CRCGN011_HEPG2_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethylamine 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN011_HEPG2_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
GFOD1 glucose-fructose oxidoreductase domain containing 1 5.21095
MYLK myosin light chain kinase 5.204
MCOLN1 mucolipin 1 5.1925
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.1323
LAGE3 L antigen family, member 3 4.84895
CARMIL1 capping protein regulator and myosin 1 linker 1 4.74675
TAC4 tachykinin 4 (hemokinin) 4.60015
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.59165
NMU neuromedin U 3.8431
SSBP2 single-stranded DNA binding protein 2 3.53313
BLMH bleomycin hydrolase 3.47375
ZNF589 zinc finger protein 589 3.04477
DENND2D DENN/MADD domain containing 2D 3.01655
DOK7 docking protein 7 2.71125
CEP57 centrosomal protein 57kDa 2.575
HPS4 Hermansky-Pudlak syndrome 4 2.5642
SKIC8 SKI8 subunit of superkiller complex 2.54247
FGF4 fibroblast growth factor 4 2.46275
EPHA3 EPH receptor A3 2.39583
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.3333
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 2.3172
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.3023
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.29475
BTK Bruton agammaglobulinemia tyrosine kinase 2.29245
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.27065
TLR4 toll-like receptor 4 2.26045
TRAK2 trafficking protein, kinesin binding 2 2.2461
TRAPPC14 trafficking protein particle complex subunit 14 2.24045
TCL1B T-cell leukemia/lymphoma 1B 2.2257
DOCK2 dedicator of cytokinesis 2 2.21295
NALF1 NALCN channel auxiliary factor 1 2.1887
BMP4 bone morphogenetic protein 4 2.16705
CRMP1 collapsin response mediator protein 1 2.16315
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.15025
PCDHGA5 protocadherin gamma subfamily A, 5 2.1466
HTRA2 HtrA serine peptidase 2 2.1161
RMDN1 regulator of microtubule dynamics 1 2.07735
FHIT fragile histidine triad 2.062
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.04915
RHOT2 ras homolog family member T2 2.04572
BCR breakpoint cluster region 2.0324
CTC1 CTS telomere maintenance complex component 1 2.03125
DPPA4 developmental pluripotency associated 4 2.01605
F13A1 coagulation factor XIII, A1 polypeptide 2.0154
ECSIT ECSIT signalling integrator 2.01455
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.00885
SFXN1 sideroflexin 1 2.0056
EVL Enah/Vasp-like 2.00135

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.4478
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.3331
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9241
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.83605
ISOC1 isochorismatase domain containing 1 -4.7809
ADI1 acireductone dioxygenase 1 -4.7385
PLK1 polo-like kinase 1 -4.4813
CCNB2 cyclin B2 -4.167
ITGB1BP1 integrin beta 1 binding protein 1 -3.8113
PCNA proliferating cell nuclear antigen -3.6761
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.59445
CD320 CD320 molecule -3.5839
GNAS GNAS complex locus -3.46836
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.17512
PTPRK protein tyrosine phosphatase, receptor type, K -2.90975
RFC2 replication factor C (activator 1) 2, 40kDa -2.86523
PRPF4 pre-mRNA processing factor 4 -2.7451
STAT1 signal transducer and activator of transcription 1, 91kDa -2.65838
ELF4 E74-like factor 4 (ets domain transcription factor) -2.62367
TLCD3A TLC domain containing 3A -2.6149
TNS3 tensin 3 -2.5312
TBKBP1 TBK1 binding protein 1 -2.44095
LGALS1 lectin, galactoside-binding, soluble, 1 -2.34805
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -2.27187
SPOUT1 SPOUT domain containing methyltransferase 1 -2.2414
HRAS Harvey rat sarcoma viral oncogene homolog -2.23545
PTDSS2 phosphatidylserine synthase 2 -2.21025
S100A4 S100 calcium binding protein A4 -2.20575
DBR1 debranching RNA lariats 1 -2.2016
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.1595
MXRA7 matrix-remodelling associated 7 -2.0525
CYBA cytochrome b-245, alpha polypeptide -2.0476
COPB1 coatomer protein complex, subunit beta 1 -2.03108