CRCGN011_HEPG2_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN011_HEPG2_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 8.82137
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.4854
CIAO3 cytosolic iron-sulfur assembly component 3 5.51405
CXCL2 chemokine (C-X-C motif) ligand 2 5.0621
BLMH bleomycin hydrolase 4.9641
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.6042
E2F2 E2F transcription factor 2 4.5259
MTA2 metastasis associated 1 family, member 2 4.25915
ABHD6 abhydrolase domain containing 6 3.71473
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 3.3473
CHN1 chimerin 1 3.3238
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.31483
SOCS2 suppressor of cytokine signaling 2 3.29243
NUTF2 nuclear transport factor 2 3.14335
SSBP2 single-stranded DNA binding protein 2 3.06135
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.0065
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.99655
GATA3 GATA binding protein 3 2.98613
COL11A1 collagen, type XI, alpha 1 2.98472
OSTF1 osteoclast stimulating factor 1 2.8097
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.79535
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.67188
RBBP5 retinoblastoma binding protein 5 2.63895
PCDH17 protocadherin 17 2.6023
MMP2 matrix metallopeptidase 2 2.55715
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.53075
GUK1 guanylate kinase 1 2.4932
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.4925
WDR76 WD repeat domain 76 2.4853
YOD1 YOD1 deubiquitinase 2.4762
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.4119
PRPF39 pre-mRNA processing factor 39 2.2833
UBA6 ubiquitin-like modifier activating enzyme 6 2.28215
CSF3 colony stimulating factor 3 (granulocyte) 2.2685
MDM4 MDM4, p53 regulator 2.2544
CYCS cytochrome c, somatic 2.2333
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.22675
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.2229
FNDC11 fibronectin type III domain containing 11 2.2058
ACBD3 acyl-CoA binding domain containing 3 2.17225
OVOL1 ovo-like zinc finger 1 2.1626
STRN3 striatin, calmodulin binding protein 3 2.11197
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.11095
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.1038
NKAPD1 NKAP domain containing 1 2.0976
PLSCR3 phospholipid scramblase 3 2.0939
PAQR3 progestin and adipoQ receptor family member III 2.08925
H2BC21 H2B clustered histone 21 2.06245
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.01845

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.82755
CCNB2 cyclin B2 -7.0725
LDHD lactate dehydrogenase D -5.18775
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.0
ADI1 acireductone dioxygenase 1 -4.8201
HAT1 histone acetyltransferase 1 -4.772
FBXL12 F-box and leucine-rich repeat protein 12 -4.65985
ZDHHC6 zinc finger, DHHC-type containing 6 -4.1807
YME1L1 YME1-like 1 ATPase -3.93608
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.8954
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.85795
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.7709
OXA1L oxidase (cytochrome c) assembly 1-like -3.3975
PEG10 paternally expressed 10 -3.32678
NVL nuclear VCP-like -3.2831
PCNA proliferating cell nuclear antigen -3.0837
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.04555
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.9808
GRWD1 glutamate-rich WD repeat containing 1 -2.9644
SNX11 sorting nexin 11 -2.7668
LAPTM4B lysosomal protein transmembrane 4 beta -2.6793
VDAC1 voltage-dependent anion channel 1 -2.67045
PTPRK protein tyrosine phosphatase, receptor type, K -2.56265
TYK2 tyrosine kinase 2 -2.52875
INPP1 inositol polyphosphate-1-phosphatase -2.42175
NRIP1 nuclear receptor interacting protein 1 -2.40523
ASXL2 additional sex combs like transcriptional regulator 2 -2.35075
TTC27 tetratricopeptide repeat domain 27 -2.31285
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.24625
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.21465
DNMBP dynamin binding protein -2.20335
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.1604
C2CD2 C2 calcium-dependent domain containing 2 -2.0971
BIN2 bridging integrator 2 -2.04145