| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | dichloroacetic-acid 41.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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72 genes differentially expressed following the CRCGN011_HEPG2_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TLR4 | toll-like receptor 4 | 4.77305 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.4682 |
| MYLK | myosin light chain kinase | 4.43465 |
| HOXA10 | homeobox A10 | 4.3986 |
| CBR3 | carbonyl reductase 3 | 4.35145 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.13995 |
| LCN2 | lipocalin 2 | 4.0456 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.68995 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 3.53263 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.44208 |
| CDC45 | cell division cycle 45 | 3.4355 |
| EVL | Enah/Vasp-like | 3.37715 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.322 |
| KLHL9 | kelch-like family member 9 | 3.28688 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.21022 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.20267 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.1607 |
| GPATCH8 | G patch domain containing 8 | 2.87622 |
| SATB1 | SATB homeobox 1 | 2.8663 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.79055 |
| FERRY3 | FERRY endosomal RAB5 effector complex subunit 3 | 2.55325 |
| RAB31 | RAB31, member RAS oncogene family | 2.50255 |
| HMGA2 | high mobility group AT-hook 2 | 2.4064 |
| BAD | BCL2-associated agonist of cell death | 2.2926 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 2.2814 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.2638 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 2.259 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.16353 |
| PLS1 | plastin 1 | 2.1543 |
| PFDN1 | prefoldin subunit 1 | 2.1488 |
| CBX1 | chromobox homolog 1 | 2.14205 |
| TMEM258 | transmembrane protein 258 | 2.10395 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | 2.0993 |
| EPHA3 | EPH receptor A3 | 2.08645 |
| THAP12 | THAP domain containing 12 | 2.0708 |
| MTSS2 | MTSS I-BAR domain containing 2 | 2.06705 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -5.99985 |
| LDHD | lactate dehydrogenase D | -5.0532 |
| CDC20 | cell division cycle 20 | -5.0 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.95875 |
| LAP3 | leucine aminopeptidase 3 | -4.92495 |
| EIF5 | eukaryotic translation initiation factor 5 | -4.46594 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.20515 |
| ZNF274 | zinc finger protein 274 | -3.75875 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.52415 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.42835 |
| CIRBP | cold inducible RNA binding protein | -3.17965 |
| AURKB | aurora kinase B | -3.01245 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.88185 |
| IRAK4 | interleukin-1 receptor-associated kinase 4 | -2.8239 |
| PCNA | proliferating cell nuclear antigen | -2.8106 |
| RAI14 | retinoic acid induced 14 | -2.5168 |
| SPAG4 | sperm associated antigen 4 | -2.4706 |
| RNF167 | ring finger protein 167 | -2.34805 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.34305 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -2.34088 |
| PRRG2 | proline rich Gla (G-carboxyglutamic acid) 2 | -2.2199 |
| TRIM13 | tripartite motif containing 13 | -2.21615 |
| TRABD | TraB domain containing | -2.20805 |
| RHOH | ras homolog family member H | -2.19335 |
| ELOVL1 | ELOVL fatty acid elongase 1 | -2.18897 |
| DUSP5 | dual specificity phosphatase 5 | -2.1837 |
| STAT4 | signal transducer and activator of transcription 4 | -2.14695 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -2.1292 |
| RAP1B | RAP1B, member of RAS oncogene family | -2.0778 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -2.0634 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.05328 |
| BDKRB1 | bradykinin receptor B1 | -2.051 |
| DSE | dermatan sulfate epimerase | -2.0464 |
| DCAF15 | DDB1 and CUL4 associated factor 15 | -2.04418 |
| ZNF787 | zinc finger protein 787 | -2.01445 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | -2.01145 |
