CRCGN011_HEPG2_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosodiethylamine 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN011_HEPG2_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MOK MOK protein kinase 5.4654
BACE2 beta-site APP-cleaving enzyme 2 5.17665
ADRB2 adrenoceptor beta 2, surface 5.1653
BZW2 basic leucine zipper and W2 domains 2 5.12025
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.01245
NOTCH1 notch 1 4.93435
ABHD4 abhydrolase domain containing 4 4.89945
INTS3 integrator complex subunit 3 4.82525
TBPL1 TBP-like 1 4.819
AMDHD2 amidohydrolase domain containing 2 4.7538
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.682
RRAGA Ras-related GTP binding A 4.53785
CCL2 chemokine (C-C motif) ligand 2 4.422
MAP7 microtubule-associated protein 7 3.66273
STIMATE STIM activating enhancer 3.31935
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.18325
TIAM1 T-cell lymphoma invasion and metastasis 1 3.15812
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.1419
EVL Enah/Vasp-like 3.07755
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.91825
JADE2 jade family PHD finger 2 2.8784
SFTPB surfactant protein B 2.8169
PLSCR3 phospholipid scramblase 3 2.80313
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.795
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.55335
ADAT1 adenosine deaminase, tRNA-specific 1 2.4841
GPER1 G protein-coupled estrogen receptor 1 2.42173
ADGRE5 adhesion G protein-coupled receptor E5 2.41935
RB1 retinoblastoma 1 2.3928
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 2.3327
TPD52L2 tumor protein D52-like 2 2.2896
ASF1A anti-silencing function 1A histone chaperone 2.27045
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.26725
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.2197
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.19523
ZNF589 zinc finger protein 589 2.18853
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.1627
HSPA1A heat shock 70kDa protein 1A 2.1602
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.14935
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.0624
DIPK1A divergent protein kinase domain 1A 2.04665
CCL19 chemokine (C-C motif) ligand 19 2.02125
ONECUT2 one cut homeobox 2 2.02085
SURF2 surfeit 2 2.01255
CYCS cytochrome c, somatic 2.0117
RASL10A RAS-like, family 10, member A 2.01095

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.45585
TLCD3A TLC domain containing 3A -5.4313
LDHD lactate dehydrogenase D -5.0532
ADI1 acireductone dioxygenase 1 -4.997
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.82755
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7725
PLK1 polo-like kinase 1 -4.76085
ZMIZ1 zinc finger, MIZ-type containing 1 -4.61275
UGDH UDP-glucose 6-dehydrogenase -4.3563
CDC20 cell division cycle 20 -4.2155
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.70685
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.5144
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.9101
SCAND1 SCAN domain containing 1 -2.8648
HEATR1 HEAT repeat containing 1 -2.84065
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.702
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.6689
IFRD2 interferon-related developmental regulator 2 -2.50585
WASHC4 WASH complex subunit 4 -2.38917
FOS FBJ murine osteosarcoma viral oncogene homolog -2.24005
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.22315
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.10615
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.07757
ZDHHC13 zinc finger, DHHC-type containing 13 -2.06135
AKAP8 A kinase (PRKA) anchor protein 8 -2.05165
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.0026