| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | dichloroacetic-acid 20.5 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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71 genes differentially expressed following the CRCGN011_HEPG2_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DYNLT3 | dynein, light chain, Tctex-type 3 | 6.7924 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 5.0112 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8155 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.7746 |
| PLSCR1 | phospholipid scramblase 1 | 4.75677 |
| NOTCH1 | notch 1 | 4.4158 |
| ATP11B | ATPase, class VI, type 11B | 3.9212 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.75125 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.6723 |
| EPN2 | epsin 2 | 3.18782 |
| LCN2 | lipocalin 2 | 3.01395 |
| MSRA | methionine sulfoxide reductase A | 2.83095 |
| IFI27 | interferon, alpha-inducible protein 27 | 2.7051 |
| PSAT1 | phosphoserine aminotransferase 1 | 2.6644 |
| COQ8A | coenzyme Q8A | 2.55745 |
| CYCS | cytochrome c, somatic | 2.5436 |
| GLRX | glutaredoxin (thioltransferase) | 2.5283 |
| MX1 | MX dynamin-like GTPase 1 | 2.51455 |
| BAD | BCL2-associated agonist of cell death | 2.46863 |
| PMM2 | phosphomannomutase 2 | 2.4398 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | 2.3806 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 2.2775 |
| CDC45 | cell division cycle 45 | 2.2741 |
| FASTKD5 | FAST kinase domains 5 | 2.23195 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 2.15335 |
| BST2 | bone marrow stromal cell antigen 2 | 2.12695 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.1188 |
| PLSCR3 | phospholipid scramblase 3 | 2.10637 |
| NMU | neuromedin U | 2.1001 |
| MAPK6 | mitogen-activated protein kinase 6 | 2.01525 |
| PDZD8 | PDZ domain containing 8 | 2.0151 |
| NAMPT | nicotinamide phosphoribosyltransferase | 2.01013 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.0061 |
| IFI6 | interferon, alpha-inducible protein 6 | 2.0054 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| PCNA | proliferating cell nuclear antigen | -8.41805 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -5.10255 |
| TUBB6 | tubulin, beta 6 class V | -4.9609 |
| VAT1 | vesicle amine transport 1 | -4.75165 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -4.4519 |
| CHMP4B | charged multivesicular body protein 4B | -3.98742 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.88045 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.6749 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -3.52685 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.47635 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -3.3494 |
| GNAS | GNAS complex locus | -3.11364 |
| NVL | nuclear VCP-like | -2.869 |
| PRPF4 | pre-mRNA processing factor 4 | -2.81165 |
| SNX11 | sorting nexin 11 | -2.70173 |
| TBKBP1 | TBK1 binding protein 1 | -2.49125 |
| SNAI1 | snail family zinc finger 1 | -2.3754 |
| S100G | S100 calcium binding protein G | -2.3544 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -2.26525 |
| SNF8 | SNF8, ESCRT-II complex subunit | -2.26495 |
| FEV | FEV (ETS oncogene family) | -2.19315 |
| BPNT1 | 3'(2'), 5'-bisphosphate nucleotidase 1 | -2.18625 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -2.1402 |
| OPRPN | opiorphin prepropeptide | -2.1379 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -2.13485 |
| PTCD2 | pentatricopeptide repeat domain 2 | -2.1313 |
| OSBPL10 | oxysterol binding protein-like 10 | -2.0839 |
| CXXC4 | CXXC finger protein 4 | -2.08115 |
| HMHB1 | histocompatibility (minor) HB-1 | -2.0749 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | -2.04485 |
| PRAF2 | PRA1 domain family, member 2 | -2.04335 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.0412 |
| VCAM1 | vascular cell adhesion molecule 1 | -2.0201 |
| CD79B | CD79b molecule, immunoglobulin-associated beta | -2.00835 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -2.007 |
| CAB39 | calcium binding protein 39 | -2.0066 |
