CRCGN011_HEPG2_24H:E16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN011_HEPG2_24H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.03635
NMU neuromedin U 5.7783
MYLK myosin light chain kinase 5.32905
GPATCH8 G patch domain containing 8 5.32275
SNAP25 synaptosomal-associated protein, 25kDa 5.3002
ADRB2 adrenoceptor beta 2, surface 5.24025
E2F2 E2F transcription factor 2 5.2356
CSK c-src tyrosine kinase 4.91515
LAGE3 L antigen family, member 3 4.88255
MSRA methionine sulfoxide reductase A 4.83135
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.7338
CARMIL1 capping protein regulator and myosin 1 linker 1 4.5139
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.4831
MAMLD1 mastermind-like domain containing 1 3.90435
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.76087
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.65675
ABHD6 abhydrolase domain containing 6 3.5313
IQGAP1 IQ motif containing GTPase activating protein 1 3.0475
ZNF589 zinc finger protein 589 2.89215
COL11A1 collagen, type XI, alpha 1 2.73633
RAB33A RAB33A, member RAS oncogene family 2.67775
NEUROD6 neuronal differentiation 6 2.65325
PDLIM1 PDZ and LIM domain 1 2.6477
TIAM1 T-cell lymphoma invasion and metastasis 1 2.62995
PTPRM protein tyrosine phosphatase, receptor type, M 2.62575
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.61572
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.4455
HLA-DRA major histocompatibility complex, class II, DR alpha 2.4133
RNF167 ring finger protein 167 2.4025
DYNLT3 dynein, light chain, Tctex-type 3 2.38985
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.36715
FRZB frizzled-related protein 2.3606
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.358
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.335
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.32815
BIRC2 baculoviral IAP repeat containing 2 2.28105
ST18 suppression of tumorigenicity 18, zinc finger 2.2229
GATA2 GATA binding protein 2 2.17435
GPR19 G protein-coupled receptor 19 2.15975
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.1556
TEX15 testis expressed 15 2.13945
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.1362
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 2.1032
MYOZ1 myozenin 1 2.07155
GDF3 growth differentiation factor 3 2.05255
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.05023
SINHCAF SIN3-HDAC complex associated factor 2.03905
NOSIP nitric oxide synthase interacting protein 2.03555
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 2.03115
LOC122526780 uncharacterized LOC122526780 2.02905
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.02275

decreased expression

Symbol Name Standardized Value
DUSP6 dual specificity phosphatase 6 -5.04245
GDF15 growth differentiation factor 15 -5.0
CCNB1 cyclin B1 -4.695
MRPS2 mitochondrial ribosomal protein S2 -4.6562
MAP7 microtubule-associated protein 7 -4.45317
SCAND1 SCAN domain containing 1 -4.4272
RFC2 replication factor C (activator 1) 2, 40kDa -4.21992
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.12575
OXA1L oxidase (cytochrome c) assembly 1-like -3.65495
ADI1 acireductone dioxygenase 1 -3.373
HEATR1 HEAT repeat containing 1 -3.3606
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.31785
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.281
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.94925
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.8481
CD58 CD58 molecule -2.74393
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.6079
CDC25B cell division cycle 25B -2.4989
MAPK13 mitogen-activated protein kinase 13 -2.46793
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.44534
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.44425
EFNA1 ephrin-A1 -2.42455
EVA1B eva-1 homolog B (C. elegans) -2.39185
RAB8A RAB8A, member RAS oncogene family -2.194
DENND10 DENN domain containing 10 -2.193
CCNB2 cyclin B2 -2.15165
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.15105
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.14255
ACAA1 acetyl-CoA acyltransferase 1 -2.0999
C8A complement component 8, alpha polypeptide -2.03845
LRP3 low density lipoprotein receptor-related protein 3 -2.0266
FAM32A family with sequence similarity 32, member A -2.02365