CRCGN011_HEPG2_24H:E18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrazine sulfate 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN011_HEPG2_24H:E18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.1231
NFIL3 nuclear factor, interleukin 3 regulated 5.36035
CXCL2 chemokine (C-X-C motif) ligand 2 5.33725
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.94061
PPARG peroxisome proliferator-activated receptor gamma 4.8484
E2F2 E2F transcription factor 2 4.81145
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.737
STIMATE STIM activating enhancer 4.60065
PEX11A peroxisomal biogenesis factor 11 alpha 3.94685
SSBP2 single-stranded DNA binding protein 2 3.64947
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.30133
NMU neuromedin U 2.9635
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.91385
GPER1 G protein-coupled estrogen receptor 1 2.75358
SPANXB1 SPANX family, member B1 2.6475
PAGE1 P antigen family, member 1 (prostate associated) 2.64065
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.5594
TMOD1 tropomodulin 1 2.51135
CNGA3 cyclic nucleotide gated channel alpha 3 2.48855
CETN3 centrin, EF-hand protein, 3 2.4671
LOC124908558 X antigen family member 1-like 2.4516
CMA1 chymase 1, mast cell 2.42405
BMPR1A bone morphogenetic protein receptor, type IA 2.386
SAGE1 sarcoma antigen 1 2.37725
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.32035
COQ8A coenzyme Q8A 2.3105
KPTN kaptin (actin binding protein) 2.30925
MYH13 myosin, heavy chain 13, skeletal muscle 2.29575
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.2612
BIRC2 baculoviral IAP repeat containing 2 2.2502
ZNF37A zinc finger protein 37A 2.24415
GAGE1 G antigen 1 2.2412
MBNL2 muscleblind-like splicing regulator 2 2.2036
NMUR1 neuromedin U receptor 1 2.20275
TNIP1 TNFAIP3 interacting protein 1 2.12335
MEST mesoderm specific transcript 2.1233
PIH1D1 PIH1 domain containing 1 2.11605
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.11515
FAM53C family with sequence similarity 53, member C 2.1046
PRELID3B PRELI domain containing 3B 2.10095
MAGEA6 melanoma antigen family A6 2.09615
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.0956
NUP133 nucleoporin 133kDa 2.0875
MELK maternal embryonic leucine zipper kinase 2.0733
SGCE sarcoglycan, epsilon 2.0678
WDTC1 WD and tetratricopeptide repeats 1 2.06652
TNIP2 TNFAIP3 interacting protein 2 2.04662
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 2.03475
SSX1 synovial sarcoma, X breakpoint 1 2.0342
PPP4C protein phosphatase 4, catalytic subunit 2.0268
ZXDB zinc finger, X-linked, duplicated B 2.01465
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.00445
HOMER1 homer scaffolding protein 1 2.00165
TRIL TLR4 interactor with leucine-rich repeats 2.00082

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CHMP4B charged multivesicular body protein 4B -8.90637
CCNB2 cyclin B2 -6.7897
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.38565
NT5DC2 5'-nucleotidase domain containing 2 -5.1188
MRPS2 mitochondrial ribosomal protein S2 -4.94385
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.8039
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.699
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.63855
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.0569
OXA1L oxidase (cytochrome c) assembly 1-like -3.83195
PCNA proliferating cell nuclear antigen -3.42975
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.30942
VDAC1 voltage-dependent anion channel 1 -3.0213
CD58 CD58 molecule -2.66128
RNF167 ring finger protein 167 -2.64625
SLC35F2 solute carrier family 35, member F2 -2.6419
CCNL2 cyclin L2 -2.59635
EMC9 ER membrane protein complex subunit 9 -2.5676
ACAA1 acetyl-CoA acyltransferase 1 -2.55058
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.53757
IDO1 indoleamine 2,3-dioxygenase 1 -2.52555
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.3645
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.29215
CAMTA2 calmodulin binding transcription activator 2 -2.20105
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.1772
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.15585
SGSH N-sulfoglucosamine sulfohydrolase -2.1487
WDR73 WD repeat domain 73 -2.1171
EIF5 eukaryotic translation initiation factor 5 -2.10653
ZNHIT3 zinc finger, HIT-type containing 3 -2.0933
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.09168
TM9SF1 transmembrane 9 superfamily member 1 -2.05573
SMYD2 SET and MYND domain containing 2 -2.0543
ST20-MTHFS ST20-MTHFS readthrough -2.01525
DDTL D-dopachrome tautomerase-like -2.0071