CRCGN011_HEPG2_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN011_HEPG2_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPATCH8 G patch domain containing 8 5.93733
MAMLD1 mastermind-like domain containing 1 5.1919
UBQLN2 ubiquilin 2 5.03405
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.8422
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7251
CBR3 carbonyl reductase 3 4.35145
SNAP25 synaptosomal-associated protein, 25kDa 4.19933
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.12635
GPER1 G protein-coupled estrogen receptor 1 3.79745
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.69075
CEP57 centrosomal protein 57kDa 3.65763
CCL2 chemokine (C-C motif) ligand 2 3.63785
EVL Enah/Vasp-like 3.60075
NMU neuromedin U 3.59015
EPN2 epsin 2 3.4325
PRR15L proline rich 15-like 3.40665
GATA3 GATA binding protein 3 3.27257
SSBP2 single-stranded DNA binding protein 2 2.76802
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.5283
CHEK2 checkpoint kinase 2 2.48185
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.3474
RPS9 ribosomal protein S9 2.27303
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.26455
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 2.2516
ITGA10 integrin, alpha 10 2.2258
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.2249
RPL18 ribosomal protein L18 2.1882
PKN1 protein kinase N1 2.17847
TRIM13 tripartite motif containing 13 2.14335
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.12102
FCHO1 FCH domain only 1 2.118
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.11665
EDN1 endothelin 1 2.1089
COPS7B COP9 signalosome subunit 7B 2.094
XYLT1 xylosyltransferase I 2.09395
BPHL biphenyl hydrolase-like (serine hydrolase) 2.09385
RPL21 ribosomal protein L21 2.07945
RPL8 ribosomal protein L8 2.0686
RPL19 ribosomal protein L19 2.0567
CORO1A coronin, actin binding protein, 1A 2.04825
EIF3H eukaryotic translation initiation factor 3, subunit H 2.04245
PMM2 phosphomannomutase 2 2.0228

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.26785
TRIB3 tribbles pseudokinase 3 -5.40695
KDM3A lysine (K)-specific demethylase 3A -5.34685
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.0963
PCNA proliferating cell nuclear antigen -4.7455
THAP11 THAP domain containing 11 -4.65115
LDHD lactate dehydrogenase D -4.64385
DNM1L dynamin 1-like -4.607
FGFR4 fibroblast growth factor receptor 4 -3.98828
CCNB2 cyclin B2 -3.78265
SLC35F2 solute carrier family 35, member F2 -3.7272
NGRN neugrin, neurite outgrowth associated -3.33935
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.06405
GIPC1 GIPC PDZ domain containing family, member 1 -2.83235
SNX11 sorting nexin 11 -2.70727
MAPK13 mitogen-activated protein kinase 13 -2.39048
ITGB1BP1 integrin beta 1 binding protein 1 -2.34635
CDC25B cell division cycle 25B -2.3098
RNF167 ring finger protein 167 -2.2933
HLA-DMA major histocompatibility complex, class II, DM alpha -2.2801
HMG20B high mobility group 20B -2.23952
PDZD2 PDZ domain containing 2 -2.1686
TMEM106C transmembrane protein 106C -2.1464
AKTIP AKT interacting protein -2.1082
MAGEC1 melanoma antigen family C1 -2.053
HS1BP3 HCLS1 binding protein 3 -2.0498
SCCPDH saccharopine dehydrogenase (putative) -2.03955
PLPP1 phospholipid phosphatase 1 -2.00925