CRCGN011_HEPG2_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN011_HEPG2_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCNA1 cyclin A1 6.02045
CYCS cytochrome c, somatic 6.0111
CARMIL1 capping protein regulator and myosin 1 linker 1 5.33675
MYLK myosin light chain kinase 5.27095
STIMATE STIM activating enhancer 4.9645
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9484
TLR4 toll-like receptor 4 4.89395
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.86675
CIAO3 cytosolic iron-sulfur assembly component 3 4.81735
PLS1 plastin 1 4.802
C2CD2 C2 calcium-dependent domain containing 2 4.74915
GSTZ1 glutathione S-transferase zeta 1 4.7237
UBQLN2 ubiquilin 2 4.7179
SQOR sulfide quinone oxidoreductase 4.67225
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.7205
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.36275
MEST mesoderm specific transcript 3.31565
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.27905
ADGRE5 adhesion G protein-coupled receptor E5 2.70995
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.47795
ZNF12 zinc finger protein 12 2.42255
PSEN1 presenilin 1 2.41033
ARPP19 cAMP-regulated phosphoprotein, 19kDa 2.34
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.32345
CCDC198 coiled-coil domain containing 198 2.30385
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.23063
CHN1 chimerin 1 2.14225
IFI6 interferon, alpha-inducible protein 6 2.13505
ZFYVE21 zinc finger, FYVE domain containing 21 2.12475
BAD BCL2-associated agonist of cell death 2.11347
KLHL9 kelch-like family member 9 2.0853
CFP complement factor properdin 2.08385
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.06198
MRPL4 mitochondrial ribosomal protein L4 2.02315

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.5763
CCNB2 cyclin B2 -7.43425
KDM3A lysine (K)-specific demethylase 3A -4.85205
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6574
VAT1 vesicle amine transport 1 -4.5693
HMG20B high mobility group 20B -3.96475
MAPK13 mitogen-activated protein kinase 13 -3.62073
GNAS GNAS complex locus -3.40216
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.8261
HLA-DMA major histocompatibility complex, class II, DM alpha -2.6237
NRIP1 nuclear receptor interacting protein 1 -2.52397
TCEAL4 transcription elongation factor A (SII)-like 4 -2.496
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.452
FBXO7 F-box protein 7 -2.4276
TLCD3A TLC domain containing 3A -2.355
PANK2 pantothenate kinase 2 -2.26165
BAHD1 bromo adjacent homology domain containing 1 -2.24045
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.2063
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.19035
USP6NL USP6 N-terminal like -2.12435
WDR11 WD repeat domain 11 -2.10555
TALDO1 transaldolase 1 -2.0046