CRCGN011_HEPG2_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibutyltin diacetate 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN011_HEPG2_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 8.96185
ABHD6 abhydrolase domain containing 6 7.432
CHMP6 charged multivesicular body protein 6 5.274
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.20265
UBQLN2 ubiquilin 2 5.0415
PNKP polynucleotide kinase 3'-phosphatase 4.8851
NOTCH1 notch 1 4.616
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 4.4324
C2CD2 C2 calcium-dependent domain containing 2 4.34465
E2F2 E2F transcription factor 2 4.0639
CXCR4 chemokine (C-X-C motif) receptor 4 3.86768
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.68935
HOXA10 homeobox A10 3.66727
FZD7 frizzled class receptor 7 3.18038
MOK MOK protein kinase 2.94175
JADE2 jade family PHD finger 2 2.93535
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.80838
GPATCH8 G patch domain containing 8 2.7122
CYCS cytochrome c, somatic 2.6877
FGF6 fibroblast growth factor 6 2.5835
VWA7 von Willebrand factor A domain containing 7 2.5759
LIPG lipase, endothelial 2.5667
GYG2 glycogenin 2 2.54862
GPC1 glypican 1 2.53122
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.49883
GPER1 G protein-coupled estrogen receptor 1 2.49535
ACAA2 acetyl-CoA acyltransferase 2 2.46283
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.4234
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.40295
CD244 CD244 molecule, natural killer cell receptor 2B4 2.40265
NYNRIN NYN domain and retroviral integrase containing 2.37735
TMEM135 transmembrane protein 135 2.3575
CLCN2 chloride channel, voltage-sensitive 2 2.353
EVL Enah/Vasp-like 2.3106
TSPYL2 TSPY-like 2 2.2785
ACACB acetyl-CoA carboxylase beta 2.22648
MEP1B meprin A, beta 2.2075
HMOX1 heme oxygenase 1 2.196
ADRA1D adrenoceptor alpha 1D 2.1893
TRMT9B tRNA methyltransferase 9B (putative) 2.1869
EPHA3 EPH receptor A3 2.17028
LAMC3 laminin, gamma 3 2.1663
PLSCR3 phospholipid scramblase 3 2.1616
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.15375
SSUH2 ssu-2 homolog (C. elegans) 2.15225
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.13345
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.13306
GGT5 gamma-glutamyltransferase 5 2.13045
NELL2 NEL-like 2 (chicken) 2.1198
AKR1D1 aldo-keto reductase family 1, member D1 2.1001
GUCA1B guanylate cyclase activator 1B (retina) 2.09785
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.0949
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.09005
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.0897
DCHS2 dachsous cadherin-related 2 2.0805
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.06752
SLC66A3 solute carrier family 66 member 3 2.061
FZD4 frizzled class receptor 4 2.05785
NKX2-2 NK2 homeobox 2 2.05295
JAM3 junctional adhesion molecule 3 2.0494
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.0429
ZIM2 zinc finger, imprinted 2 2.04035
GPR4 G protein-coupled receptor 4 2.03367
ADRB3 adrenoceptor beta 3 2.03245
PAX3 paired box 3 2.01837
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.01715
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.01155
DCC DCC netrin 1 receptor 2.0107

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.88275
CCNB2 cyclin B2 -7.6655
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.7462
COG2 component of oligomeric golgi complex 2 -5.6432
DNM1L dynamin 1-like -5.07895
CCNB1 cyclin B1 -5.0058
LDHD lactate dehydrogenase D -4.93835
TRIB3 tribbles pseudokinase 3 -4.9053
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.34855
SNX11 sorting nexin 11 -2.87538
TLCD3A TLC domain containing 3A -2.7293
SLC35F2 solute carrier family 35, member F2 -2.7122
IPO13 importin 13 -2.5193
CYREN cell cycle regulator of NHEJ -2.3571
TSC22D1 TSC22 domain family, member 1 -2.35475
GPN2 GPN-loop GTPase 2 -2.19915
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.1983
TRAPPC6A trafficking protein particle complex 6A -2.1837
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.179
TOR1A torsin family 1, member A (torsin A) -2.08162
PPP1R3C protein phosphatase 1, regulatory subunit 3C -2.0192