| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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73 genes differentially expressed following the CRCGN011_HEPG2_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| JADE2 | jade family PHD finger 2 | 5.29163 |
| E2F2 | E2F transcription factor 2 | 5.02295 |
| STIMATE | STIM activating enhancer | 4.73055 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.7297 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 4.62358 |
| STK10 | serine/threonine kinase 10 | 4.14943 |
| CHN1 | chimerin 1 | 4.0198 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.79432 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.4918 |
| LCN2 | lipocalin 2 | 3.4406 |
| PRKCH | protein kinase C, eta | 3.39582 |
| ATP11B | ATPase, class VI, type 11B | 3.19965 |
| CCNF | cyclin F | 3.09845 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 3.05985 |
| CREB1 | cAMP responsive element binding protein 1 | 2.96653 |
| GPATCH8 | G patch domain containing 8 | 2.81437 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.7914 |
| FZD7 | frizzled class receptor 7 | 2.729 |
| RNF167 | ring finger protein 167 | 2.59455 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.52135 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 2.49855 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 2.40205 |
| VPS39 | vacuolar protein sorting 39 homolog (S. cerevisiae) | 2.3903 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 2.3844 |
| SETD5 | SET domain containing 5 | 2.32255 |
| CDK3 | cyclin-dependent kinase 3 | 2.23675 |
| TACO1 | translational activator of mitochondrially encoded cytochrome c oxidase I | 2.2223 |
| ZNF282 | zinc finger protein 282 | 2.18255 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 2.12325 |
| TCF21 | transcription factor 21 | 2.1222 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | 2.09545 |
| EDN1 | endothelin 1 | 2.0823 |
| LYRM2 | LYR motif containing 2 | 2.06145 |
| UBQLN2 | ubiquilin 2 | 2.0588 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2.05693 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.02545 |
| GJB1 | gap junction protein, beta 1, 32kDa | 2.0221 |
| GAMT | guanidinoacetate N-methyltransferase | 2.01525 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -10.0 |
| PCNA | proliferating cell nuclear antigen | -8.24415 |
| KDM3A | lysine (K)-specific demethylase 3A | -5.1275 |
| LAP3 | leucine aminopeptidase 3 | -5.0687 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -4.8632 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.8081 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.7862 |
| CDC20 | cell division cycle 20 | -4.66275 |
| THAP11 | THAP domain containing 11 | -4.5957 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.45695 |
| TUBB6 | tubulin, beta 6 class V | -4.43745 |
| CCDC86 | coiled-coil domain containing 86 | -4.3902 |
| TLCD3A | TLC domain containing 3A | -4.3494 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -4.19855 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -3.48105 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.4473 |
| WASHC4 | WASH complex subunit 4 | -3.36747 |
| USP6NL | USP6 N-terminal like | -3.29375 |
| GNAS | GNAS complex locus | -3.01866 |
| ADI1 | acireductone dioxygenase 1 | -2.89735 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.87175 |
| PRPF4 | pre-mRNA processing factor 4 | -2.8141 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.804 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.60258 |
| FBXO7 | F-box protein 7 | -2.47615 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.2496 |
| NRIP3 | nuclear receptor interacting protein 3 | -2.199 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -2.1881 |
| LRRC40 | leucine rich repeat containing 40 | -2.1572 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.1164 |
| TOR4A | torsin family 4, member A | -2.107 |
| PRPF19 | pre-mRNA processing factor 19 | -2.07995 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -2.059 |
| CPNE3 | copine III | -2.03367 |
| MKKS | McKusick-Kaufman syndrome | -2.0044 |
