CRCGN011_HEPG2_24H:E19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethylamine 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

77 genes differentially expressed following the CRCGN011_HEPG2_24H:E19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 9.14005
MYLK myosin light chain kinase 5.4512
EVL Enah/Vasp-like 5.24315
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8284
ADRB2 adrenoceptor beta 2, surface 4.7605
CHN1 chimerin 1 4.4175
MOK MOK protein kinase 4.308
ABHD6 abhydrolase domain containing 6 4.25318
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.605
MAP7 microtubule-associated protein 7 3.561
CYCS cytochrome c, somatic 3.4511
WDTC1 WD and tetratricopeptide repeats 1 3.22328
SOCS2 suppressor of cytokine signaling 2 3.21555
VGLL4 vestigial-like family member 4 2.93243
PRR15L proline rich 15-like 2.65225
MAST2 microtubule associated serine/threonine kinase 2 2.5867
DIPK1A divergent protein kinase domain 1A 2.52715
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.5138
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.4908
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.47125
RSRC1 arginine/serine-rich coiled-coil 1 2.3404
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.30533
ZNF273 zinc finger protein 273 2.2734
FPGS folylpolyglutamate synthase 2.26765
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.25145
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.1972
GPER1 G protein-coupled estrogen receptor 1 2.1968
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.19198
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.1887
KLHL9 kelch-like family member 9 2.16293
TREM1 triggering receptor expressed on myeloid cells 1 2.13135
UNG uracil-DNA glycosylase 2.1067
ADAT1 adenosine deaminase, tRNA-specific 1 2.07835
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.06185
PRDX1 peroxiredoxin 1 2.052
KAT6A K(lysine) acetyltransferase 6A 2.05035
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.04305
GPSM3 G-protein signaling modulator 3 2.02063
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0201
DHCR7 7-dehydrocholesterol reductase 2.01093
ECT2 epithelial cell transforming 2 2.0084
TRAPPC14 trafficking protein particle complex subunit 14 2.00515
SLC38A6 solute carrier family 38, member 6 2.00345

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -5.6359
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.15795
TM9SF3 transmembrane 9 superfamily member 3 -5.006
LDHD lactate dehydrogenase D -4.84845
THAP11 THAP domain containing 11 -4.82845
CCDC86 coiled-coil domain containing 86 -4.70435
PLK1 polo-like kinase 1 -4.691
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.1125
LOC124907782 dual specificity protein phosphatase 22 -4.06335
GNAS GNAS complex locus -3.60721
HMG20B high mobility group 20B -3.53115
GDF15 growth differentiation factor 15 -3.5308
NRIP1 nuclear receptor interacting protein 1 -3.4184
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.39055
YME1L1 YME1-like 1 ATPase -3.30257
CCNB2 cyclin B2 -3.1959
GRN granulin -3.1069
ADI1 acireductone dioxygenase 1 -3.10105
RPS5 ribosomal protein S5 -2.95175
CD58 CD58 molecule -2.82802
CDC25B cell division cycle 25B -2.79855
MVP major vault protein -2.6914
RHEX regulator of hemoglobinization and erythroid cell expansion -2.42737
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.3684
C5 complement component 5 -2.3675
VDAC1 voltage-dependent anion channel 1 -2.34698
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.2763
UBFD1 ubiquitin family domain containing 1 -2.27265
SNX11 sorting nexin 11 -2.23207
HSPA4 heat shock 70kDa protein 4 -2.21396
NPDC1 neural proliferation, differentiation and control, 1 -2.14215
PTH2R parathyroid hormone 2 receptor -2.09825
WDR91 WD repeat domain 91 -2.0629
HMGN4 high mobility group nucleosomal binding domain 4 -2.0361