| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-nitrosodiethylamine 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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62 genes differentially expressed following the CRCGN011_HEPG2_24H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 10.0 |
| TAC4 | tachykinin 4 (hemokinin) | 5.4469 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5.12794 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 5.04315 |
| LOC122526780 | uncharacterized LOC122526780 | 4.5838 |
| LCN2 | lipocalin 2 | 4.2142 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 3.85795 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.81845 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.70665 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.66555 |
| EVL | Enah/Vasp-like | 3.6098 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.46907 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 3.29245 |
| PIH1D1 | PIH1 domain containing 1 | 3.199 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 3.11335 |
| CCNF | cyclin F | 2.74535 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.62595 |
| NMU | neuromedin U | 2.57585 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 2.48 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 2.41015 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.40515 |
| MELK | maternal embryonic leucine zipper kinase | 2.2441 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 2.1816 |
| TPSAB1 | tryptase alpha/beta 1 | 2.14654 |
| RBM38 | RNA binding motif protein 38 | 2.14565 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 2.10777 |
| IFI44L | interferon-induced protein 44-like | 2.07835 |
| PEF1 | penta-EF-hand domain containing 1 | 2.0616 |
| RIGI | RNA sensor RIG-I | 2.0337 |
| MX1 | MX dynamin-like GTPase 1 | 2.0269 |
| KLHL9 | kelch-like family member 9 | 2.0209 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 2.0146 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| ADI1 | acireductone dioxygenase 1 | -8.5679 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.43995 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -5.29695 |
| TLCD3A | TLC domain containing 3A | -5.07215 |
| LDHD | lactate dehydrogenase D | -4.9285 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.7706 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.26223 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.99867 |
| GNAS | GNAS complex locus | -3.48431 |
| PEG10 | paternally expressed 10 | -3.3824 |
| VDAC1 | voltage-dependent anion channel 1 | -3.3321 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.3017 |
| PRPF4 | pre-mRNA processing factor 4 | -2.8442 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.75385 |
| LOC128966601 | pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like | -2.3821 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.35617 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -2.27885 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.2633 |
| RNF167 | ring finger protein 167 | -2.21645 |
| RDH8 | retinol dehydrogenase 8 (all-trans) | -2.16175 |
| HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | -2.11465 |
| MAGEA9B | melanoma antigen family A9B | -2.1008 |
| TRIM66 | tripartite motif containing 66 | -2.0907 |
| CD320 | CD320 molecule | -2.08465 |
| APOLD1 | apolipoprotein L domain containing 1 | -2.07335 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -2.05675 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -2.04865 |
| DHCR7 | 7-dehydrocholesterol reductase | -2.04655 |
| ZNF586 | zinc finger protein 586 | -2.0178 |
