CRCGN011_HEPG2_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibutyltin diacetate 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

206 genes differentially expressed following the CRCGN011_HEPG2_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.5236
ASCC3 activating signal cointegrator 1 complex subunit 3 4.97125
HMOX1 heme oxygenase 1 4.7895
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.13935
CXCL2 chemokine (C-X-C motif) ligand 2 4.0202
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.92175
TESK1 testis-specific kinase 1 3.62075
CYCS cytochrome c, somatic 3.50725
TRPV2 transient receptor potential cation channel, subfamily V, member 2 3.01255
UBQLN2 ubiquilin 2 2.97385
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.88325
EVL Enah/Vasp-like 2.86815
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.76755
WASF3 WAS protein family, member 3 2.75575
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.7378
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.7052
FCHO1 FCH domain only 1 2.6854
TRH thyrotropin-releasing hormone 2.6594
GRB10 growth factor receptor-bound protein 10 2.63522
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.62
STAP2 signal transducing adaptor family member 2 2.5905
SMNDC1 survival motor neuron domain containing 1 2.587
GADD45G growth arrest and DNA-damage-inducible, gamma 2.55395
PECR peroxisomal trans-2-enoyl-CoA reductase 2.5516
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.5279
C2CD2 C2 calcium-dependent domain containing 2 2.47345
BLMH bleomycin hydrolase 2.4654
CCL2 chemokine (C-C motif) ligand 2 2.4492
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.43675
PRKCQ protein kinase C, theta 2.4265
TSSC4 tumor suppressing subtransferable candidate 4 2.42015
EAPP E2F-associated phosphoprotein 2.3916
KIF1B kinesin family member 1B 2.38495
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.383
H2BC21 H2B clustered histone 21 2.3785
ZDHHC6 zinc finger, DHHC-type containing 6 2.3626
THOC1 THO complex 1 2.3391
MYLK myosin light chain kinase 2.3027
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.29585
MAMLD1 mastermind-like domain containing 1 2.2902
EXTL2 exostosin-like glycosyltransferase 2 2.28115
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.2758
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.27295
SKIC2 SKI2 subunit of superkiller complex 2.265
CKS1B CDC28 protein kinase regulatory subunit 1B 2.26025
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.2572
FYN FYN proto-oncogene, Src family tyrosine kinase 2.25133
MANF mesencephalic astrocyte-derived neurotrophic factor 2.2504
MAGEH1 melanoma antigen family H1 2.23595
CCP110 centriolar coiled coil protein 110kDa 2.2306
FKBPL FK506 binding protein like 2.22775
HLA-DOB major histocompatibility complex, class II, DO beta 2.2267
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.20865
DPY19L4 dpy-19-like 4 (C. elegans) 2.1696
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 2.168
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.15525
OTUD3 OTU deubiquitinase 3 2.1504
GOLM1 golgi membrane protein 1 2.14545
NTSR1 neurotensin receptor 1 (high affinity) 2.13565
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.1282
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.12665
ARMCX2 armadillo repeat containing, X-linked 2 2.11945
LCMT1 leucine carboxyl methyltransferase 1 2.10285
LAGE3 L antigen family, member 3 2.0832
SIL1 SIL1 nucleotide exchange factor 2.08265
TGM5 transglutaminase 5 2.06645
NXT1 nuclear transport factor 2-like export factor 1 2.05925
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 2.05597
MRPL11 mitochondrial ribosomal protein L11 2.05545
PKD2L1 polycystic kidney disease 2-like 1 2.0543
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.0528
ABHD4 abhydrolase domain containing 4 2.0439
STX4 syntaxin 4 2.0358
MRPL48 mitochondrial ribosomal protein L48 2.02275
B4GAT1 beta-1,4-glucuronyltransferase 1 2.01425
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.0139
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.01235
CA9 carbonic anhydrase IX 2.0091
CHODL chondrolectin 2.006
UNC13B unc-13 homolog B (C. elegans) 2.005
TREM1 triggering receptor expressed on myeloid cells 1 2.0046

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.3667
FGFR4 fibroblast growth factor receptor 4 -8.31853
GNAS GNAS complex locus -7.45979
SLC35F2 solute carrier family 35, member F2 -7.2616
HEATR1 HEAT repeat containing 1 -6.46473
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.5478
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.52105
UBE3C ubiquitin protein ligase E3C -5.00835
CDC25B cell division cycle 25B -4.90405
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8192
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.81815
MAP7 microtubule-associated protein 7 -4.65183
ARID5B AT rich interactive domain 5B (MRF1-like) -4.6278
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.46875
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.44335
TBC1D31 TBC1 domain family, member 31 -4.38605
CCDC86 coiled-coil domain containing 86 -4.18245
GRN granulin -4.06305
GRWD1 glutamate-rich WD repeat containing 1 -4.01735
KIF14 kinesin family member 14 -3.90125
HMG20B high mobility group 20B -3.73948
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.6022
DCK deoxycytidine kinase -3.50755
ACAA1 acetyl-CoA acyltransferase 1 -3.22092
TRAP1 TNF receptor-associated protein 1 -3.09055
IPO13 importin 13 -3.0653
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.93265
FTO fat mass and obesity associated -2.9011
IER3 immediate early response 3 -2.8319
ZNHIT6 zinc finger, HIT-type containing 6 -2.80925
TBCE tubulin folding cofactor E -2.805
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.742
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.71855
CHIC2 cysteine-rich hydrophobic domain 2 -2.68185
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.6507
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.63265
MYD88 myeloid differentiation primary response 88 -2.62165
COPS7A COP9 signalosome subunit 7A -2.60495
ARID4B AT rich interactive domain 4B (RBP1-like) -2.5963
WDR76 WD repeat domain 76 -2.5611
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.56075
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.5589
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -2.53935
TSPAN6 tetraspanin 6 -2.52635
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.526
ZNF223 zinc finger protein 223 -2.51525
PPA1 pyrophosphatase (inorganic) 1 -2.4822
ASB9 ankyrin repeat and SOCS box containing 9 -2.45675
MBTD1 mbt domain containing 1 -2.439
RBM34 RNA binding motif protein 34 -2.42775
GPR176 G protein-coupled receptor 176 -2.4108
LPAR4 lysophosphatidic acid receptor 4 -2.3964
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.34795
LPIN1 lipin 1 -2.3371
BCAP31 B-cell receptor-associated protein 31 -2.32535
VEZT vezatin, adherens junctions transmembrane protein -2.31765
DAZL deleted in azoospermia-like -2.31605
ART3 ADP-ribosyltransferase 3 -2.3151
IRAK1 interleukin-1 receptor-associated kinase 1 -2.30415
RGS19 regulator of G-protein signaling 19 -2.29695
ITGB1BP1 integrin beta 1 binding protein 1 -2.2967
HESX1 HESX homeobox 1 -2.2959
ZNF480 zinc finger protein 480 -2.28195
GDF15 growth differentiation factor 15 -2.24725
MICB MHC class I polypeptide-related sequence B -2.2456
RAVER2 ribonucleoprotein, PTB-binding 2 -2.2408
ADGRE3 adhesion G protein-coupled receptor E3 -2.2385
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.2357
CHEK1 checkpoint kinase 1 -2.22732
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.2198
SNX11 sorting nexin 11 -2.2026
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.18605
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.18425
GSTM2 glutathione S-transferase mu 2 (muscle) -2.17177
REEP5 receptor accessory protein 5 -2.1702
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.1698
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.1589
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.1523
POLR1F RNA polymerase I subunit F -2.15075
ISOC2 isochorismatase domain containing 2 -2.1505
FOXN2 forkhead box N2 -2.1406
ERCC3 excision repair cross-complementation group 3 -2.13525
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.1294
C1RL complement component 1, r subcomponent-like -2.12485
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -2.1225
TEP1 telomerase-associated protein 1 -2.1178
SPRYD7 SPRY domain containing 7 -2.11465
TAS2R10 taste receptor, type 2, member 10 -2.10595
PLXNB3 plexin B3 -2.09605
TTC27 tetratricopeptide repeat domain 27 -2.08885
TTBK2 tau tubulin kinase 2 -2.0849
FOXE3 forkhead box E3 -2.0835
TRIM37 tripartite motif containing 37 -2.0823
PREB prolactin regulatory element binding -2.0822
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -2.07678
KRT86 keratin 86, type II -2.07485
CCDC6 coiled-coil domain containing 6 -2.0697
ZNF749 zinc finger protein 749 -2.0665
COQ6 coenzyme Q6 monooxygenase -2.06575
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.06275
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.0626
PNLIP pancreatic lipase -2.05455
SPOP speckle-type POZ protein -2.05152
MSH4 mutS homolog 4 -2.04835
NGRN neugrin, neurite outgrowth associated -2.03925
TTC12 tetratricopeptide repeat domain 12 -2.03815
MIS18BP1 MIS18 binding protein 1 -2.0381
ADGB androglobin -2.0373
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -2.0355
STAU1 staufen double-stranded RNA binding protein 1 -2.03542
TM4SF1 transmembrane 4 L six family member 1 -2.03539
TMEM115 transmembrane protein 115 -2.0313
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.0284
FKBP14 FK506 binding protein 14, 22 kDa -2.0283
UBE4A ubiquitination factor E4A -2.0184
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.01705
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.0135
SPANXB1 SPANX family, member B1 -2.01125
CST5 cystatin D -2.0111
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.0109
KNTC1 kinetochore associated 1 -2.00985
ZBTB33 zinc finger and BTB domain containing 33 -2.00885
MTRF1 mitochondrial translational release factor 1 -2.00665
R3HCC1L R3H domain and coiled-coil containing 1-like -2.00465