CRCGN011_HEPG2_24H:F07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN011_HEPG2_24H:F07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 6.0209
CARMIL1 capping protein regulator and myosin 1 linker 1 5.58285
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.9642
CYCS cytochrome c, somatic 3.6314
MEST mesoderm specific transcript 3.51135
EDN1 endothelin 1 2.9505
BAD BCL2-associated agonist of cell death 2.65805
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.5505
TESK1 testis-specific kinase 1 2.40635
SORBS3 sorbin and SH3 domain containing 3 2.34785
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.19005
PCBP4 poly(rC) binding protein 4 2.0721
HIRIP3 HIRA interacting protein 3 2.0237

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
DNM1L dynamin 1-like -5.33725
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.16265
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9417
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.2437
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.22485
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.8746
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.6962
LAGE3 L antigen family, member 3 -3.6269
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.57497
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.45758
NRIP1 nuclear receptor interacting protein 1 -3.4234
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.38525
HEATR1 HEAT repeat containing 1 -3.02112
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.8805
NPDC1 neural proliferation, differentiation and control, 1 -2.8167
ACAA1 acetyl-CoA acyltransferase 1 -2.70397
OXA1L oxidase (cytochrome c) assembly 1-like -2.6107
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.44945
SLITRK3 SLIT and NTRK-like family, member 3 -2.33555
NANOS3 nanos homolog 3 (Drosophila) -2.26245
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.20912
HLA-DMA major histocompatibility complex, class II, DM alpha -2.1506
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -2.11
ITGB1BP1 integrin beta 1 binding protein 1 -2.10643
TLCD3A TLC domain containing 3A -2.061
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -2.05445
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.01135