CRCGN011_HEPG2_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

190 genes differentially expressed following the CRCGN011_HEPG2_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.51725
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.4357
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.41015
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.24465
AMDHD2 amidohydrolase domain containing 2 5.0
ANO1 anoctamin 1, calcium activated chloride channel 5.0
TLR4 toll-like receptor 4 4.9919
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9804
E2F2 E2F transcription factor 2 4.97705
KLHL21 kelch-like family member 21 4.9341
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.86265
CCDC92 coiled-coil domain containing 92 4.8504
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.8315
UBQLN2 ubiquilin 2 4.6993
RPP38 ribonuclease P/MRP 38kDa subunit 4.6927
MCOLN1 mucolipin 1 4.62715
PPARG peroxisome proliferator-activated receptor gamma 4.38695
CYCS cytochrome c, somatic 4.07665
MAP7 microtubule-associated protein 7 4.06048
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 3.8289
CHN1 chimerin 1 3.38655
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.8576
CXXC4 CXXC finger protein 4 2.82145
CEP57 centrosomal protein 57kDa 2.79592
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.78305
RNF31 ring finger protein 31 2.6679
H2BC17 H2B clustered histone 17 2.66745
GPER1 G protein-coupled estrogen receptor 1 2.66062
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.5579
GPATCH8 G patch domain containing 8 2.5415
PCDHB11 protocadherin beta 11 2.5399
NRTN neurturin 2.53135
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.51835
CAPN1 calpain 1, (mu/I) large subunit 2.5122
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.49905
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.49575
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.4815
F8A2 coagulation factor VIII-associated 2 2.4795
ICA1 islet cell autoantigen 1, 69kDa 2.47625
BSN bassoon presynaptic cytomatrix protein 2.46195
SLC30A10 solute carrier family 30, member 10 2.45
MGST3 microsomal glutathione S-transferase 3 2.42275
SLC17A4 solute carrier family 17, member 4 2.39985
RIPOR1 RHO family interacting cell polarization regulator 1 2.3989
MMP27 matrix metallopeptidase 27 2.3974
FAM163A family with sequence similarity 163, member A 2.38053
PKLR pyruvate kinase, liver and RBC 2.37525
CCR3 chemokine (C-C motif) receptor 3 2.375
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.37392
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.3689
CAPNS1 calpain, small subunit 1 2.363
TEX10 testis expressed 10 2.3545
NYX nyctalopin 2.35045
ONECUT2 one cut homeobox 2 2.3369
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.3095
GRIK3 glutamate receptor, ionotropic, kainate 3 2.30385
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.3025
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.2965
TET3 tet methylcytosine dioxygenase 3 2.2963
SIRT4 sirtuin 4 2.27755
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.2773
WDR7 WD repeat domain 7 2.2722
LGALS13 lectin, galactoside-binding, soluble, 13 2.26885
C18ORF25 chromosome 18 open reading frame 25 2.26323
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.2468
CPNE2 copine II 2.23415
KLHL36 kelch-like family member 36 2.23315
FOXL1 forkhead box L1 2.20705
CPTP ceramide-1-phosphate transfer protein 2.20365
KIAA0040 KIAA0040 2.19773
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 2.19735
HPS6 Hermansky-Pudlak syndrome 6 2.186
SCN4A sodium channel, voltage gated, type IV alpha subunit 2.1857
DLX2 distal-less homeobox 2 2.1836
CCKAR cholecystokinin A receptor 2.1782
SCN3B sodium channel, voltage gated, type III beta subunit 2.17578
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.17475
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.17285
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.16975
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.1682
NRG2 neuregulin 2 2.1614
HMBOX1 homeobox containing 1 2.1582
OPRM1 opioid receptor, mu 1 2.15713
MCM3 minichromosome maintenance complex component 3 2.1562
GML glycosylphosphatidylinositol anchored molecule like 2.1525
SMAD4 SMAD family member 4 2.15055
CFAP46 cilia and flagella associated protein 46 2.14405
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.1403
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.13955
RUNX2 runt-related transcription factor 2 2.13552
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.13415
CPLX2 complexin 2 2.1297
CDH9 cadherin 9, type 2 (T1-cadherin) 2.1296
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.12755
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.1243
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.12245
CLEC1A C-type lectin domain family 1, member A 2.11975
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.1107
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.1098
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 2.10553
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.09635
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.09593
OTOR otoraplin 2.09445
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.09035
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.0869
CALCR calcitonin receptor 2.08492
FAM124B family with sequence similarity 124B 2.0809
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.0808
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.08065
WNT10B wingless-type MMTV integration site family, member 10B 2.08
GPR32 G protein-coupled receptor 32 2.07605
LIPE lipase, hormone-sensitive 2.07413
OR2B2 olfactory receptor, family 2, subfamily B, member 2 2.0671
INPPL1 inositol polyphosphate phosphatase-like 1 2.06635
CHD6 chromodomain helicase DNA binding protein 6 2.06287
CAMKMT calmodulin-lysine N-methyltransferase 2.06235
ZNF33B zinc finger protein 33B 2.0545
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.05345
HRAS Harvey rat sarcoma viral oncogene homolog 2.0512
FPR3 formyl peptide receptor 3 2.0495
WNT1 wingless-type MMTV integration site family, member 1 2.04775
CRYBB1 crystallin, beta B1 2.04505
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.04315
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.04135
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.03755
LAMB4 laminin, beta 4 2.03405
ZNF821 zinc finger protein 821 2.03285
IL4 interleukin 4 2.03095
DEDD death effector domain containing 2.02705
CABP5 calcium binding protein 5 2.0261
CRYBA4 crystallin, beta A4 2.02545
SPRYD7 SPRY domain containing 7 2.0248
GOLT1A golgi transport 1A 2.0241
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 2.02128
KRT12 keratin 12, type I 2.01615
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.01335
BMP10 bone morphogenetic protein 10 2.012
KNL1 kinetochore scaffold 1 2.0106
WNT8B wingless-type MMTV integration site family, member 8B 2.01045
GIPC2 GIPC PDZ domain containing family, member 2 2.00985
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.007
SIGLEC15 sialic acid binding Ig-like lectin 15 2.00275
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 2.0027
CBX2 chromobox homolog 2 2.0023
PEX5L peroxisomal biogenesis factor 5-like 2.00115
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.0005
MAGEA1 melanoma antigen family A1 2.00025

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.4523
CCNB2 cyclin B2 -7.1852
YME1L1 YME1-like 1 ATPase -6.37528
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.70425
KDM3A lysine (K)-specific demethylase 3A -5.2508
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.109
GDF15 growth differentiation factor 15 -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.92685
CD320 CD320 molecule -4.7915
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.69595
CDC20 cell division cycle 20 -4.66275
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.50635
FBXL12 F-box and leucine-rich repeat protein 12 -4.4348
NCK1 NCK adaptor protein 1 -4.3271
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.23855
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.06015
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.86245
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.44595
ADI1 acireductone dioxygenase 1 -3.30165
STAMBP STAM binding protein -3.08645
RFC2 replication factor C (activator 1) 2, 40kDa -2.84993
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.81555
RGS2 regulator of G-protein signaling 2 -2.6754
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.58675
HEATR1 HEAT repeat containing 1 -2.4445
WASHC4 WASH complex subunit 4 -2.35863
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3201
PROS1 protein S (alpha) -2.3022
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27837
CCND2 cyclin D2 -2.2746
MAP2K1 mitogen-activated protein kinase kinase 1 -2.20615
NSG1 neuron specific gene family member 1 -2.19948
IL10RB interleukin 10 receptor, beta -2.15745
LGMN legumain -2.12045
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.11275
GPR137B G protein-coupled receptor 137B -2.0943
MSL2 male-specific lethal 2 homolog (Drosophila) -2.0898
SEC61G Sec61 gamma subunit -2.089
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.0888
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.0853
RAB8A RAB8A, member RAS oncogene family -2.08215
SMIM7 small integral membrane protein 7 -2.06545
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.0569