CRCGN011_HEPG2_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibutyltin diacetate 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN011_HEPG2_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
DYNLT3 dynein, light chain, Tctex-type 3 8.4828
HMOX1 heme oxygenase 1 7.08905
PNKP polynucleotide kinase 3'-phosphatase 5.34035
BACE2 beta-site APP-cleaving enzyme 2 5.23585
PLS1 plastin 1 5.00955
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.67805
AMDHD2 amidohydrolase domain containing 2 4.6277
PPARG peroxisome proliferator-activated receptor gamma 4.5155
TREM1 triggering receptor expressed on myeloid cells 1 3.6015
CHN1 chimerin 1 3.5229
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.463
ABHD6 abhydrolase domain containing 6 3.23482
LYN LYN proto-oncogene, Src family tyrosine kinase 3.21368
TIAM1 T-cell lymphoma invasion and metastasis 1 3.16227
MAST2 microtubule associated serine/threonine kinase 2 3.03742
JADE2 jade family PHD finger 2 2.8389
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.75855
GPATCH8 G patch domain containing 8 2.7154
MAGEA6 melanoma antigen family A6 2.54653
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.5438
MEST mesoderm specific transcript 2.45115
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.4163
BIRC2 baculoviral IAP repeat containing 2 2.3889
ASCC3 activating signal cointegrator 1 complex subunit 3 2.35175
MAGEA11 melanoma antigen family A11 2.3464
SSBP2 single-stranded DNA binding protein 2 2.33677
PARP2 poly (ADP-ribose) polymerase 2 2.33377
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.3205
TSPAN13 tetraspanin 13 2.25395
EPHA3 EPH receptor A3 2.2183
BHMT2 betaine--homocysteine S-methyltransferase 2 2.1532
CD40 CD40 molecule, TNF receptor superfamily member 5 2.1262
ZNF589 zinc finger protein 589 2.05447
UCK2 uridine-cytidine kinase 2 2.0522
PPT1 palmitoyl-protein thioesterase 1 2.03465
BZW2 basic leucine zipper and W2 domains 2 2.0103

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.22035
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.66545
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.97105
DSG2 desmoglein 2 -4.9578
KDM3A lysine (K)-specific demethylase 3A -4.63035
FGFR4 fibroblast growth factor receptor 4 -4.21775
DUSP6 dual specificity phosphatase 6 -3.12288
RFC2 replication factor C (activator 1) 2, 40kDa -3.00205
INPP1 inositol polyphosphate-1-phosphatase -2.99645
IER3 immediate early response 3 -2.9012
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.5648
ACOT9 acyl-CoA thioesterase 9 -2.548
TCEAL4 transcription elongation factor A (SII)-like 4 -2.41905
SLC35F2 solute carrier family 35, member F2 -2.30565
OXA1L oxidase (cytochrome c) assembly 1-like -2.2572
KIF14 kinesin family member 14 -2.2381
MVP major vault protein -2.2363
MAP2K5 mitogen-activated protein kinase kinase 5 -2.11832
C5 complement component 5 -2.10895
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.10645
PIMREG PICALM interacting mitotic regulator -2.0824
TOMM34 translocase of outer mitochondrial membrane 34 -2.0786
OIP5 Opa interacting protein 5 -2.0771
THAP1 THAP domain containing, apoptosis associated protein 1 -2.04555