane 34 -2.4387
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.43865
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.4343
MSTN myostatin -2.4112
CCNO cyclin O -2.4079
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.40285
TTC12 tetratricopeptide repeat domain 12 -2.3848
RNF170 ring finger protein 170 -2.32945
NUCB2 nucleobindin 2 -2.30815
DUSP5 dual specificity phosphatase 5 -2.3067
CDKN2AIP CDKN2A interacting protein -2.28335
TBCB tubulin folding cofactor B -2.26537
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.25065
TSGA10 testis specific, 10 -2.24
ANKRD37 ankyrin repeat domain 37 -2.2358
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.22405
ITGAV integrin, alpha V -2.2089
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.2034
PGM1 phosphoglucomutase 1 -2.1983
TUBB6 tubulin, beta 6 class V -2.1693
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.16915
TMEM147 transmembrane protein 147 -2.1613
CREB5 cAMP responsive element binding protein 5 -2.14965
MRPS18C mitochondrial ribosomal protein S18C -2.1479
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.1446
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.135
EDDM3A epididymal protein 3A -2.13375
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -2.12945
DCTD dCMP deaminase -2.1258
SOAT2 sterol O-acyltransferase 2 -2.10808
TSPAN2 tetraspanin 2 -2.0957
IFT54 intraflagellar transport 54 -2.0951
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.08815
PAQR6 progestin and adipoQ receptor family member VI -2.0831
PGAM4 phosphoglycerate mutase family member 4 -2.072
RPA4 replication protein A4, 30kDa -2.07175
SQOR sulfide quinone oxidoreductase -2.0595
ITGB8 integrin, beta 8 -2.0562
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.0388
PDLIM4 PDZ and LIM domain 4 -2.0381
PLAU plasminogen activator, urokinase -2.02558
THAP7 THAP domain containing 7 -2.0216
GALE UDP-galactose-4-epimerase -2.0205
IZUMO4 IZUMO family member 4 -2.01517
HDAC2 histone deacetylase 2 -2.0143
AGA aspartylglucosaminidase -2.00182
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.0009