CRCGN011_HEPG2_24H:F11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN011_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.81165
JADE2 jade family PHD finger 2 5.45073
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 5.1415
CARMIL1 capping protein regulator and myosin 1 linker 1 4.93775
TLR4 toll-like receptor 4 4.79945
MYLK myosin light chain kinase 4.6395
SNAP25 synaptosomal-associated protein, 25kDa 4.09648
MAP7 microtubule-associated protein 7 3.99943
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.96391
STAP2 signal transducing adaptor family member 2 3.94665
ABHD6 abhydrolase domain containing 6 3.86458
DYNLT3 dynein, light chain, Tctex-type 3 3.6045
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.26578
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.26265
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 3.04045
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.85255
RBL1 retinoblastoma-like 1 2.78585
MOK MOK protein kinase 2.6715
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.59985
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.5809
ARID4B AT rich interactive domain 4B (RBP1-like) 2.5259
INO80D INO80 complex subunit D 2.47545
ADGRD2 adhesion G protein-coupled receptor D2 2.464
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.4393
CCDC82 coiled-coil domain containing 82 2.42615
OBI1 ORC ubiquitin ligase 1 2.4226
CPLX2 complexin 2 2.41445
FNDC8 fibronectin type III domain containing 8 2.4058
KIF18A kinesin family member 18A 2.3886
FANCC Fanconi anemia, complementation group C 2.38645
TPD52L2 tumor protein D52-like 2 2.37125
STAB2 stabilin 2 2.36355
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.3572
EMC2 ER membrane protein complex subunit 2 2.34275
CYCS cytochrome c, somatic 2.33345
RNF167 ring finger protein 167 2.3014
CPED1 cadherin-like and PC-esterase domain containing 1 2.2974
SHCBP1 SHC SH2-domain binding protein 1 2.2896
PUF60 poly-U binding splicing factor 60KDa 2.28895
DAO D-amino-acid oxidase 2.2832
NEU2 sialidase 2 (cytosolic sialidase) 2.2788
GJB1 gap junction protein, beta 1, 32kDa 2.2769
CENPO centromere protein O 2.2693
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.2627
MYOG myogenin (myogenic factor 4) 2.2568
RGS7 regulator of G-protein signaling 7 2.25095
CDC45 cell division cycle 45 2.2328
AGMAT agmatine ureohydrolase (agmatinase) 2.2282
COMMD3-BMI1 COMMD3-BMI1 readthrough 2.2278
RPL10L ribosomal protein L10-like 2.21745
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.21143
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.20305
ZBP1 Z-DNA binding protein 1 2.2005
GRAMD1B GRAM domain containing 1B 2.1892
TPCN1 two pore segment channel 1 2.188
CCNE2 cyclin E2 2.18645
UFM1 ubiquitin-fold modifier 1 2.1792
PAOX polyamine oxidase (exo-N4-amino) 2.17898
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.17025
RPAIN RPA interacting protein 2.16915
CIDEB cell death-inducing DFFA-like effector b 2.16325
WDTC1 WD and tetratricopeptide repeats 1 2.15035
CRYBB3 crystallin, beta B3 2.14185
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.14
BORCS8 BLOC-1 related complex subunit 8 2.1387
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.13775
DCHS2 dachsous cadherin-related 2 2.13715
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.13605
SSTR3 somatostatin receptor 3 2.1335
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.1304
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.12535
NECAP2 NECAP endocytosis associated 2 2.10855
SPC25 SPC25, NDC80 kinetochore complex component 2.09985
HDAC11 histone deacetylase 11 2.09055
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.0891
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.08025
TMCC2 transmembrane and coiled-coil domain family 2 2.0672
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.065
ARSJ arylsulfatase family, member J 2.0611
SLC12A9 solute carrier family 12, member 9 2.0588
FAM204A family with sequence similarity 204, member A 2.0574
MED31 mediator complex subunit 31 2.0538
DNA2 DNA replication helicase/nuclease 2 2.05275
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.0483
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.0466
TMEM209 transmembrane protein 209 2.04555
PCDHA10 protocadherin alpha 10 2.0447
POC1B-GALNT4 POC1B-GALNT4 readthrough 2.0426
ZNF747 zinc finger protein 747 2.03885
KIAA1614 KIAA1614 2.03355
GPR31 G protein-coupled receptor 31 2.02705
GAA glucosidase, alpha; acid 2.0232
CENPQ centromere protein Q 2.01975
IL17B interleukin 17B 2.0159
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.01417
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.01315
S100A3 S100 calcium binding protein A3 2.01255
KRT6B keratin 6B, type II 2.0

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.0254
GNAS GNAS complex locus -7.29517
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.42475
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.3224
NT5DC2 5'-nucleotidase domain containing 2 -5.29885
ISOC1 isochorismatase domain containing 1 -4.94475
GDF15 growth differentiation factor 15 -4.8093
LDHD lactate dehydrogenase D -4.73895
CCDC86 coiled-coil domain containing 86 -4.66275
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.6169
TUBB6 tubulin, beta 6 class V -4.53625
CCNB2 cyclin B2 -4.52615
COG2 component of oligomeric golgi complex 2 -4.22915
CDC20 cell division cycle 20 -4.2155
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.9215
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.49115
NGRN neugrin, neurite outgrowth associated -3.44525
VDAC1 voltage-dependent anion channel 1 -2.89565
NVL nuclear VCP-like -2.6513
MAPK13 mitogen-activated protein kinase 13 -2.63103
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.46452
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.3587
CNPY3-GNMT CNPY3-GNMT readthrough -2.29785
PRCC papillary renal cell carcinoma (translocation-associated) -2.2622
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2573
RLN1 relaxin 1 -2.2225
BOLA2B bolA family member 2B -2.1827
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.1585
TRIM52 tripartite motif containing 52 -2.0759
ZNF586 zinc finger protein 586 -2.0637
CSNK1E casein kinase 1, epsilon -2.05397
PAK1IP1 PAK1 interacting protein 1 -2.03575
IPO13 importin 13 -2.0251