| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-nitrosodiethylamine 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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71 genes differentially expressed following the CRCGN011_HEPG2_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL39L | ribosomal protein L39-like | 5.1247 |
| MOK | MOK protein kinase | 5.09125 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 4.9855 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.8645 |
| NOTCH1 | notch 1 | 4.8532 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.73175 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.59165 |
| E2F2 | E2F transcription factor 2 | 4.5044 |
| CHN1 | chimerin 1 | 4.0252 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.94115 |
| DENND2D | DENN/MADD domain containing 2D | 3.62545 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.4408 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.43613 |
| LCN2 | lipocalin 2 | 3.247 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.0159 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.942 |
| JADE2 | jade family PHD finger 2 | 2.7362 |
| NMU | neuromedin U | 2.67565 |
| PUS7L | pseudouridylate synthase 7 homolog (S. cerevisiae)-like | 2.4413 |
| CYB561 | cytochrome b561 | 2.40204 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.3799 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.35843 |
| HSPA1A | heat shock 70kDa protein 1A | 2.35355 |
| BMP4 | bone morphogenetic protein 4 | 2.34855 |
| HDAC2 | histone deacetylase 2 | 2.334 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.28485 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 2.1976 |
| FPGS | folylpolyglutamate synthase | 2.19605 |
| BRCA1 | breast cancer 1, early onset | 2.08615 |
| NMI | N-myc (and STAT) interactor | 2.0723 |
| CHEK2 | checkpoint kinase 2 | 2.05895 |
| TMEM14B | transmembrane protein 14B | 2.01735 |
| TMEM100 | transmembrane protein 100 | 2.00485 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC86 | coiled-coil domain containing 86 | -5.35805 |
| LDHD | lactate dehydrogenase D | -5.3007 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -5.0 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.91645 |
| ZNF586 | zinc finger protein 586 | -4.87765 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.81045 |
| CD320 | CD320 molecule | -4.7915 |
| MAP7 | microtubule-associated protein 7 | -4.6754 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -4.5391 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.52145 |
| STAMBP | STAM binding protein | -3.806 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.70302 |
| GNAS | GNAS complex locus | -3.69558 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.6864 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -3.12338 |
| UBXN2B | UBX domain protein 2B | -2.87275 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.8388 |
| ZNF302 | zinc finger protein 302 | -2.71155 |
| RNF167 | ring finger protein 167 | -2.69535 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.68955 |
| YME1L1 | YME1-like 1 ATPase | -2.5668 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.50703 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -2.44305 |
| ZNF146 | zinc finger protein 146 | -2.4053 |
| SPAG4 | sperm associated antigen 4 | -2.31405 |
| CAPNS1 | calpain, small subunit 1 | -2.3037 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -2.25529 |
| WDR44 | WD repeat domain 44 | -2.24265 |
| TCN2 | transcobalamin II | -2.194 |
| ETNK1 | ethanolamine kinase 1 | -2.19368 |
| CSNK1E | casein kinase 1, epsilon | -2.18388 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -2.17185 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -2.15465 |
| PRPF4 | pre-mRNA processing factor 4 | -2.09207 |
| UCN | urocortin | -2.0705 |
| FRK | fyn-related Src family tyrosine kinase | -2.06595 |
| CHAMP1 | chromosome alignment maintaining phosphoprotein 1 | -2.02945 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -2.00585 |
