CRCGN011_HEPG2_24H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dichloroacetic-acid 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN011_HEPG2_24H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 9.797
INTS3 integrator complex subunit 3 5.0243
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.00443
SYNE2 spectrin repeat containing, nuclear envelope 2 4.9825
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8015
CCL2 chemokine (C-C motif) ligand 2 4.67325
PNKP polynucleotide kinase 3'-phosphatase 4.67
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.4934
ADRB2 adrenoceptor beta 2, surface 4.49285
LCN2 lipocalin 2 4.0874
PRR15L proline rich 15-like 3.8028
DENND2D DENN/MADD domain containing 2D 3.76975
PFKL phosphofructokinase, liver 3.6477
CYCS cytochrome c, somatic 3.49685
RXYLT1 ribitol xylosyltransferase 1 3.45823
WDTC1 WD and tetratricopeptide repeats 1 3.08378
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.90185
CHN1 chimerin 1 2.80255
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.75585
HMHB1 histocompatibility (minor) HB-1 2.7536
CTC1 CTS telomere maintenance complex component 1 2.6762
ADAT1 adenosine deaminase, tRNA-specific 1 2.6441
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.62375
SNX7 sorting nexin 7 2.62205
NMU neuromedin U 2.575
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.56495
SIRT3 sirtuin 3 2.53715
S100G S100 calcium binding protein G 2.5323
CPNE7 copine VII 2.46865
GUCA1B guanylate cyclase activator 1B (retina) 2.3998
TLR3 toll-like receptor 3 2.3673
WNT16 wingless-type MMTV integration site family, member 16 2.36685
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.3492
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.34485
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.3422
ADAM10 ADAM metallopeptidase domain 10 2.34182
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.33435
TUBA3C tubulin, alpha 3c 2.30305
IL3RA interleukin 3 receptor, alpha (low affinity) 2.27975
CA7 carbonic anhydrase VII 2.25585
NXF3 nuclear RNA export factor 3 2.25025
ZBP1 Z-DNA binding protein 1 2.2479
TRIM5 tripartite motif containing 5 2.21025
PYCR3 pyrroline-5-carboxylate reductase 3 2.19875
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.19495
TSPAN14 tetraspanin 14 2.1927
CHPT1 choline phosphotransferase 1 2.17715
TMEM123 transmembrane protein 123 2.1768
BARD1 BRCA1 associated RING domain 1 2.17295
LGALS14 lectin, galactoside-binding, soluble, 14 2.16395
KIF17 kinesin family member 17 2.16275
BMX BMX non-receptor tyrosine kinase 2.14745
EPHA3 EPH receptor A3 2.13282
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.1298
PHF7 PHD finger protein 7 2.121
BIRC2 baculoviral IAP repeat containing 2 2.11925
DPP8 dipeptidyl-peptidase 8 2.113
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.1106
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.10415
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.0979
GJA8 gap junction protein, alpha 8, 50kDa 2.09195
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.09161
EI24 etoposide induced 2.4 2.0858
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.07685
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.07555
LOC102723996 ICOS ligand 2.07389
LY96 lymphocyte antigen 96 2.0717
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.07145
OXCT2 3-oxoacid CoA transferase 2 2.0706
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.06405
MTNR1A melatonin receptor 1A 2.0616
ACTL8 actin-like 8 2.04945
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.0494
LCT lactase 2.0489
FOXK2 forkhead box K2 2.0486
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.0447
TRIM21 tripartite motif containing 21 2.04345
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.03915
TUBA3E tubulin, alpha 3e 2.0328
ADGRE3 adhesion G protein-coupled receptor E3 2.0241
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.02345
NGB neuroglobin 2.02065
AKAP3 A kinase (PRKA) anchor protein 3 2.0082
CHSY1 chondroitin sulfate synthase 1 2.006
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.0025

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -7.07258
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -5.60705
MRPS2 mitochondrial ribosomal protein S2 -5.38485
CCNB1 cyclin B1 -5.3039
C2CD5 C2 calcium-dependent domain containing 5 -5.1022
TSPAN4 tetraspanin 4 -4.99095
ZNF586 zinc finger protein 586 -4.91515
NUP85 nucleoporin 85kDa -4.88495
CCNB2 cyclin B2 -4.76175
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.744
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.68332
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.66525
LDHD lactate dehydrogenase D -4.4911
MAP7 microtubule-associated protein 7 -4.32327
USP6NL USP6 N-terminal like -3.96165
CHMP4B charged multivesicular body protein 4B -3.94825
GNAS GNAS complex locus -3.7052
DERA deoxyribose-phosphate aldolase (putative) -3.63595
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.61265
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.3067
MAPK13 mitogen-activated protein kinase 13 -3.20645
ADI1 acireductone dioxygenase 1 -3.1713
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.97705
RGS2 regulator of G-protein signaling 2 -2.97095
SESN1 sestrin 1 -2.90565
CHIC2 cysteine-rich hydrophobic domain 2 -2.7252
IFRD2 interferon-related developmental regulator 2 -2.67692
NRIP1 nuclear receptor interacting protein 1 -2.6644
STAT1 signal transducer and activator of transcription 1, 91kDa -2.61318
HLA-DMA major histocompatibility complex, class II, DM alpha -2.52045
MRPS7 mitochondrial ribosomal protein S7 -2.4527
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -2.3677
PDCD6 programmed cell death 6 -2.22045
SAP30BP SAP30 binding protein -2.21765
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.17615
XPA xeroderma pigmentosum, complementation group A -2.1685
GRIA2 glutamate receptor, ionotropic, AMPA 2 -2.1352
PHF2 PHD finger protein 2 -2.10475
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.09268
SPAG4 sperm associated antigen 4 -2.09245
GTF2IRD1 GTF2I repeat domain containing 1 -2.083
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.0215